Element distribution in the brain of rats exposed to lanthanum measured by synchrotron radiation X-ray fluorescence

Feng, Liuxing; Xiao, Hansong; He, Xiaobo; Li, Zhangjian; Li, F. L.; Liu, N. Q.; Chai, Zhifang; Zhao, Yuliang; Huang, Yideng; He, Wei; Zhang, Zhi Yong

doi:10.1007/s10967-007-0525-2

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…XRF is also a useful, nondestructive, and multielemental analysis technique, capable of mapping the elemental distribution of NMs/NPs on the whole body scale. ,, Wang et al developed a method to quantify the distribution of TiO 2 NPs using SRXRF and reported that TiO 2 NPs could be translocated to the olfactory bulb through the olfactory nerve system after inhalation . In another study, Feng et al used SRXRF to investigate the effects of lanthanum exposure on regional distribution of inorganic elements in rat brain . Furthermore, the combination of SRXRF with other analytical techniques, such as immunohistochemistry analysis, can provide information on the accumulation of NMs/NPs and the resulted pathological changes in target tissues with enhanced precision.…”

Section: Quantification Of Nanomaterial/nanomedicine Trafficking In Vivomentioning

confidence: 99%

Quantification of Nanomaterial/Nanomedicine Trafficking in Vivo

et al. 2017

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Figure 4. Main techniques for labeling NMs/NPs with isotopes and their applications for quantification of NMs/NPs in vivo. (a) Main methods for labeling NMs/NPs with isotopes. Isotopes can be attached to the surface of NMs/NPs through physical interaction such as electrostatic interaction and π−π interaction (adsorption), metal coordination interaction (coordination), chemical reactions (covalent attachment), doping chemistry (doping), or formation of a shell (core−shell structure).

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Section: Quantification Of Nanomaterial/nanomedicine Trafficking In Vivomentioning

confidence: 99%

Quantification of Nanomaterial/Nanomedicine Trafficking in Vivo

et al. 2017

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“…Many in vitro studies suggested negligible cytotoxicity of UCNPs [18,19]. Nevertheless, possible adverse effects of UCNPs can arise from: (i) the accumulation of dissolved RE and fluoride ions in specific cells and/or (ii) the interaction of RE ions with cellular phosphates and fluoride ions (e.g., with aluminum ions disrupting the cellular phosphates by tetrafluoroaluminate complexes) [6,[20][21][22][23][24]. Various surface functionalization strategies suggested a safe usage of UCNPs in bioapplications [25][26][27][28][29][30], but only Li et al studied the possible interaction of UCNPs with cellular phosphates [26].…”

Section: Introductionmentioning

confidence: 99%

NaYF₄-based upconverting nanoparticles with optimized phosphonate coatings for chemical stability and viability of human endothelial cells

Lisjak¹,

Vozlič²,

Kostiv³

et al. 2021

Methods Appl. Fluoresc.

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The increasing interest in upconverting nanoparticles (UCNPs) in biodiagnostics and therapy fuels the development of biocompatible UCNPs platforms. UCNPs are typically nanocrystallites of rare-earth fluorides codoped with Yb3+ and Er3+ or Tm3+. The most studied UCNPs are based on NaYF4 but are not chemically stable in water. They dissolve significantly in the presence of phosphates. To prevent any adverse effects on the UCNPs induced by cellular phosphates, the surfaces of UCNPs must be made chemically inert and stable by suitable coatings. We studied the effect of various phosphonate coatings on chemical stability and in vitro cytotoxicity of the Yb3+,Er3+-codoped NaYF4 UCNPs in human endothelial cells obtained from cellular line Ea.hy926. Cell viability of endothelial cells was determined using the resazurin-based assay after the short-term (15 min), and long-term (24 h and 48 h) incubations with UCNPs dispersed in the cell-culture medium. The coatings were obtained from tertaphosphonic acid (EDTMP), sodium alendronate, and poly(ethylene glycol)-neridronate. Regardless of the coating conditions, 1−2 nm-thick amorphous surface layers were observed on the UCNPs with transmission electron microscopy. The upconversion fluorescence was measured in the dispersions of all synthesized UCNPs. Surface quenching in aqueous suspensions of the UCNPs was reduced by the coatings. The dissolution degree of the UCNPs was determined from the concentration of dissolved fluoride measured with ion-selective electrode after the aging of UCNPs in water, physiological buffer (i.e., phosphate-buffered saline – PBS), and cell-culture medium. The phosphonate coatings prepared at 80 °C significantly suppressed the dissolution of UCNPs in PBS, while only minor dissolution of bare and coated UCNPs was measured in water and cell-culture medium. The viability of human endothelial cells was significantly reduced when incubated with UCNPs, but it increased with the improved chemical stability of UCNPs by the phosphonate coatings with negligible cytotoxicity when coated with EDTMP at 80 °C.

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Professor Zhifang Chai: Scientific contributions and achievements

Zhao

Chen

Feng

et al. 2022

Chinese Chemical Letters

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Element distribution in the brain of rats exposed to lanthanum measured by synchrotron radiation X-ray fluorescence

Cited by 5 publications

References 7 publications

Quantification of Nanomaterial/Nanomedicine Trafficking in Vivo

Quantification of Nanomaterial/Nanomedicine Trafficking in Vivo

NaYF₄-based upconverting nanoparticles with optimized phosphonate coatings for chemical stability and viability of human endothelial cells

Professor Zhifang Chai: Scientific contributions and achievements

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Element distribution in the brain of rats exposed to lanthanum measured by synchrotron radiation X-ray fluorescence

Cited by 5 publications

References 7 publications

Quantification of Nanomaterial/Nanomedicine Trafficking in Vivo

Quantification of Nanomaterial/Nanomedicine Trafficking in Vivo

NaYF4-based upconverting nanoparticles with optimized phosphonate coatings for chemical stability and viability of human endothelial cells

Professor Zhifang Chai: Scientific contributions and achievements

Contact Info

Product

Resources

About

NaYF₄-based upconverting nanoparticles with optimized phosphonate coatings for chemical stability and viability of human endothelial cells