Electrospun poly lactic acid (PLA) fibres: Effect of different solvent systems on fibre morphology and diameter

A Non-woven Path: Electrospun Poly(lactic acid) Scaffolds for Kidney Tissue Engineering

“…The increase in porosity of 97.3% gained from cryogenic electrospinning, demonstrated in the dramatic increase in thickness of the scaffold spun under the same conditions as large fibres, comes at the cost of mechanical strength; fibres had an UTS 5 times lower despite spinning under the same parameters, this follows a similar trend to previous works [37,51]. The variation seen in scaffold thickness may be influenced by a decrease in humidity due to the low temperature as humidity is known to effect the diameter of electrospun fibres [52], the low temperature of the mandrel may also reduce the ambient temperature increasing the viscosity of the polymer solution [53]. Interestingly, Young's modulus peaks in normally spun scaffolds at 2-3% strain but at 3-4% for cryogenically spun fibres this is probably due the nature of the scaffold and looser packing in cryogenic fibres allowing for more strain in the scaffold before all fibres are in tension.…”

Scaled-up preparation of drug-loaded electrospun polymer fibres and investigation of their continuous processing to tablet form

“…With IPA, a solvent with relatively large viscosity (2.86 cP at 15°C), slightly thicker PVPVA64-based fibres with some beads could be obtained (Figure 3a). An increase in viscosity usually leads to thicker fibres [54,55]. However, it can occur that fibres with larger diameter release the encapsulated drug faster than nanofibres due to the easier accessibility [56].…”

Plasma surface functionalization of biodegradable electrospun scaffolds for tissue engineering applications

“…Particularly, in the past decade electrospun PLLA scaffolds are being increasingly utilized. This is partially due to the fact that PLLA is soluble in the majority of organic solvents such as chlorinated solvents, tetrahydrofuran (THF), dioxane and acetonitrile; and by choosing appropriate solvent systems, a very good quality of PLLA fibers can be obtained [51,52].…”