Electrospun PVA-Dacarbazine nanofibers as a novel nano brain-implant for treatment of glioblastoma: in silico and in vitro characterization

Steffens, Luiza; Morás, Ana Moira; Arantes, Pablo Ricardo; Masterson, Kevin; Cao, Zhi; Nugent, Michael; Moura, Dinara Jaqueline

doi:10.1016/j.ejps.2019.105183

Cited by 36 publications

(17 citation statements)

References 94 publications

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“… 13 Commonly used biodegradable (or soluble), biocompatible, and U.S. Food and Drug Administration (FDA)-approved polymers include poly(lactic acid) (PLA), poly(vinyl alcohol) (PVA), and poly(caprolactone) (PCL). 5 , 14 − 16 These polymers have been widely used for biomedical applications including cardiovascular stents 15 and implants. 5 , 14 , 16 , 17 …”

Section: Introductionmentioning

confidence: 99%

Poly(caprolactone)-Based Coatings on 3D-Printed Biodegradable Implants: A Novel Strategy to Prolong Delivery of Hydrophilic Drugs

et al. 2020

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Implantable devices are versatile and promising drug delivery systems, and their advantages are well established. Of these advantages, long-acting drug delivery is perhaps the most valuable. Hydrophilic compounds are particularly difficult to deliver for prolonged times. This work investigates the use of poly(caprolactone) (PCL)-based implant coatings as a novel strategy to prolong the delivery of hydrophilic compounds from implantable devices that have been prepared by additive manufacturing (AM). Hollow implants were prepared from poly(lactic acid) (PLA) and poly(vinyl alcohol) (PVA) using fused filament fabrication (FFF) AM and subsequently coated in a PCL-based coating. Coatings were prepared by solution-casting mixtures of differing molecular weights of PCL and poly(ethylene glycol) (PEG). Increasing the proportion of low-molecular-weight PCL up to 60% in the formulations decreased the crystallinity by over 20%, melting temperature by over 4 °C, and water contact angle by over 40°, resulting in an increased degradation rate when compared to pure high-molecular-weight PCL. Addition of 30% PEG to the formulation increased the porosity of the formulation by over 50% when compared to an equivalent PCL-only formulation. These implants demonstrated in vitro release rates for hydrophilic model compounds (methylene blue and ibuprofen sodium) ranging from 0.01 to 34.09 mg/day, depending on the drug used. The versatility of the devices produced in this work and the range of release rates achievable show great potential. Implants could be specifically developed in order to match the specific release rate required for a number of drugs for a wide range of conditions.

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Section: Introductionmentioning

confidence: 99%

Poly(caprolactone)-Based Coatings on 3D-Printed Biodegradable Implants: A Novel Strategy to Prolong Delivery of Hydrophilic Drugs

et al. 2020

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“…Docking calculations were performed with AutoDock Vina (v.1.2.1, Scripps Research, San Diego, CA, USA) [ 38 ]. The structure of PVA was obtained from a previous work [ 15 ]. AutoDock Vina operates by performing a conformational search approach that is gradient based.…”

Section: Methodsmentioning

confidence: 99%

“…Furthermore, PVA’s major functional group is composed of hydroxyl groups that indicate a strong chemical resistance while also relating to its blending ability to other synthetic and natural polymers [ 17 , 18 , 19 , 20 ]. As a result of these features, PVA has been used for drug delivery and tissue scaffolds [ 15 , 21 , 22 , 23 , 24 , 25 ]. Microspheres and hydrogels based on PVA can be prepared by subjecting PVA solution to repeated freeze–thaw cycles, where physical crosslinking occurs through hydrogen bonding based on ice crystal growth [ 11 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Development, Characterization and Cell Viability Inhibition of PVA Spheres Loaded with Doxorubicin and 4′-Amino-1-Naphthyl-Chalcone (D14) for Osteosarcoma

et al. 2021

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Chalcones (1,3-diaryl-2-propen-1-ones) are naturally occurring polyphenols with known anticancer activity against a variety of tumor cell lines, including osteosarcoma (OS). In this paper, we present the preparation and characterization of spheres (~2 mm) from polyvinyl alcohol (PVA) containing a combination of 4′-Amino-1-Naphthyl-Chalcone (D14) and doxorubicin, to act as a new polymeric dual-drug anticancer delivery. D14 is a potent inhibitor of osteosarcoma progression and, when combined with doxorubicin, presents a synergetic effect; hence, physically crosslinked PVA spheres loaded with D14 and doxorubicin were prepared using liquid nitrogen and six freeze–thawing cycles. Physical-chemical characterization using a scanning electron microscope (SEM), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) presented that the drugs were incorporated into the spheres via weak interactions between the drugs and the polymeric chains, resulting in overall good drug stability. The cytotoxicity activity of the PVA spheres co-encapsulating both drugs was tested against the U2OS human osteosarcoma cell line by 3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide (MTT) assay, and compared to the spheres carrying either D14 or doxorubicin alone. The co-delivery showed a cytotoxic effect 2.6-fold greater than doxorubicin alone, revealing a significant synergistic effect with a coefficient of drug interaction (CDI) of 0.49. The obtained results suggest this developed PVA sphere as a potential dual-drug delivery system that could be used for the prominent synergistic anticancer activity of co-delivering D14 and doxorubicin, providing a new potential strategy for improved osteosarcoma treatment.

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“…For instance, poly(lactide-co-glycolide) (PLGA) fibres loaded with the anticancer drug paclitaxel resulted in release sustained for more than 60 days and could be used to effectively treat glioma tumours. 22 In other work, dacarbazine-loaded fibres were explored as an implant for the treatment of brain tumours and found to be effective in vitro, 23 and disulfiramloaded fibres were also shown to be potent against lung cancer cells in vitro. 24 Several recent reviews discuss the applications of electrospinning in cancer therapy in more detail.…”

Section: Monoaxial Electrospinning Of Small Molecule Drugsmentioning

confidence: 99%

Electrospinning for healthcare: recent advancements

Dziemidowicz

Sang

et al. 2021

J. Mater. Chem. B

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Electrospun PVA-Dacarbazine nanofibers as a novel nano brain-implant for treatment of glioblastoma: in silico and in vitro characterization

Cited by 36 publications

References 94 publications

Poly(caprolactone)-Based Coatings on 3D-Printed Biodegradable Implants: A Novel Strategy to Prolong Delivery of Hydrophilic Drugs

Poly(caprolactone)-Based Coatings on 3D-Printed Biodegradable Implants: A Novel Strategy to Prolong Delivery of Hydrophilic Drugs

Development, Characterization and Cell Viability Inhibition of PVA Spheres Loaded with Doxorubicin and 4′-Amino-1-Naphthyl-Chalcone (D14) for Osteosarcoma

Electrospinning for healthcare: recent advancements

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