2024
DOI: 10.1021/acscatal.4c04964
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Electrostatic Preorganization in Three Distinct Heterogeneous Proteasome β-Subunits

Silvia Ferrer,
Vicent Moliner,
Katarzyna Świderek

Abstract: The origin of the enzyme's powerful role in accelerating chemical reactions is one of the most critical and still widely discussed questions. It is already accepted that enzymes impose an electrostatic field onto their substrates by adopting complex three-dimensional structures; therefore, the preorganization of electric fields inside protein active sites has been proposed as a crucial contributor to catalytic mechanisms and rate constant enhancement. In this work, we focus on three catalytically active βsubun… Show more

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