Electrozymographic evaluation of the attenuation of arsenic induced degradation of hepatic SOD, catalase in an in vitro assay system by pectic polysaccharides of Momordica charantia in combination with curcumin

Perveen, Hasina; Dash, Moumita; Khatun, Shamima; Maity, Moulima; Islam, Syed S.; Chattopadhyay, Sandip

doi:10.1016/j.bbrep.2017.06.002

Cited by 14 publications

(6 citation statements)

References 69 publications

(70 reference statements)

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“…The effect of “As expulsion therapy” in managing chronic As poisoning is effective but has certain limitations. Research has established that the pectic polysaccharides of Momordica charantia could inhibit the oxidative stress of liver cells induced by sodium arsenite [ 10 ]. Besides, numerous studies have demonstrated that polysaccharides regulate immunity and protect the liver [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

[Retracted] Intervention Study of Dictyophora Polysaccharides on Arsenic‐Induced Liver Fibrosis in SD Rats

Wang

Zuo

Ding

et al. 2022

BioMed Research International

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Long-term arsenic (As) exposure can cause liver injury, hepatic cirrhosis, and cancer. Meanwhile, Dictyophora polysaccharides (DIP) have excellent antioxidation, anti-inflammation, and immune protection effects. There are currently few reports on the protection effects of DIP on As-induced hepatotoxicity and its pharmacological value. Therefore, this study was aimed at elucidating the protection of DIP on As-induced hepatotoxicity and exploring its preventive role in antifibrosis. In our study, the SD rat As poisoning model was established by the feeding method to explore the influence of As exposure on liver fibrosis. Then, DIP treatment was applied to the rats with As-induced liver fibrosis, and the changes of serum biochemical indexes and liver tissue pathology were observed. And the expression of fibrosis-related proteins TGF-β1, CTGF, and α-SMA levels was then determined to explore the DIP intervention function. The results demonstrated that through reduced pathological changes of hepatic and increased serum AST, ALT, TP, ALB, and A/G levels, DIP ameliorated liver fibrosis induced by As as reflected. And the administration of DIP decreased the concentration of HA, LN, PCIII, CIV, TBIL, and DBIL. In addition, the synthesis of TGF-β1 inhibited by DIP might regulate the expression of CTGF and decrease the proliferation of fibrinogen and fibroblasts, which reduced the synthesis of fibroblasts to transform into myofibroblasts. And a decrease of myofibroblasts downregulated the expression of α-SMA, which affected the synthesis and precipitation of ECM and alleviated the liver fibrosis caused by exposure to As. In conclusion, based on the pathological changes of liver tissue, serum biochemical indexes, and related protein expression, DIP can improve the As-induced liver fibrosis in rats and has strong medicinal value.

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Section: Introductionmentioning

confidence: 99%

[Retracted] Intervention Study of Dictyophora Polysaccharides on Arsenic‐Induced Liver Fibrosis in SD Rats

Wang

Zuo

Ding

et al. 2022

BioMed Research International

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“…However, Praveen et al applied a combination of a polysaccharide from Mormodica charantia and curcumin from Curcuma longa to prevent As 3+ degradation of SOD and catalase in the liver. 107 Hepatic tissue MDA and CD levels showed that the coadministration offered better antioxidant effect compared to single applications and the highest restoration of SOD/catalase was recorded in the co-administration experiments.…”

Section: Synergistic Amelioration Of Heavy Metal-induced Diseases Usimentioning

confidence: 92%

Untitled

2020

TJNPR

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contaminants in the environmental systems are the heavy metals which gain access into our environment through natural and human activities such as soil erosion and runoffs , mining and rock weathering, indiscriminate disposal of industrial effluents, sewage discharge, unguided use of pesticides, etc. 1 Although some of these metals are "essential", however, above their permissible limits, such metals become harmful to the body. The WHO permissible limit for cadmium, chromium, copper, lead, manganese and nickel in drinking water are 0.003, 0.05, 2.00, 0.01, 0.50, and 0.02 mg/L, respectively. 2 Above these levels, these metals are no longer beneficial. When aquatic animals ingest heavy metal-contaminated water, they naturally bio-accumulate the metals. Similarly, when plants are irrigated with such water, heavy metal accumulation occurs. The eventual consumption of these is dangerous as it consequently leads to the development of various life-threatening diseases such as cancer and organ damage among others. The threat of heavy metal poisoning is higher for people in rural areas. Particularly, people in neglected parts of developing nations are more prone to such poisoning because of ignorance and lack of potable water supply. 3

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“…MCF-7 cells treated with M. charantia during G2-M phase increased expression of p53 and p21; pChk1/2 inhibited the expression of cyclin B1 and cyclin D1 by involving regulation of cell cycle, thus inhibiting the growth of breast cancer cells [98]. Combination of M. charantia and C. domestica prevented cell damage and provided significant protection against changes in malondialdehyde (MDA), conjugated diene, and defense antioxidants [99]. Tahitian noni dietary supplements can also improve testicular toxicity supplemented with high doses of M. charantia extract [100].…”

Section: Momordica Charantiamentioning

confidence: 99%

Review: Germinal Cell Apoptosis by Herbal Medicine

Situmorang

Ilyas

2018

Asian J Pharm Clin Res

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Apoptosis is a mechanism of cell death with a main role in cell recycling, which occurs in several organs: Testical, placenta, prostate, breast, ovarian, and cancer cells. Apoptotic signal pathway may be used to repair reproductive health disorders. Signal pathway of germ cell usually begins with extrinsic apoptotic pathway involving Fas/FasL molecule and mitochondrial pathway with Bcl-2 protein component. Apoptotic process in germ cell can also be triggered by exposing certain plant secondary metabolite to certain cells. Many plants have been reported successfully triggering apoptotic properties, i.e. (1) Areca catechu, (2) Carica papaya, (3) Camellia sinensis, (4) Curcuma domestica, (5) Costus speciosus, (6) Gossypium hirsutum, (7) Hibiscus spp., (8) Luffa aegyptiaca, (9) Momordica charantia, (10) Nicotiana tabacum, (11) Olea europaea, (12) Ocimum basilicum, and (13) Zingiber officinale. The metabolites may induce apoptosis through upregulating Fas/Fas-L and p53 expression, Bax/Bcl-2, along with caspase-3 activation. The mentioned plants then will induce apoptosis in germ cell and may become promising candidates to treat cancer as evidenced from extensive laboratory studies.

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Electrozymographic evaluation of the attenuation of arsenic induced degradation of hepatic SOD, catalase in an in vitro assay system by pectic polysaccharides of Momordica charantia in combination with curcumin

Cited by 14 publications

References 69 publications

[Retracted] Intervention Study of Dictyophora Polysaccharides on Arsenic‐Induced Liver Fibrosis in SD Rats

[Retracted] Intervention Study of Dictyophora Polysaccharides on Arsenic‐Induced Liver Fibrosis in SD Rats

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Review: Germinal Cell Apoptosis by Herbal Medicine

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