Electrostatic assembly of gold nanoparticle and metal–organic framework nanoparticles attenuates amyloid β aggregate-mediated neurotoxicity

Yang, Licong; Chen, Yutong; Zhi, Junge; Yuan, Xiaoyu; Liu, Jie

doi:10.1039/d3tb00281k

Cited by 4 publications

(2 citation statements)

References 49 publications

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“…Cell viability studies demonstrated no cytotoxicity [294] Engineered gold NPs NPs with a diameter of1-2 nm showed toxicity due to irreversible binding. No toxicity was observed in the case of NPs of the range of3-100 nm [142] Metal oxide NPs (TiO…”

Section: Surface-modified Gold Nps Of Various Sizesmentioning

confidence: 99%

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Intranasal Drug Delivery by Nanotechnology: Advances in and Challenges for Alzheimer’s Disease Management

Dighe,

Jog,

Momin

et al. 2023

Pharmaceutics

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Alzheimer’s disease, a progressive neurodegenerative condition, is characterized by a gradual decline in cognitive functions. Current treatment approaches primarily involve the administration of medications through oral, parenteral, and transdermal routes, aiming to improve cognitive function and alleviate symptoms. However, these treatments face limitations, such as low bioavailability and inadequate permeation. Alternative invasive methods, while explored, often entail discomfort and require specialized assistance. Therefore, the development of a non-invasive and efficient delivery system is crucial. Intranasal delivery has emerged as a potential solution, although it is constrained by the unique conditions of the nasal cavity. An innovative approach involves the use of nano-carriers based on nanotechnology for intranasal delivery. This strategy has the potential to overcome current limitations by providing enhanced bioavailability, improved permeation, effective traversal of the blood–brain barrier, extended retention within the body, and precise targeting of the brain. The comprehensive review focuses on the advancements in designing various types of nano-carriers, including polymeric nanoparticles, metal nanoparticles, lipid nanoparticles, liposomes, nanoemulsions, Quantum dots, and dendrimers. These nano-carriers are specifically tailored for the intranasal delivery of therapeutic agents aimed at combatting Alzheimer’s disease. In summary, the development and utilization of intranasal delivery systems based on nanotechnology show significant potential in surmounting the constraints of current Alzheimer’s disease treatment strategies. Nevertheless, it is essential to acknowledge regulatory as well as toxicity concerns associated with this route; meticulous consideration is required when engineering a carrier. This comprehensive review underscores the potential to revolutionize Alzheimer’s disease management and highlights the importance of addressing regulatory considerations for safe and effective implementations. Embracing this strategy could lead to substantial advancements in the field of Alzheimer’s disease treatment.

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Section: Surface-modified Gold Nps Of Various Sizesmentioning

confidence: 99%

“…• Developed PEG-MIL 101-AuNPs demonstrated a marked decline in fibrillation by disrupting Aβ 42 fibrils, thereby decreasing the aggregation[142] …”

mentioning

confidence: 99%

Intranasal Drug Delivery by Nanotechnology: Advances in and Challenges for Alzheimer’s Disease Management

Dighe,

Jog,

Momin

et al. 2023

Pharmaceutics

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From experimental studies to computational approaches: recent trends in designing novel therapeutics for amyloidogenesis

Ghosh,

Kundu,

Ganguly

2025

J. Mater. Chem. B

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Gold Nanoparticles in Neurological Diseases: A Review of Neuroprotection

Chiang,

Yang,

Nicol

et al. 2024

IJMS

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This review explores the diverse applications of gold nanoparticles (AuNPs) in neurological diseases, with a specific focus on Alzheimer’s disease (AD), Parkinson’s disease (PD), and stroke. The introduction highlights the pivotal role of neuroinflammation in these disorders and introduces the unique properties of AuNPs. The review’s core examines the mechanisms by which AuNPs exert neuroprotection and anti-neuro-inflammatory effects, elucidating various pathways through which they manifest these properties. The potential therapeutic applications of AuNPs in AD are discussed, shedding light on promising avenues for therapy. This review also explores the prospects of utilizing AuNPs in PD interventions, presenting a hopeful outlook for future treatments. Additionally, the review delves into the potential of AuNPs in providing neuroprotection after strokes, emphasizing their significance in mitigating cerebrovascular accidents’ aftermath. Experimental findings from cellular and animal models are consolidated to provide a comprehensive overview of AuNPs’ effectiveness, offering insights into their impact at both the cellular and in vivo levels. This review enhances our understanding of AuNPs’ applications in neurological diseases and lays the groundwork for innovative therapeutic strategies in neurology.

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Electrostatic assembly of gold nanoparticle and metal–organic framework nanoparticles attenuates amyloid β aggregate-mediated neurotoxicity

Abstract: The deposition of amyloid β (Aβ) is a conventional pathological hallmark of Alzheimer’s disease (AD). Consequently, the inhibition of Aβ aggregation combined with disaggregation of Aβ fibrils is an important...

Cited by 4 publications

References 49 publications

Intranasal Drug Delivery by Nanotechnology: Advances in and Challenges for Alzheimer’s Disease Management

Intranasal Drug Delivery by Nanotechnology: Advances in and Challenges for Alzheimer’s Disease Management

From experimental studies to computational approaches: recent trends in designing novel therapeutics for amyloidogenesis

Gold Nanoparticles in Neurological Diseases: A Review of Neuroprotection

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