Electrosynthesis of<i>N</i>-Methylisatin

Suárez, Jaime; Caram, José Alberto; Echeverría, Gustavo A.; Piro, Oscar E.; Gennaro, Ana María; Mirífico, María Virginia

doi:10.1021/acs.joc.9b00690

Cited by 2 publications

(1 citation statement)

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“…Mirı́fico et al investigated the electroreduction mechanism of isatin ( 35 , ISH) in 0.1 M NaClO 4 –DMF at a vitreous carbon electrode in the presence of CH 3 I (Scheme ). Through a one-electron process, 35 is reduced to 35 •– , which can react with either CH 3 I to afford NMI ( 37 ) or 35 to afford ISH – ( 35 – ) and ISH 2 • ( 36 ).…”

Section: Use Of Analytical Methods To Determine Reaction Pathways And...mentioning

confidence: 99%

Versatile Tools for Understanding Electrosynthetic Mechanisms

et al. 2021

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Electrosynthesis is a popular, green alternative to traditional organic methods. Understanding the mechanisms is not trivial yet is necessary to optimize reaction processes. To this end, a multitude of analytical tools is available to identify and quantitate reaction products and intermediates. The first portion of this review serves as a guide that underscores electrosynthesis fundamentals, including instrumentation, electrode selection, impacts of electrolyte and solvent, cell configuration, and methods of electrosynthesis. Next, the broad base of analytical techniques that aid in mechanism elucidation are covered in detail. These methods are divided into electrochemical, spectroscopic, chromatographic, microscopic, and computational. Technique selection is dependent on predicted reaction pathways and electrogenerated intermediates. Often, a combination of techniques must be utilized to ensure accuracy of the proposed model. To conclude, future prospects that aim to enhance the field are discussed.

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Section: Use Of Analytical Methods To Determine Reaction Pathways And...mentioning

confidence: 99%