Electrospun polyamide-6/chitosan nanofibers reinforced nano-hydroxyapatite/polyamide-6 composite bilayered membranes for guided bone regeneration

Niu, Xiaolian; Wang, Long-Fei; Xu, Mengjie; Miao, Qiguang; Zhao, Liqin; Wei, Yan; Hu, Yinchun; Lian, Xiaojie; Liang, Ziwei; Song, Chen; Chen, Weiyi; Huang, Di

doi:10.1016/j.carbpol.2021.117769

Cited by 72 publications

(39 citation statements)

References 59 publications

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“…Extensive research has been conducted to develop guided bone and tissue regeneration membranes based on chitosan nanofibers for periodontal regeneration [ 216 , 217 , 218 , 219 , 220 , 221 , 222 ]. Jin et al (2018) prepared electrospun nanofibers of chitosan blended with silver-ion-loaded calcium phosphate, and crosslinked them with vanillin.…”

Section: Marine Animal-derived Biopolymersmentioning

confidence: 99%

“…The scaffolds demonstrated improved mechanical properties due to strong molecular interactions and chemical bonding between the components of the nanofibers and the cast film. Furthermore, the bilayer scaffolds exhibited sufficient biocompatibility and osteoconductivity, suggesting their potential for bone regeneration applications ( Figure 8 C) [ 221 ].…”

Section: Marine Animal-derived Biopolymersmentioning

confidence: 99%

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Marine Biopolymers as Bioactive Functional Ingredients of Electrospun Nanofibrous Scaffolds for Biomedical Applications

et al. 2022

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Marine biopolymers, abundantly present in seaweeds and marine animals, feature diverse structures and functionalities, and possess a wide range of beneficial biological activities. Characterized by high biocompatibility and biodegradability, as well as unique physicochemical properties, marine biopolymers are attracting a constantly increasing interest for the development of advanced systems for applications in the biomedical field. The development of electrospinning offers an innovative technological platform for the production of nonwoven nanofibrous scaffolds with increased surface area, high encapsulation efficacy, intrinsic interconnectivity, and structural analogy to the natural extracellular matrix. Marine biopolymer-based electrospun nanofibrous scaffolds with multifunctional characteristics and tunable mechanical properties now attract significant attention for biomedical applications, such as tissue engineering, drug delivery, and wound healing. The present review, covering the literature up to the end of 2021, highlights the advancements in the development of marine biopolymer-based electrospun nanofibers for their utilization as cell proliferation scaffolds, bioadhesives, release modifiers, and wound dressings.

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Section: Marine Animal-derived Biopolymersmentioning

confidence: 99%

Section: Marine Animal-derived Biopolymersmentioning

confidence: 99%

Marine Biopolymers as Bioactive Functional Ingredients of Electrospun Nanofibrous Scaffolds for Biomedical Applications

et al. 2022

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“…(C) Schematic diagram showing the preparation of bilayered guided membranes with polyamide-6/chitosan nanofiber as the top layer while the n-HA/polyamide-6 film as the bottom layer. Reproduced with permission ( Niu et al, 2021 ). Copyright 2021, Elsevier.…”

Section: Engineering Nanofibers With Specific-controlled Structuresmentioning

confidence: 99%

“…Osteogenic differentiation was also significantly enhanced in rat critical defects model. In another study, bilayered guided membranes with polyamide-6/chitosan fibers as the top layer while the n-HA/polyamide-6 film as the bottom layer were fabricated for guided bone regeneration ( Figure 4C ) ( Niu et al, 2021 ). This two-step approach mainly involved the use of electrospinning technique for preparing the top layer and solvent casting for producing the bottom layer.…”

Section: Engineering Nanofibers With Specific-controlled Structuresmentioning

confidence: 99%

Engineering Electrospun Nanofibers for the Treatment of Oral Diseases

Wang¹,

Liu²,

Zhang³

et al. 2021

Front. Chem.

