Electrowetting Behavior and Digital Microfluidic Applications of Fluorescent, Polymer-Encapsulated Quantum Dot Nanofluids

Tohgha, Urice N.; Alvino, Ernest L.; Jarnagin, Clark C; Iacono, Scott T.; Godman, Nicholas P.

doi:10.1021/acsami.9b07983

Cited by 12 publications

(3 citation statements)

References 50 publications

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“…Examples of forking and device modification consist of using the DropBot for enzyme screening ( [21], [25]), or using a different open-source DMF device, the OpenDrop, for DNA storage ( [24], [26]). Likewise, there have been many applications using these open source devices including proof-of-principle fluorescent quantum dot manipulation and cell-free based methods on the OpenDrop ( [27], [28]). As with previous open-source hardware projects, we envision the PhageBox to be extended upon, to enable future collaboration and forking, as well as to push the domain further.…”

Section: System Overviewmentioning

confidence: 99%

PhageBox: An Open Source Digital Microfluidic Extension with Applications for Phage Discovery

Albin¹,

Buecherl²,

Kochavi³

et al. 2023

Preprint

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This work introduces an open-source hardware and software expansion for digital microfluidics (DMF) devices that integrates programmatic temperature and magnetic control. Our aim was to create a versatile, modular, extension that may aid in biomedical applications and has proven potential for use in bacteriophage research. To achieve this, we developed an accessible DMF device extension called PhageBox. PhageBox incorporates temperature and magnetic control modules at the hardware level. At the software level, it is controlled by embedded software that includes a unique model for bio-protocol programming and a graphical user interface for visual feedback and operation of the device. We evaluated PhageBox's effectiveness in biomedical applications using functional testing and validated the temperature control using thermography, achieving a range of +/-0.2 Celsius. The electromagnets produced a magnetic force of 15 milliTesla, which precisely immobilized magnetic beads. Furthermore, we demonstrate the potential of PhageBox in bacteriophage research through three initial proof of principle protocols: (1) a universal framework for PCR, (2) T7 bacteriophage restriction enzyme digestion, and (3) the concentration of PhiX174 RF genomic DNA. Overall, our study presents an open-source solution for DMF devices to integrate temperature regulation and magnetism, facilitating various applications in biomedical research and bacteriophage studies. (GitHub: <a href="https://github.com/Dreycey/PhageBox" target="_blank">https://github.com/Dreycey/PhageBox</a>)

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Section: System Overviewmentioning

confidence: 99%

PhageBox: An Open Source Digital Microfluidic Extension with Applications for Phage Discovery

Albin¹,

Buecherl²,

Kochavi³

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…Another interesting application of electric field-based coating triggering is likely with magnetic field application related to the reversible changing of surface-liquid interaction. In this regard, the well-known electrowetting phenomenon is commonly used [138], where the electric field-induced water precipitation/removal in surface pores or valleys enables the liquid contact angle tuning [139]. As a result, the precise control of the surface wetting is achieved, with related on-demand introduction of superhydrophobicity or water repellence.…”

Section: Electro-responsive Coatingsmentioning

confidence: 99%

Physically Switchable Antimicrobial Surfaces and Coatings: General Concept and Recent Achievements

et al. 2021

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Bacterial environmental colonization and subsequent biofilm formation on surfaces represents a significant and alarming problem in various fields, ranging from contamination of medical devices up to safe food packaging. Therefore, the development of surfaces resistant to bacterial colonization is a challenging and actively solved task. In this field, the current promising direction is the design and creation of nanostructured smart surfaces with on-demand activated amicrobial protection. Various surface activation methods have been described recently. In this review article, we focused on the “physical” activation of nanostructured surfaces. In the first part of the review, we briefly describe the basic principles and common approaches of external stimulus application and surface activation, including the temperature-, light-, electric- or magnetic-field-based surface triggering, as well as mechanically induced surface antimicrobial protection. In the latter part, the recent achievements in the field of smart antimicrobial surfaces with physical activation are discussed, with special attention on multiresponsive or multifunctional physically activated coatings. In particular, we mainly discussed the multistimuli surface triggering, which ensures a better degree of surface properties control, as well as simultaneous utilization of several strategies for surface protection, based on a principally different mechanism of antimicrobial action. We also mentioned several recent trends, including the development of the to-detect and to-kill hybrid approach, which ensures the surface activation in a right place at a right time.

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“…Devices based on electrowetting-on-dielectric (EWOD) are particularly appealing due to the rapid actuation speeds [ 1 , 2 , 3 ], lower power consumption [ 4 ] and the flexibility in the design of the substrates (soft as well as rigid substrates with relatively easy fabrication methods) [ 5 , 6 ]. Electrowetting-on-dielectric (EWOD) represents an electrowetting setup comprising a polar droplet/fluid on an insulating thin-film dielectric material coated on a conductive substrate, whereby the wetting properties of the droplet/fluid can be controlled by applying a voltage between the conductive droplet/fluid and underlying conductive substrate [ 7 , 8 , 9 , 10 , 11 , 12 ]. The EWOD platform also enables practical applications such as visible light and IR light shutters [ 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Switchable Optical Properties of Dyes and Nanoparticles in Electrowetting Devices

Tohgha,

Ly,

Lee

et al. 2024

Nanomaterials

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The optical properties of light-absorbing materials in optical shutter devices are critical to the use of such platforms for optical applications. We demonstrate switchable optical properties of dyes and nanoparticles in liquid-based electrowetting-on-dielectric (EWOD) devices. Our work uses narrow-band-absorbing dyes and nanoparticles, which are appealing for spectral-filtering applications targeting specific wavelengths while maintaining device transparency at other wavelengths. Low-voltage actuation of boron dipyromethene (BODIPY) dyes and nanoparticles (Ag and CdSe) was demonstrated without degradation of the light-absorbing materials. Three BODIPY dyes were used, namely Abs 503 nm, 535 nm and 560 nm for dye 1 (BODIPY-core), 2 (I2BODIPY) and 3 (BODIPY-TMS), respectively. Reversible and low-voltage (≤20 V) switching of dye optical properties was observed as a function of device pixel dimensions (300 × 900, 200 × 600 and 150 × 450 µm). Low-voltage and reversible switching was also demonstrated for plasmonic and semiconductor nanoparticles, such as CdSe nanotetrapods (abs 508 nm), CdSe nanoplatelets (Abs 461 and 432 nm) and Ag nanoparticles (Abs 430 nm). Nanoparticle-based devices showed minimal hysteresis as well as faster relaxation times. The study presented can thus be extended to a variety of nanomaterials and dyes having the desired optical properties.

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Electrowetting Behavior and Digital Microfluidic Applications of Fluorescent, Polymer-Encapsulated Quantum Dot Nanofluids

Cited by 12 publications

References 50 publications

PhageBox: An Open Source Digital Microfluidic Extension with Applications for Phage Discovery

PhageBox: An Open Source Digital Microfluidic Extension with Applications for Phage Discovery

Physically Switchable Antimicrobial Surfaces and Coatings: General Concept and Recent Achievements

Switchable Optical Properties of Dyes and Nanoparticles in Electrowetting Devices

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