Electrospun polyurethane/Eudragit ® L100-55 composite mats for the pH dependent release of paclitaxel on duodenal stent cover application

Aguilar, Ludwig Erik; Unnithan, Afeesh Rajan; Amarjargal, Altangerel; Tiwari, Arjun Prasad; Hong, Seong‐Tshool; Park, Chan Hee; Kim, Cheol Sang

doi:10.1016/j.ijpharm.2014.10.057

Cited by 49 publications

(32 citation statements)

References 24 publications

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“…The premise of pH change in the duodenum can be exploited for the treatment by using the acidic pH as the drug release trigger for BTZ into the target tumor 30 . Also, one example of a pH gradient inside the body is in the duodenum.…”

Section: Resultsmentioning

confidence: 99%

Functionalized Non-vascular Nitinol Stent via Electropolymerized Polydopamine Thin Film Coating Loaded with Bortezomib Adjunct to Hyperthermia Therapy

Aguilar

Tumurbaatar

GhavamiNejad

et al. 2017

Sci Rep

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Gastrointestinal malignancies have been a tremendous problem in the medical field and cover a wide variety of parts of the system, (i.e. esophagus, duodenum, intestines, and rectum). Usually, these malignancies are treated with palliation with the use of non-vascular nitinol stents. However, stenting is not a perfect solution for these problems. While it can enhance the quality of life of the patient, in time the device will encounter problems such as re-occlusion due to the rapid growth of the tumor. In this study, we propose a functionalization technique using electropolymerization of polydopamine directly onto the nitinol stent struts for the combined application of hyperthermia and chemotherapy. The coating was characterized using FESEM, XPS, and FT-IR. Drug release studies show that facile release of the anticancer drug BTZ from the surface of the polydopamine-coated stent could be achieved by the dissociation between catechol groups of polydopamine and the boronic acid functionality of BTZ in a pH-dependent manner. The anti-cancer property was also evaluated, and cytotoxicity on ESO26 and SNU-5 cancer cell lines were observed. Our results suggest that the introduced approach can be considered as a potential method for therapeutic stent application.

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Section: Resultsmentioning

confidence: 99%

Functionalized Non-vascular Nitinol Stent via Electropolymerized Polydopamine Thin Film Coating Loaded with Bortezomib Adjunct to Hyperthermia Therapy

Aguilar

Tumurbaatar

GhavamiNejad

et al. 2017

Sci Rep

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“…49 Electrospun PU-dextran nanofibre mats have been loaded with estradiol (the most bioactive endogenous estrogen) to improve cutaneous wound repair in post-menopausal women; 50 the electrospinning process directly blends the PU and dextran polymers to obtain the optimum physical and biological properties of the fibres. Electrospinning was also used to make a nanofibre composite PU-Eudragit acrylic polymer mat in which the pH dependent release of paclitaxel was investigated; 51 the acrylic polymer allowed release of the drug in the duodenum (mean pH 5.4). Smart sensitive polymers, designed to change properties based of environmental conditions (pH sensitive in this case), have been prepared from PU-N,N-diethylaminoethyl methacrylate hybrids, with rhodamine 6G added as a model drug; 52 loading methods and release mechanisms were discussed.…”

Section: Drug Delivery Vehiclesmentioning

confidence: 99%

Biomedical applications of polyurethane materials and coatings

Joseph

Patel

Wenham

et al. 2018

Transactions of the IMF

139

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Polyurethanes (PUs), formed by the reaction of diisocyanates with polyols (or equivalent) in the presence of a catalyst, have a wide variety of industrial uses. Much recent attention has focused on their biomedical applications, owing to their biocompatibility, biodegradability and tailorable chemical and physical forms. Examples of such application areas include antibacterial surfaces and catheters, drug delivery vehicles, stents, surgical dressings/pressure sensitive adhesives, tissue engineering scaffolds and electrospinning, nerve generation, cardiac patches and PU coatings for breast implants. Following a brief introduction to PUs, this review surveys selected articles, mostly from 2014 to 2017, that highlight this diverse range of biomedical applications offered by PU materials and coatings.

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“…Various examples of monolithic or blended nanofibers that can or cannot delay drug release can be found in the literature (68,(95)(96)(97), and although some gastro-resistant coreshell nanofibers have been developed (91,93), they are not a general solution for all drugs (92). Thus, delayed release does not depend only on the composition, structure, presence of drug on the nanofiber surface, or defects in the shell of the nanofibers, but also on the drug properties, including its solubility at low pH, molecular weight, and interactions with the polymer (18,68,92,(95)(96)(97).…”

Section: Delayed Drug Releasementioning

confidence: 99%

Core-shell nanofibers as drug delivery systems

Zupančič

2019

Acta Pharmaceutica

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Core-shell nanofibers have grown in popularity over the last decade owing to their special features and their many applications in biomedicine. They can be produced by electrospinning of immiscible polymer blends or emulsions through a single nozzle or by electrospinning using a coaxial nozzle. Several of the electrospinning parameters allow great versatility for the compositions and diameters of core-shell nanofibers to be produced. Morphology of core-shell nanofibers can be investigated using transmission electron microscopy and, in some cases, scanning electron microscopy. Several studies have shown that core-shell nanofibers have some advantages over monolithic nanofibers, such as better drug, protein, gene or probiotic incorporation into the nanofibers, greater control over drug release, and maintenance of protein structure and activity during electrospinning. We herein review the production and characterization of core-shell nanofibers, the critical parameters that affect their development, and their advantages as delivery systems.

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Electrospun polyurethane/Eudragit ® L100-55 composite mats for the pH dependent release of paclitaxel on duodenal stent cover application

Cited by 49 publications

References 24 publications

Functionalized Non-vascular Nitinol Stent via Electropolymerized Polydopamine Thin Film Coating Loaded with Bortezomib Adjunct to Hyperthermia Therapy

Functionalized Non-vascular Nitinol Stent via Electropolymerized Polydopamine Thin Film Coating Loaded with Bortezomib Adjunct to Hyperthermia Therapy

Biomedical applications of polyurethane materials and coatings

Core-shell nanofibers as drug delivery systems

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