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With the increase of consumption of high-sugar foods, beverages, tobacco, and alcohol, the incidence rate of oral diseases has been increasing year by year. Statistics showed that the prevalence of oral diseases such as dental caries, dental pulpal disease, and periodontal disease has reached as high as 97% in 2015 in China. It is thus urgent to develop functional materials or products for the treatment of oral diseases. Electrospinning has been a widely used technology that is capable of utilizing polymer solution to generate micro/nano fibers under an appropriate high voltage condition. Owing to their excellent structures and biological performances, materials prepared by electrospinning technology have been used for a wide range of oral-related applications, such as tissue restoration, controlled drug release, anti-cancer, etc. In this regard, this article reviews the application and progress of electrospun nanofibers to various oral diseases in recent years. Firstly, engineering strategies of a variety of nanofiber structures together with their resultant functions will be introduced. Then, biological functions of electrospun nanofibers as well as their applications in the treatment of oral diseases are summarized and demonstrated. Finally, the development viewpoint of functional nanofibers is prospected, which is expected to lay the foundation and propose the direction for further clinical application.

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“…Guided bone regeneration (GBR) membrane is commonly used to augment defect area, where Tel. : +86 0731 8887 3111; fax: +86 0731 8887 3111, E-mail address: jlytxg@163.com, tangxg@hunnu.edu.cn, huxiangsky123123@163.com the membrane was placed on the bone defect area as barrier membrane to create a singular space, so as to prevent epithelial cells from growing into the defect, and permit the proliferation of osteoblasts and new bone formation for bone tissue regeneration (Jiang et al, 2015;Niu et al, 2021;Li et al, 2020;. Ideally, GBR membrane should possess appropriate mechanical properties, space-retention ability, biocompatibility and biodegradability (Lee et al, 2016;Yu et al, 2020;Hoornaert et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Effect of Different Preparation Conditions On The Properties of Bamboo Fiber-Based Bioactive Composite Membrane

Liuyun

Jiang

et al. 2022

Preprint

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A novel nano-hydroxyapatite/bamboo fiber (n-HA/BF) bioactive composite membrane was obtained by a simple casting technique. The membrane forming mechanism and the effects of different forming membrane methods, drying methods and n-HA amounts on the properties of n-HA/BF membrane were investigated by Fourier Transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), contact angle, electromechanical universal tester, in vitro soaking in simulated body fluid (SBF) and in vitro cell cultureexperiment. The results demonstrated that the n-HA dispersity in BF matix was not affected by the prepartion condition, however, the morphologies of membrane was determined by the different preparation conditions owing to different hydrogen bond shrinkage. Moreover, the hydrophilicity of the composite membrane was improved under the condition of the membrane formation in oven, freeze drying and high addition content of n-HA, and the mechanical properties of composite membrane depended on n-HA content. In vitro soaking behavior indicated that the degradability and bone-like apatite deposition could be controled by differentpreparation conditions. And the cell proliferation experiment showed that the n-HA/BF composite membranes obtained under different preparation conditions were all non-toxic. The above results indicated that the n-HA/BF composite membrane could be obtained by a simple casting technique, and the properties could be controlled by adopting different preparation conditions, which would have a great promising as guide bone tissue regeneration (GBR) membrane, and the study would provide a new application for BF in biomedical field.

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Electrospun polyamide-6/chitosan nanofibers reinforced nano-hydroxyapatite/polyamide-6 composite bilayered membranes for guided bone regeneration

Cited by 72 publications

References 59 publications

Marine Biopolymers as Bioactive Functional Ingredients of Electrospun Nanofibrous Scaffolds for Biomedical Applications

Marine Biopolymers as Bioactive Functional Ingredients of Electrospun Nanofibrous Scaffolds for Biomedical Applications

Engineering Electrospun Nanofibers for the Treatment of Oral Diseases

Effect of Different Preparation Conditions On The Properties of Bamboo Fiber-Based Bioactive Composite Membrane

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