Electrospun UV-cross-linked polyvinylpyrrolidone fibers modified with polycaprolactone/polyethersulfone microspheres for drug delivery

Mirek, A.; Grzeczkowicz, Marcin; Belaid, Habib; Bartkowiak, Aleksandra; Barranger, Fanny; Abid, Mahmoud; Wasyłeczko, Monika; Pogorielov, Мaksym; Bechelany, Mikhael; Lewińska, Dorota

doi:10.1016/j.bioadv.2023.213330

Cited by 13 publications

(3 citation statements)

References 48 publications

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“…For PVP thin films, a common method used is crosslinking by introducing a photoinitiator (hydrogen peroxide or benzophenone) into the film, and/or using UV exposure [38][39][40][41]. In this work, benzophenone was used as an initiator.…”

Section: Preparation Of Water-insoluble Pvp Filmsmentioning

confidence: 99%

“…This excitation leads to the generation of a ketyl radical, which engages with the PVP molecule [40,42]. Typically, the carbon atom adjacent to the nitrogen atom in the lactam ring and the carbon atom in the polymer chain bearing the lactam ring are the two possible locations for radical production in the PVP molecule that occurs due to the hydrogen atom abstraction [39]. Eventually, all the generated radicals recombine, forming a polymer network through various crosslinking bonds.…”

Section: Preparation Of Water-insoluble Pvp Filmsmentioning

confidence: 99%

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Engineered Nanocomposite Coatings: From Water-Soluble Polymer to Advanced Hydrophobic Performances

Jebali,

Vayer,

Belal

et al. 2024

Materials

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In this work, a water-soluble (hydrophilic) polymer was used to form a hydrophobic coating on silicon substrates (Si) in a two-step process comprising (i) the transformation of the polymer into an insoluble material and (ii) the structuring of this coating at nanometric and micrometric scales to achieve the desired hydrophobic behavior. Polyvinylpyrrolidone (PVP), a water-soluble commodity polymer, was crosslinked using benzophenone and UV irradiation to produce a water-insoluble PVP coating. The nanometric scale roughness of the coating was achieved by the addition of silica nanoparticles (NPs) in the coating. The micrometric scale roughness was achieved by forming vertical pillars of PVP/NP coating. To prepare these pillars, a perforated polystyrene (PS) template was filled with a PVP/NP suspension. Micrometer scale vertical pillars of PVP/silica NPs were produced by this method, which allowed us to tune the wettability of the surface, by combining the micrometric scale roughness of the pillars to the nanometric scale roughness provided by the nanoparticles at the surface. By adjusting the various experimental parameters, a hydrophobic PVP coating was prepared with a water contact angle of 110°, resulting in an improvement of more than 80% compared to the bare flat film with an equal amount of nanoparticles. This study paves the way for the development of a more simplified experimental approach, relying on a blend of polymers containing PVP and NPs, to form the micro/nano-structured PVP pillars directly after the deposition step and the selective etching of the sacrificial major phase.

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Section: Preparation Of Water-insoluble Pvp Filmsmentioning

confidence: 99%

Section: Preparation Of Water-insoluble Pvp Filmsmentioning

confidence: 99%

Engineered Nanocomposite Coatings: From Water-Soluble Polymer to Advanced Hydrophobic Performances

Jebali,

Vayer,

Belal

et al. 2024

Materials

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“…while pulsed voltage (PV) is used much less frequently [12][13][14][15]. In the second process variant, an electrical voltage is applied to the nozzle in the form of pulses of a preset frequency and pulse duration.…”

Section: Introductionmentioning

confidence: 99%

Effect of pulsed electrospinning process variables on the size of polymer fibers established with a 2³ factorial design

Bartkowiak,

Grzeczkowicz,

Lewińska

2024

Preprint

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In the present study, the influence of electrical parameters of the pulsed electrospinning process, such as electrical voltage, frequency of the pulses and pulse duration on the structure of the nonwovens obtained was determined for the first time. It was found that all the parameters studied strongly influence the average diameter of the fibres obtained, and that the pulsed electrospinning process carried out under specific conditions makes it possible to obtain, among other things, bimodal nonwovens. In addition, a 23 factorial design was used to determine how the selected electrical parameters of the pulsed electrospinning process affect the structure of the resulting electrospun mats. It was shown, among other things, that by appropriately selecting the parameters of the electrospinning process, the thickness of the fibres can be controlled, resulting in nonwovens with the desired morphology.

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Classes/types of polymers used in oral delivery (natural, semisynthetic, synthetic), their chemical structure and general functionalities

Datta,

Colaco,

Bandi

et al. 2025

Polymers for Oral Drug Delivery Technologies

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Electrospun UV-cross-linked polyvinylpyrrolidone fibers modified with polycaprolactone/polyethersulfone microspheres for drug delivery

Cited by 13 publications

References 48 publications

Engineered Nanocomposite Coatings: From Water-Soluble Polymer to Advanced Hydrophobic Performances

Engineered Nanocomposite Coatings: From Water-Soluble Polymer to Advanced Hydrophobic Performances

Effect of pulsed electrospinning process variables on the size of polymer fibers established with a 2³ factorial design

Classes/types of polymers used in oral delivery (natural, semisynthetic, synthetic), their chemical structure and general functionalities

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Electrospun UV-cross-linked polyvinylpyrrolidone fibers modified with polycaprolactone/polyethersulfone microspheres for drug delivery

Cited by 13 publications

References 48 publications

Engineered Nanocomposite Coatings: From Water-Soluble Polymer to Advanced Hydrophobic Performances

Engineered Nanocomposite Coatings: From Water-Soluble Polymer to Advanced Hydrophobic Performances

Effect of pulsed electrospinning process variables on the size of polymer fibers established with a 23 factorial design

Classes/types of polymers used in oral delivery (natural, semisynthetic, synthetic), their chemical structure and general functionalities

Contact Info

Product

Resources

About

Effect of pulsed electrospinning process variables on the size of polymer fibers established with a 2³ factorial design