Electrospun polycaprolactone/gelatin composites with enhanced cell–matrix interactions as blood vessel endothelial layer scaffolds

Creation of a unique architectural structure of bioactive glass sub‐micron particles incorporated in a polycaprolactone/gelatin fibrous mat; characterization, bioactivity, and cellular evaluations

“…Cross‐linking of the PCL/GT fibers with glutaraldehyde/ethanol solution for 3 h increased their water contact angle to about 53° ± 2°. This is consistent with the results of others . The PCL/GT/BG nanofiber mats with special micro‐nano morphology had a water contact angle of 0°, the wettability of these fibers did not change even after cross linking.…”

Fabrication and modification of wavy multicomponent vascular grafts with biomimetic mechanical properties, antithrombogenicity, and enhanced endothelial cell affinity

“…Although human endothelial cells can survive on many synthetic material substrates, they usually exhibit slow proliferation rates and migration speeds . Natural materials—such as chitosan, gelatin, collagen, and silk—have all been used in vascular tissue engineering and have shown excellent biocompatibility . However, these natural materials normally have to be combined with synthetic materials like polymers during fabrication due to their intrinsic inferior mechanical properties.…”

“…19,20 Natural materials-such as chitosan, gelatin, collagen, and silk-have all been used in vascular tissue engineering and have shown excellent biocompatibility. 12,17,21,22 However, these natural materials normally have to be combined with synthetic materials like polymers during fabrication due to their intrinsic inferior mechanical properties.…”

Sustained release of stem cell factor in a double network hydrogel for ex vivo culture of cord blood‐derived CD34+ cells

“…It has been proven that the physicochemical property of microenvironment is also a determinant for HSCs behaviours . A lot of efforts have been turned towards developing two‐ and three‐dimensional biomaterials such as microspheres, films, scaffolds and hydrogels for proliferation or differentiation of HSCs .…”

“…It has been proven that the physicochemical property of microenvironment is also a determinant for HSCs behaviours. [21][22][23] A lot of efforts have been turned towards developing two-and three-dimensional biomaterials such as microspheres, films, scaffolds and hydrogels for proliferation or differentiation of HSCs. [24][25][26][27] Among them, hydrogels are considered as promising candidates for cells culture due to their adjustable properties and high water content, providing an artificial microenvironment similar to the native Excetral Cellular Matrix (ECM).…”