Electrospun submicron bioactive glass fibers for bone tissue scaffold

Lu, Haiyang; Zhang, T.; Wang, X. P.; Qian, Fang

doi:10.1007/s10856-008-3649-1

Cited by 72 publications

(64 citation statements)

References 33 publications

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“…The mechanical properties of the scaffolds obtained from 70S30C nanofibers were measured by nanoindentation. It was found that the elastic modulus of the scaffold was close to that of trabecular bone [57].…”

Section: Sol-gel Techniquesmentioning

confidence: 83%

“…Similarly to conventional sol-gel synthesis, sol-gel derived and electrospun fibers must be submitted to heat-treatment to remove organic additives. Electrospinning of sol-gel precursors can result in bioactive glass fibers with diameters < 100 nm [55][56][57]. The diameter and the morphology of the nanofibres can be controlled to some extent by the amount and type of additive and the applied electric field.…”

Section: Sol-gel Techniquesmentioning

confidence: 99%

“…The distribution of the fiber diameter was reported to be between 50 and 110 nm, with average diameter 85 nm. More recently, Lu et al [57] have developed bioactive glass nanofibres in the CaO-SiO 2 system (70S30C,70 mol% SiO 2 , 30 mol% CaO) by electrospinning method. A highly porous microstructure with interconnected macropores and mesopores was obtained in the nanofibrous scaffold ( Figure 5).…”

Section: Sol-gel Techniquesmentioning

confidence: 99%

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Polymer/bioactive glass nanocomposites for biomedical applications: A review

Boccaccını

Erol

Stark

et al. 2010

Composites Science and Technology

472

287

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. The physico-chemical, mechanical, and biological advantages of incorporating nanoscale bioactive glasses in such biodegradable nanocomposites are discussed and the possibilities to expand the use of these materials in other nanotechnology concepts aimed to be used in different biomedical applications are also highlighted. ACCEPTED MANUSCRIPT

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Section: Sol-gel Techniquesmentioning

confidence: 83%

Section: Sol-gel Techniquesmentioning

confidence: 99%

Section: Sol-gel Techniquesmentioning

confidence: 99%

See 1 more Smart Citation

Polymer/bioactive glass nanocomposites for biomedical applications: A review

Boccaccını

Erol

Stark

et al. 2010

Composites Science and Technology

472

287

View full text Add to dashboard Cite

show abstract

“…To our best knowledge, among the different techniques used to produce BG-polymer composites [1,11,13], up to now, electrospinning has only been applied with sodium-free bioactive glass [27][28][29][30][31][32][33][34]. Usually, the electrospinning solution was obtained by mixing a solgel precursor of BG with a polymer solution.…”

Section: Introductionmentioning

confidence: 99%

pH-dependent antibacterial effects on oral microorganisms through pure PLGA implants and composites with nanosized bioactive glass

et al. 2013

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Biomaterials made of biodegradable poly(-hydroxyesters) such as poly(lactide-co-glycolide) (PLGA) are known to decrease the pH in the vicinity of the implants. Bioactive glass (BG) is being investigated as a counteracting agent buffering the acidic degradation products. However, in dentistry the question arises whether an antibacterial effect is rather obtained from pure PLGA or from BG/PLGA composites, as BG has been proved to be antimicrobial. In the present study the antimicrobial properties of electrospun PLGA and BG45S5/PLGA fibres were investigated using human oral bacteria (specified with mass spectrometry) incubated for up to 24 h. BG45S5 nanoparticles were prepared by flame spray synthesis. The change in colony-forming units (CFU) of the bacteria was correlated with the pH of the medium during incubation. The morphology and structure of the scaffolds as well as the appearance of the bacteria were followed bymicroscopy. Additionally, we studied if the presence of BG45S5 had an influence on the degradation speed of the polymer. Finally, it turned out that the pH increase induced by the presence of BG45S5 in the scaffold did not last long enough to show a reduction in CFU. On the contrary, pure PLGA demonstrated antibacterial properties that should be taken into consideration when designing biomaterials for dental applications. AbstractBiomaterials made of biodegradable poly(α-hydroxyesters) like poly(lactide-co-glycolide) (PLGA) are known to decrease the pH in the vicinity of the implants. Bioactive glass (BG) is being investigated as a counteracting agent buffering the acidic degradation products.However, in dentistry the question arises whether an antibacterial effect is rather obtained from pure PLGA or from BG/PLGA composites, as BG has been proved antimicrobial. In the present study the antimicrobial properties of electrospun PLGA and BG45S5/PLGA fibres were investigated using human oral bacteria (specified with mass spectrometry) incubated for up to 24 h. BG45S5 nanoparticles were prepared by flame spray synthesis. The change in colony-forming units (CFU) of the bacteria was put into correlation with the pH of the medium during incubation. Morphology and structure of the scaffolds as well as the appearance of the bacteria were followed by microscopy. Additionally, we studied if the presence of BG45S5 had an influence on the degradation speed of the polymer. Finally, it turned out that the pH increase induced by BG45S5 presence in the scaffold did not last long enough to show a reduction in CFU. On the contrary, pure PLGA demonstrated antibacterial properties that should be taken into consideration when designing biomaterials for dental applications.

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“…The flying time of the jet should thus be long enough to enable its complete drying out. Fibers are deposited either as random or aligned mats, by using immobile or rotary collectors respectively [168,169].…”

Section: Electrospinningmentioning

confidence: 99%

Hybrid Organic-Inorganic Scaffolding Biomaterials for Regenerative Therapies

Sachot¹,

Engel²,

Castaño

2014

COC

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Abstract:The introduction of hybrid materials in regenerative medicine has solved some problems related to the mechanical and bioactive properties of biomaterials. Calcium phosphates and their derivatives have provided the basis for inorganic components, thanks to their good bioactivity, especially in bone regeneration. When mixed with biodegradable polymers, the result is a synergic association that mimics the composition of many tissues of the human body and, additionally, exhibits suitable mechanical properties. Together with the development of nanotechnology and new synthesis methods, hybrids offer a promising option for the development of a third or fourth generation of smart biomaterials and scaffolds to guide the regeneration of natural tissues, with an optimum efficiency/cost ratio. Their potential bioactivity, as well as other valuable features of hybrids, open promising new pathways for their usein bone regeneration and other tissue repair therapies. This review provides a comprehensive overview of the different hybrid organic-inorganic scaffolding bio-materials developed so far for regenerative therapies, especially in bone. It also looks at the potential for research into hybrid materials for other, softer tissues, which is still at an initial stage, but with very promising results.

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Electrospun submicron bioactive glass fibers for bone tissue scaffold

Cited by 72 publications

References 33 publications

Polymer/bioactive glass nanocomposites for biomedical applications: A review

Polymer/bioactive glass nanocomposites for biomedical applications: A review

pH-dependent antibacterial effects on oral microorganisms through pure PLGA implants and composites with nanosized bioactive glass

Hybrid Organic-Inorganic Scaffolding Biomaterials for Regenerative Therapies

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