Electrospun poly(styrene-co-maleic anhydride) nanofibrous membrane: A versatile platform for mixed mode membrane adsorbers

Ye, Jianlong; Wang, Xushan; Chu, Jiachen; Yao, Dongxue; Zhang, Yufeng; Meng, Jianqiang

doi:10.1016/j.apsusc.2019.04.106

Cited by 21 publications

(2 citation statements)

References 40 publications

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“…So far, the versatility of electrospun membrane adsorbers has been studied primarily in terms of design, fabrication, and type of functionalization [ 19 ]. However, many of these adsorbers require multistep synthesis for functionalization [ 26 , 27 , 28 , 29 , 30 , 31 , 32 ], which limits their entrance into industry and the market. To overcome this, alternative fabrication routes, such as the use of pre-functionalized polymers should be explored [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

On the Performance of a Ready-to-Use Electrospun Sulfonated Poly(Ether Ether Ketone) Membrane Adsorber

Joosten,

Wyrębak,

Schenning

et al. 2023

Membranes

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Motivated by the need for efficient purification methods for the recovery of valuable resources, we developed a wire-electrospun membrane adsorber without the need for post-modification. The relationship between the fiber structure, functional-group density, and performance of electrospun sulfonated poly(ether ether ketone) (sPEEK) membrane adsorbers was explored. The sulfonate groups enable selective binding of lysozyme at neutral pH through electrostatic interactions. Our results show a dynamic lysozyme adsorption capacity of 59.3 mg/g at 10% breakthrough, which is independent of the flow velocity confirming dominant convective mass transport. Membrane adsorbers with three different fiber diameters (measured by SEM) were fabricated by altering the concentration of the polymer solution. The specific surface area as measured with BET and the dynamic adsorption capacity were minimally affected by variations in fiber diameter, offering membrane adsorbers with consistent performance. To study the effect of functional-group density, membrane adsorbers from sPEEK with different sulfonation degrees (52%, 62%, and 72%) were fabricated. Despite the increased functional-group density, the dynamic adsorption capacity did not increase accordingly. However, in all presented cases, at least a monolayer coverage was obtained, demonstrating ample functional groups available within the area occupied by a lysozyme molecule. Our study showcases a ready-to-use membrane adsorber for the recovery of positively charged molecules, using lysozyme as a model protein, with potential applications in removing heavy metals, dyes, and pharmaceutical components from process streams. Furthermore, this study highlights factors, such as fiber diameter and functional-group density, for optimizing the membrane adsorber’s performance.

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Section: Introductionmentioning

confidence: 99%

On the Performance of a Ready-to-Use Electrospun Sulfonated Poly(Ether Ether Ketone) Membrane Adsorber

Joosten,

Wyrębak,

Schenning

et al. 2023

Membranes

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“…Traditional column chromatography has high adsorption capacity and separation accuracy for protein [ 1 , 2 ]; so far, the downstream processing of biological agents has been highly dependent on the use of packed bed resin columns [ 3 , 4 ]. However, traditional column chromatography generally suffers from a high-pressure drop; the intraparticle diffusion leads to the accumulation of solute molecules, which made the processing time increases, low ligand utilization, and long treatment time, which limits its productivity [ 5 , 6 ]; meanwhile, column chromatography is expensive; more than 60% of the cost of the biopharmaceutical production process is concentrated in the downstream process of purification and recovery, in which the downstream purification of virus accounts for 70% of the total production cost [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Recent development and application of membrane chromatography

Chen

Cong

et al. 2022

Anal Bioanal Chem

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Membrane chromatography is mainly used for the separation and purification of proteins and biological macromolecules in the downstream processing process, also applications in sewage disposal. Membrane chromatography is recognized as an effective alternative to column chromatography because it significantly improves chromatography from affinity, hydrophobicity, and ion exchange; the development status of membrane chromatography in membrane matrix and membrane equipment is thoroughly discussed, and the applications of protein capture and intermediate purification, virus, monoclonal antibody purification, water treatment, and others are summarized. This review will provide value for the exploration and potential application of membrane chromatography. Graphical abstract

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Nanocomposites by in situ polymerization based on styrene-maleic anhydride copolymer and clay

et al. 2022

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Electrospun poly(styrene-co-maleic anhydride) nanofibrous membrane: A versatile platform for mixed mode membrane adsorbers

Cited by 21 publications

References 40 publications

On the Performance of a Ready-to-Use Electrospun Sulfonated Poly(Ether Ether Ketone) Membrane Adsorber

On the Performance of a Ready-to-Use Electrospun Sulfonated Poly(Ether Ether Ketone) Membrane Adsorber

Recent development and application of membrane chromatography

Nanocomposites by in situ polymerization based on styrene-maleic anhydride copolymer and clay

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