Electrospun poly(ethylene oxide)/chitosan nanofibers with cellulose nanocrystals as support for cell culture of 3T3 fibroblasts

Ridolfi, Daniela Missiani; Lemes, Ana Paula; Oliveira, Sheila de; Justo, Giselle Z.; Palladino, Marcelly V.; Durán, Nélson

doi:10.1007/s10570-017-1362-2

Cited by 37 publications

(38 citation statements)

References 56 publications

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“…Figure 6b shows the thermogravimetric analyses of CCS/PEO composite nanofiber scaffolds. As previously reported [57,59], a low weight loss occurred at 80–100 °C due to the moisture present in those nanofiber scaffolds, and the higher weight loss of 4:1 CCS/PEO nanofiber scaffold than the others might be because there was more water in the scaffold. At the range of 100–200 °C, the scaffolds were stable and no weight loss.…”

Section: Resultssupporting

confidence: 64%

“…Figure 6c shows that there are two degradation rate peaks for each sample at 270 °C and 400 °C, respectively. It illustrated that the maximum degradation rate of those CCS/PEO composite nanofibers occurred by compounding of PEO and CCS [59]. Therefore, these nanofiber scaffolds were thermally stable.…”

Section: Resultsmentioning

confidence: 99%

“…The peak of 962 cm −1 was due to the vibration of ether group [60]. The triplet peaks of 1060, 1099 and 1145 cm −1 were attributed to the C–O–C stretching vibrations [57,59]. The peaks of 1342, 1560 and 1649 cm −1 were attributed to amide III, amide I and amide II, respectively [13,61].…”

Section: Resultsmentioning

confidence: 99%

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High Efficiency Fabrication of Chitosan Composite Nanofibers with Uniform Morphology via Centrifugal Spinning

Shunqi

Dong

et al. 2019

Polymers

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While electrospinning has been widely employed to spin nanofibers, its low production rate has limited its potential for industrial applications. Comparing with electrospinning, centrifugal spinning technology is a prospective method to fabricate nanofibers with high productivity. In the current study, key parameters of the centrifugal spinning system, including concentration, rotational speed, nozzle diameter and nozzle length, were studied to control fiber diameter. An empirical model was established to determine the final diameters of nanofibers via controlling various parameters of the centrifugal spinning process. The empirical model was validated via fabrication of carboxylated chitosan (CCS) and polyethylene oxide (PEO) composite nanofibers. DSC and TGA illustrated that the thermal properties of CCS/PEO nanofibers were stable, while FTIR-ATR indicated that the chemical structures of CCS and PEO were unchanged during composite fabrication. The empirical model could provide an insight into the fabrication of nanofibers with desired uniform diameters as potential biomedical materials. This study demonstrated that centrifugal spinning could be an alternative method for the fabrication of uniform nanofibers with high yield.

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Section: Resultssupporting

confidence: 64%

Section: Resultsmentioning

confidence: 99%

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High Efficiency Fabrication of Chitosan Composite Nanofibers with Uniform Morphology via Centrifugal Spinning

Shunqi

Dong

et al. 2019

Polymers

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“…They are needle-shaped nanostructures used in composites as reinforcement to improve essential properties in materials such as thermal stability, water and mechanical resistance [18][19][20][21][22] . They can be used for drug delivery, protein and enzyme immobilization, support cell cultures, biosensing and bioethanol production 17,[23][24][25] .…”

Section: Introductionmentioning

confidence: 99%

Study of Cellulose Nanocrystals and Zinc Nitrate Hexahydrate Addition in Chitosan Hydrogels

et al. 2019

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In this study, chitosan hydrogels were produced with 0, 2, 4 and 6 wt% of cellulose nanocrystals (CNC) using hexahydrate zinc nitrate (Zn(NO 3) 2 .6H 2 O) as a catalyst for chitosan crosslinking reaction. CNC´s size was estimated by dynamic light scattering (DLS) and surface charge by zeta potential. Hydrogels were characterized by rotational rheometer, swelling test, uniaxial compression test, in vitro degradation, scanning electron microscopy (SEM) and microtomography. Results showed that zinc nitrate and CNC addition did not influence mechanical properties, degradation, and morphology of the hydrogels. However, zinc nitrate decreased 36.54% of the gel time and 41.37% of the swelling degree, and increased the crosslinking degree of the chitosan hydrogels, proving not only its catalytic effect but also its participation in the crosslinking reaction. Porosity was slightly reduced after addition of zinc nitrate and incorporation of CNC. In the mechanism of crosslinking reaction, a competition between CNC and zinc nitrate was observed.

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“…Among such materials that are readily available, CNC have attracted great interest owing to its renewability, biodegradability, and spectacular mechanical properties [24,25]. Incorporating CNC into electrospinning of different polymers can improve the mechanical and thermal properties of nanofibers [26]. Xu introduced CNC into the CS/PVA matrix to improve its insufficient mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Cellulose Nanocrystals/Chitosan/Polyvinyl Alcohol Nanofibrous Films and their Exploration to Metal Ions Adsorption

et al. 2018

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Cellulose nanocrystals/chitosan/polyvinyl alcohol (CNC/CS/PVA) composite nanofibrous films were prepared while using an electrospinning technique and successfully thiol-functionalized. Then, the modified films were used for the sorption-desorption of Cu(II) and Pb(II) ions. Subsequently, the adsorption capacity of the films was investigated by changing the CNC loading level, solution pH, and adsorption time. Results showed that the adsorption of metal ions by the films was the best with CNC loading level of 5 wt %, pH of 6, and adsorption time of 4 h. The adsorption behavior of the films was agreed with the Freundlich model. The adsorption equation of metal ions could be described while using a pseudo-second order model. Based on the Langmuir model, the maximum adsorption capacities of Cu(II) and Pb(II) ions were estimated to be 484.06 and 323.49 mg/g, respectively. The Cu(II) and Pb(II) ions adsorption efficiencies of the films after 4 adsorption-desorption cycles were 90.58% and 90.21%, respectively. This study may provide a feasible approach for the application of functional CNC/CS/PVA nanofibrous films in the treatment of water.

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Electrospun poly(ethylene oxide)/chitosan nanofibers with cellulose nanocrystals as support for cell culture of 3T3 fibroblasts

Cited by 37 publications

References 56 publications

High Efficiency Fabrication of Chitosan Composite Nanofibers with Uniform Morphology via Centrifugal Spinning

High Efficiency Fabrication of Chitosan Composite Nanofibers with Uniform Morphology via Centrifugal Spinning

Study of Cellulose Nanocrystals and Zinc Nitrate Hexahydrate Addition in Chitosan Hydrogels

Electrospun Cellulose Nanocrystals/Chitosan/Polyvinyl Alcohol Nanofibrous Films and their Exploration to Metal Ions Adsorption

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