Electrostatic self-assembly of multilayer copolymeric membranes on the surface of porous tantalum implants for sustained release of doxorubicin

Chen, Muwan

doi:10.2147/ijn.s25918

Cited by 6 publications

(1 citation statement)

References 30 publications

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“…However, based on existing research,28 we know that ion exchange has a certain slow-release effect, but it is not enough. Therefore, this article adopted an electrostatic self-assembly technique to seal/cover the pores on the surface of the nanoporous microspheres to achieve a further slow-release effect 29. The electrostatic self-assembly technique mainly relies on electrostatic interactions between the assembled molecules to deposit polyelectrolytes alternately on the surface of the substrate and spontaneously form self-assembled films with special structures and functions 30,31.…”

Section: Introductionmentioning

confidence: 99%

<p>Construction and in vivo/in vitro evaluation of a nanoporous ion-responsive targeted drug delivery system for recombinant human interferon α-2b delivery</p>

Liu

Zhu

Bao³

et al. 2019

IJN

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Background Like most protein macromolecular drugs, the half-life of rhIFNɑ-2b is short, with a low drug utilization rate, and the preparation and release conditions significantly affect its stability. Methods A nanoporous ion-responsive targeted drug delivery system (PIRTDDS) was designed to improve drug availability of rhIFNα-2b and target it to the lung passively with sustained release. Chitosan rhIFNα-2b carboxymethyl nanoporous microspheres (CS-rhIFNα-2b-CCPM) were prepared by the column method. Here, an electrostatic self-assembly technique was undertaken to improve and sustain rhIFNα-2b release rate. Results The size distribution of the microspheres was 5~15 μm, and the microspheres contained nanopores 300~400 nm in diameter. The in vitro release results showed that rhIFNα-2b and CCPM were mainly bound by ionic bonds. After self-assembling, the release mechanism was transformed into being membrane diffusion. The accumulative release amount for 24 hrs was 83.89%. Results from circular dichrogram and SDS-PAGE electrophoresis showed that there was no significant change in the secondary structure and purity of rhIFNα-2b. Results from inhibition rate experiments for A549 cell proliferation showed that the antitumor activity of CS-rhIFNα-2b-CCPM for 24 hrs retained 91.98% of the stock solution, which proved that the drug-loaded nanoporous microspheres maintained good drug activity. In vivo pharmacokinetic experimental results showed that the drugs in CS-rhIFNα-2b-CCPM can still be detected in vivo after 24 hrs, equivalent to the stock solution at 6 hrs, which indicated that CS-rhIFNα-2b-CCPM had a certain sustained-release effect in vivo. The results of in vivo tissue distribution showed that CS-rhIFNα-2b-CCPM was mainly concentrated in the lungs of mice (1.85 times the stock solution). The pharmacodynamics results showed that CS-rhIFNα-2b-CCPM had an obvious antitumor effect, and the tumor inhibition efficiency was 29.2%. Conclusion The results suggested a novel sustained-release formulation with higher drug availability and better lung targeting from CS-rhIFNα-2b-CCPM compared to the reference (the stock solution of rhIFNα-2b), and, thus, should be further studied.

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Section: Introductionmentioning

confidence: 99%

<p>Construction and in vivo/in vitro evaluation of a nanoporous ion-responsive targeted drug delivery system for recombinant human interferon α-2b delivery</p>

Liu

Zhu

Bao³

et al. 2019

IJN

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3D-printed porous tantalum artificial bone scaffolds: fabrication, properties, and applications

Yu,

Xu,

Duan

et al. 2024

Biomed. Mater.

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Porous tantalum scaffolds offer a high degree of biocompatibility and have a low friction coefficient. In addition, their biomimetic porous structure and mechanical properties, which closely resemble human bone tissue, make them a popular area of research in the field of bone defect repair. With the rapid advancement of additive manufacturing, 3D-printed porous tantalum scaffolds have increasingly emerged in recent years, offering exceptional design flexibility, as well as facilitating the fabrication of intricate geometries and complex pore structures that similar to human anatomy. This review provides a comprehensive description of the techniques, procedures, and specific parameters involved in the 3D printing of porous tantalum scaffolds. Concurrently, the review provides a summary of the mechanical properties, osteogenesis and antibacterial properties of porous tantalum scaffolds. The use of surface modification techniques and the drug carriers can enhance the characteristics of porous tantalum scaffolds. Accordingly, the review discusses the application of these porous tantalum materials in clinical settings. Multiple studies have demonstrated that 3D-printed porous tantalum scaffolds exhibit exceptional corrosion resistance, biocompatibility, and osteogenic properties. As a result, they are considered highly suitable biomaterials for repairing bone defects. Despite the rapid development of 3D-printed porous tantalum scaffolds, they still encounter challenges and issues when used as bone defect implants in clinical applications. Ultimately, a concise overview of the primary challenges faced by 3D-printed porous tantalum scaffolds is offered, and corresponding insights to promote further exploration and advancement in this domain are presented.

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Recent advances in bio-functional Ta-based bone materials: materials design and bioactivity

Wu,

Zhao,

Cai

et al. 2024

Int. J. Extrem. Manuf.

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Ta-based materials have gained significant interest for bioimplantable scaffolds because of their appropriate mechanical characteristics and biocompatibility. To overcome the serious limitation of bioinertness, there have been many efforts to enhance the bioactivity and osseointegration of Ta-based scaffolds through morphostructural and surface modifications. As scaffolds are implantable devices, sufficient bioactivity is needed to trigger the cellular functions required for tissue engineering. Consequently, a combination of materials and bioscience is needed to develop efficient Ta-based scaffolds, although reviews of this interdisciplinary field remain limited. This review aims to provide an overview of the main strategies to enhance the bioactivity of Ta-based scaffolds, describing the basic mechanisms and research methods of osseointegration, and the approaches to enhance bioactivity and osseointegration. These approaches are divided into three main sections: (i) alteration of the micromorphology, (ii) customization of the scaffold structure, and (iii) functionalization modifications (through alloying or the addition of surface coatings). Also provided are recent advances regarding biocompatibility assessment in vitro, osseointegration properties in vivo, and clinical trial results.

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Electrostatic self-assembly of multilayer copolymeric membranes on the surface of porous tantalum implants for sustained release of doxorubicin

Cited by 6 publications

References 30 publications

<p>Construction and in vivo/in vitro evaluation of a nanoporous ion-responsive targeted drug delivery system for recombinant human interferon α-2b delivery</p>

<p>Construction and in vivo/in vitro evaluation of a nanoporous ion-responsive targeted drug delivery system for recombinant human interferon α-2b delivery</p>

3D-printed porous tantalum artificial bone scaffolds: fabrication, properties, and applications

Recent advances in bio-functional Ta-based bone materials: materials design and bioactivity

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