Element variations in pregnant and nonpregnant female rats orally intoxicated by aluminum lactate

Abstract

Pregnant or nonpregnant female rats were orally intoxicated by aluminum lactate (400 mg Al/kg/d) from d 0-19 of gestation to determine the treatment's influence on element variations in the females and their fetuses. The aluminum levels of plasma, liver, spleen, and kidneys were significantly higher in treated pregnant rats than non-pregnant female rats. Differences of P, Ca, Cu, Zn, or Mg levels were observed among the four groups of female rats in the tissues and plasma. The aluminum content of the 20-d-old fetuses did not significantly differ between the treated and control groups. On the contrary, calcium and magnesium levels in the whole fetuses from treated or nontreated dams are significantly different.

Effect of vitamin E and selenium against aluminum-induced nephrotoxicity in pregnant rats

“…In an earlier study, aluminum levels of plasma, liver, spleen, and kidneys were significantly higher in treated pregnant rats than non-pregnant female rats after oral ingestion of aluminum lactate (400 mg Al/kg/d.) [5]. The primary effects of AlCl 3 on brain [29] and kidney [30] are thought to be mediated via damage to cell membranes.…”

“…Few studies were focused on studying the effect of aluminium on the histological structure of kidney during pregnancy. One of them found that administration of aluminium lactate through gavage during the day 0-19 of gestation caused significantly higher levels of aluminum in plasma, liver, spleen and kidneys of pregnant rats when compared to non-pregnant female rats [5].…”

Effects of Various Aluminium Compounds Given Orally to Mice on Al Tissue Distribution and Tissue Concentrations of Essential Elements

“…The highest concentration of 45 Ca 2π ions was observed in the liver (Anghileri 1992). Muller et al (1993) observed a significant rise of Ca in serum and spleen of adult rats, as well as in newborns whose mothers received oral aluminium lactate. This is in line with data by Severson et al (1992), who reported much lower levels of Ca in the osseous tissue of aluminium-intoxicated animals.…”

“…A decline in the contents of this element was observed by Muller et al (1993) in the kidneys of rats after administration of aluminium compounds.…”

“…Lower Mg concentration in bones is probably not only a result of its lower concentration in blood, but also points to disturbances of Mg metabolism (Allen 1985;Muller et al 1993). It was also noted that Mg level is lower in carcasses of newborn offspring of rats fed aluminium compounds, as these rats also showed lower Mg level in blood (Muller et al 1993).…”