Electrospun polyurethane-based vascular grafts: physicochemical properties and functioning in vivo

Гостев, А. А.; Chernonosova, Vera S.; Мурашов, И. С.; Sergeevichev, David; Korobeinikov, Alexandr A; Karaskov, Alexandr M; Карпенко, А. А.; Laktionov, Pavel P.

doi:10.1088/1748-605x/ab550c

Cited by 20 publications

(10 citation statements)

References 78 publications

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“…However, most researchers report a more rapid endothelialization rate with a microporous structure instead of a nanofibrous structure. Bergmeister et al 168 studied the effect of graft porosity on cell migration both in vitro and in vivo with fine (2 μm) and coarse mesh (4 μm) electrospun PU grafts. Their results showed that early cell attachment seemed to favor the finer mesh graft over the course mesh in vitro.…”

Section: Strategies To Prevent Intimal Hyperplasia In Vascular Graftsmentioning

confidence: 99%

Review of Polymeric Biomimetic Small-Diameter Vascular Grafts to Tackle Intimal Hyperplasia

2022

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Small-diameter artificial vascular grafts (SDAVG) are used to bypass blood flow in arterial occlusive diseases such as coronary heart or peripheral arterial disease. However, SDAVGs are plagued by restenosis after a short while due to thrombosis and the thickening of the neointimal wall known as intimal hyperplasia (IH). The specific causes of IH have not yet been deduced; however, thrombosis formation due to bioincompatibility as well as a mismatch between the biomechanical properties of the SDAVG and the native artery has been attributed to its initiation. The main challenges that have been faced in fabricating SDAVGs are facilitating rapid re-endothelialization of the luminal surface of the SDAVG and replicating the complex viscoelastic behavior of the arteries. Recent strategies to combat IH formation have been mostly based on imitating the natural structure and function of the native artery (biomimicry). Thus, most recently, developed grafts contain a multilayered structure with a designated function for each layer. This paper reviews the current polymeric, biomimetic SDAVGs in preventing the formation of IH. The materials used in fabrication, challenges, and strategies employed to tackle IH are summarized and discussed, and we focus on the multilayered structure of current SDAVGs. Additionally, the future aspects in this area are pointed out for researchers to consider in their endeavor.

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Section: Strategies To Prevent Intimal Hyperplasia In Vascular Graftsmentioning

confidence: 99%

Review of Polymeric Biomimetic Small-Diameter Vascular Grafts to Tackle Intimal Hyperplasia

2022

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“…The vascular extracellular matrix is the elastic fiber network organized by medial smooth muscle [ 28 ]. Electrospinning technique could make it possible to produce fibrous matrix to mimic biological tissues, and the introduction of extracellular matrix proteins (collagen, fibronectin, and laminin) into the fibers makes these synthetic 3D matrices biocompatible [ 29 ]. Also, electrospun containing materials, PLCL have been shown to have good mechanical strength and tunable biodegradability[ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Bonding of Flexible Membranes for Perfusable Vascularized Networks Patch

Hong

Song

Choi

et al. 2021

Tissue Eng Regen Med

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BACKGROUND: In vitro generation of three-dimensional vessel network is crucial to investigate and possibly improve vascularization after implantation in vivo. This work has the purpose of engineering complex tissue regeneration of a vascular network including multiple cell-type, an extracellular matrix, and perfusability for clinical application. METHODS: The two electrospun membranes bonded with the vascular network shape are cultured with endothelial cells and medium flow through the engineered vascular network. The flexible membranes are bonded by amine-epoxy reaction and examined the perfusability with fluorescent beads. Also, the perfusion culture for 7 days of the endothelial cells is compared with static culture on the engineered vascular network membrane. RESULTS: The engineered membranes are showed perfusability through the vascular network, and the perfused network resulted in more cell proliferation and variation of the shear stress-related genes expression compared to the static culture. Also, for the generation of the complex vascularized network, pericytes are co-cultured with the engineered vascular network, which results in the Collagen I is expressed on the outer surface of the engineered structure. CONCLUSION: This study is showing the perfusable in vitro engineered vascular network with electrospun membrane. In further, the 3D vascularized network module can be expected as a platform for drug screening and regenerative medicine.

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“…23 Medical polyurethanes can be synthesized either in non-biodegradable 24 or biodegradable. 25 Non-biodegradable PUs mostly are generally found applications in the blood contacting devices such as heart valves, 26 vascular grafts, 27 and catheters 28 due to their hemocompatibility. Also their surface can be easily modified with anticoagulants and antithrombogenic agents.…”

Section: Introductionmentioning

confidence: 99%

Coating of silver nanoparticles on polyurethane film surface by green chemistry approach and investigation of antibacterial activity against S. epidermidis

Kara

Aksoy

et al. 2022

Journal of Bioactive and Compatible Polymers

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Silver nanoparticles with potential antibacterial properties are included in biomaterials for the production of medical devices, which are used for diagnoses or treatment purposes. The aim of the current study was coating the polyurethane (PU) films with silver nanoparticles (AgNPs) due to their antibacterial efficacy. PU films were first modified by chitosan (CH), treated with AgNO3 to let CH chelate with silver ions, and then treated with vitamin-C (vit C) or glucose (Glu) to reduce the adsorbed ions to atomic silver to form AgNPs. The surfaces of the films were examined by ATR-FTIR, XPS, XRD, and SEM. Chemical bond formation between CH and Ag ions and AgNPs were determined by ATR-FTIR. Meanwhile, XPS and SEM analyses proved the presence of reduced metallic silver and nanoparticles on the film surfaces, respectively. According to the SEM analyses, a homogeneous distribution of AgNPs, with sizes 99–214 nm and 37–54 nm, on the film surfaces were obtained depending on Glu or vit C reduction, respectively. The films presented excellent antibacterial performance against Gram positive Staphylococcus epidermidis ( S. epidermidis). These results suggested that the mentioned green technology can be easily applied to obtain AgNP coated polymeric surfaces with very high antibacterial efficacy. Although there are some studies dealing with AgNP formation on PU sponges or fibers, to the best of our knowledge, this is the first study showing AgNP formation on the CH conjugated PU films.

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Electrospun polyurethane-based vascular grafts: physicochemical properties and functioning in vivo

Cited by 20 publications

References 78 publications

Review of Polymeric Biomimetic Small-Diameter Vascular Grafts to Tackle Intimal Hyperplasia

Review of Polymeric Biomimetic Small-Diameter Vascular Grafts to Tackle Intimal Hyperplasia

Bonding of Flexible Membranes for Perfusable Vascularized Networks Patch

Coating of silver nanoparticles on polyurethane film surface by green chemistry approach and investigation of antibacterial activity against S. epidermidis

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