Elemental analysis of fingernail of alcoholic and doping subjects by laser-induced breakdown spectroscopy

Bahreini, Maryam; Ashrafkhani, Behnam; Tavassoli, Seyed Hassan

doi:10.1007/s00340-013-5538-7

Cited by 18 publications

(6 citation statements)

References 32 publications

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“…LIBS has also been tested in a variety of other forensic investigations, including document discrimination [88,209,210], fraud detection of a variety of industrial products [211], soil fingerprinting [212,213], and the study of human remains [214,215] or of samples taken from suspects [216]. The success of all these applications heavily relies on the performance of the multivariate chemometric methods used.…”

Section: Forensic Analysismentioning

confidence: 99%

A critical review of recent progress in analytical laser-induced breakdown spectroscopy

Galbács

2015

Anal Bioanal Chem

173

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Laser-induced breakdown spectroscopy (LIBS) has become an established analytical atomic spectrometry technique and is valued for its very compelling set of advantageous analytical and technical characteristics. It is a rapid, versatile, non-contact technique, which is capable of providing qualitative and quantitative analytical information for practically any sample, in a virtually non-destructive way, without any substantial sample preparation. The instrumentation is simple, robust, compact, and even enables remote analysis. This review attempts to give a critical overview of the diverse progress of the field, focusing on the results of the last five years. The advancement of LIBS instrumentation and data evaluation is discussed in detail and selected results of some prominent applications are also described.

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Section: Forensic Analysismentioning

confidence: 99%

A critical review of recent progress in analytical laser-induced breakdown spectroscopy

Galbács

2015

Anal Bioanal Chem

173

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“…Emissions of excited atoms, ions, and molecules in this plasma are recorded as a spectrum and analyzed for atomic identification of the sample. In recent years, this technique is mostly used for analysis of different tissues, including hard tissues such as hair, 11 nails [12][13][14][15][16][17][18] and teeth [19][20][21][22] and soft tissues such as blood, 23 cervical, 24 liver 25 and colorectal tissues. 26 What sets this method apart from other conventional methods is the convenience of sample preparation, higher speed of performance and no direct connection with samples especially contaminant materials.…”

Section: Introductionmentioning

confidence: 99%

Feasibility Study on Discrimination of Neo-plastic and Non-Neoplastic Gastric Tissues Using Spark Discharge Assisted Laser Induced Breakdown Spectroscopy

et al. 2018

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Introduction: The present work is a novel in vitro study that evaluated the possibility of diagnosing neoplastic from nonneoplastic gastric tissues using spark discharge assisted laser induced breakdown spectroscopy (SD-LIBS) method. Methods: In these experiments, the low energy laser pulses ablated a tiny amount of tissue surface leading to plasma formation. Then, a spark discharge was applied to plasma in order to intensify the plasma radiation. Light emission from plasma was recorded as spectra which were analyzed. Gastric tissues of 5 people were studied through this method. Results: The SD-LIBS technique had the potential to discriminate normal and cancerous tissues based on the significant differences in the intensities of some particular elements. The comparison of normalized calcium (Ca) and magnesium (Mg) peaks of neoplastic and nonneoplastic gastric tissues could be viewed as a practical measure for tissue discrimination since Ca and Mg peaks in spectra of neoplastic were noticeably higher than nonneoplastic. Conclusion: Considering the identification of gastric cancer, the applied method in these experiments seems quite fast, noninvasive and cost-effective with respect to other conventional methods. The significant increment of specific Ca and Mg lines of neoplastic gastric tissues in comparison to the nonneoplastic ones can be considered as valuable information that might bring about tissue classification. The number of samples in this work, however, was not sufficient for a decisive conclusion and further researches is needed to generalize this idea.

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“…To investigate alcoholic and doping subjects, an auto-focus system was applied to prepare the same lens to sample distance for all fingernails. 13 Since in that work the sample size was so limited, we could not make a general conclusion from our results. So, in the present study, in addition to using the auto-focus system, a reasonable sample size is prepared.…”

Section: Introductionmentioning

confidence: 79%

“…1,2 There is a special attention on the application of LIBS in biological matrix analysis. Analysis of bacteria, 3,4 teeth, 5,6 hairs, 7 bones, 8 and fingernails [9][10][11][12][13] are some examples of its applications in this area. Other methods used for elemental analysis of biological matrix are neutron activation analysis, 14 atomic absorption spectrophotometry, 15 inductively coupled plasma mass spectrometry, 16 X-ray fluorescence, 17 and proton particle-induced X-ray emission, 18 whereas Raman spectroscopy is extensively used as a molecular detection method.…”

Section: Introductionmentioning

confidence: 99%

“…Elemental analyses of fingernails of opium addicts, osteoporotic, hyper-and hypothyroidism, alcoholic, and doping subjects by means of LIBS have been investigated by our group. [10][11][12][13] In our previous works, we could find some correlation between disease and fingernail elements. To investigate alcoholic and doping subjects, an auto-focus system was applied to prepare the same lens to sample distance for all fingernails.…”

Section: Introductionmentioning

confidence: 99%

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Discrimination of patients with diabetes mellitus and healthy subjects based on laser-induced breakdown spectroscopy of their fingernails

2013

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Laser-induced breakdown spectroscopy (LIBS) is applied to investigate the effect of diabetes mellitus (DM) on the elemental composition of fingernails. Measurements are carried out on 85 fingernail clippings including 51 diabetic and 34 control subjects. An auto-focus system has been designed and used in experiments to improve the repeatability of LIBS measurements. Classification of diabetic and nondiabetic subjects is examined using discriminant function analysis (DFA) method. This classification is based on 82 atomic, ionic, and molecular emission lines belonging to 13 elements as well as one molecule of fingernails. Emission lines that can be used as the best predictors are identified. The possibility of using this method for screening purposes is discussed based on the classification results. This preliminary work shows the ability of LIBS of fingernails in discrimination of DM patients and nondiabetic subjects using DFA method and its feasibility in screening purposes.

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Elemental analysis of fingernail of alcoholic and doping subjects by laser-induced breakdown spectroscopy

Cited by 18 publications

References 32 publications

A critical review of recent progress in analytical laser-induced breakdown spectroscopy

A critical review of recent progress in analytical laser-induced breakdown spectroscopy

Feasibility Study on Discrimination of Neo-plastic and Non-Neoplastic Gastric Tissues Using Spark Discharge Assisted Laser Induced Breakdown Spectroscopy

Discrimination of patients with diabetes mellitus and healthy subjects based on laser-induced breakdown spectroscopy of their fingernails

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