Elemental analysis of organic compounds with the use of automated CHNS analyzers

Fadeeva, V. P.; Тихова, В. Д.; Nikulicheva, O. N.

doi:10.1134/s1061934808110142

Cited by 173 publications

(69 citation statements)

References 18 publications

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“…During the combustion process taking place in a furnace (at ca. 1000°C), carbon is converted to carbon dioxide, hydrogen to water, nitrogen to nitrogen gas or oxides of nitrogen and sulphur to sulphur dioxide [90]. If other elements such as halide are present, they will also be converted to their corresponding combustion products, such as hydrogen halide.…”

Section: Elemental Analysismentioning

confidence: 98%

Organoclay-modified electrodes: preparation, characterization and recent electroanalytical applications

Tonlé

Ngameni

Tchieno

et al. 2015

J Solid State Electrochem

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Amperometric sensors dedicated to the determination of pollutants and other compounds of interest face daily a great challenge: the development of sensitive, reproducible and low-cost devices allowing fast analyses. This review deals with the beneficial role and application of organoclays exploited as sensing materials in various fields of electroanalysis, for the past 15 years (period 2000-2014). After a description of different preparation methods leading to clay minerals chemically modified by organic compounds, the common methods used for their characterization are exposed; then, their application as electrode modifiers is described, covering several approaches that were developed to enhance either the sensitivity or the selectivity of the indexed organoclay-based sensors. Finally, a brief description of voltammetric methods frequently used for electroanalytical purposes is given, followed by an update of recent and salient results achieved for the detection of inorganic and organic electroactive compounds or ions.

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Section: Elemental Analysismentioning

confidence: 98%

Organoclay-modified electrodes: preparation, characterization and recent electroanalytical applications

Tonlé

Ngameni

Tchieno

et al. 2015

J Solid State Electrochem

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“…Modern studies typically apply commercial CHN(O) analyzers that employ flash heating to 900-1000 1C, followed by catalytic oxidation and reduction reactions in an inert gas stream. 70 Thermogravimetric analysis (TGA) is also applied during controlled step heating combined with mass spectrometric analysis to determine the gaseous species evolved, with complementary data on phase changes and thermal decomposition reactions obtained from differential thermal analysis (DTA) or scanning calorimetry (DSC) techniques. NH 3 is typically evolved from precursors such as melamine and DCDA above approximately 450 1C, with C 2 N 2 and volatile C x N y H z species, not all of which have been identified, appearing in the gas phase at higher temperatures (480-540 1C).…”

Section: Compositional Analysismentioning

confidence: 99%

Carbon nitrides: synthesis and characterization of a new class of functional materials

Miller

Sobrido

Suter

et al. 2017

Phys. Chem. Chem. Phys.

387

351

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“…With a quantity of approximately 100 fold less consumed per sample compared to the titration, the microanalysis technique takes a major place in discovery activities (Paul 2015;Fadeeva et al 2008), where synthesized compounds are delivered in a range of 1 to 100 mg per batch.…”

Section: Microanalysis Capabilities-experimental and Theoretical Centmentioning

confidence: 99%

Mat-CHN software for drug substance titrations in discovery and development

Vidaud¹

2018

J Anal Sci Technol

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Background: Elemental Analysis (microanalysis) is a reference method widely used to make assessments of thequality of chemical or biochemical substances. Using very small quantities of substance and no methoddevelopment, this analytical technique delivers absolute assays. Compared to other methods needing larger samplequantities and most of the time reference standards, the Elemental Analysis is the preferred technique of scientists. Methods: One of the difficulties with this method is the definition of the theoretical elemental composition when several complementary assays values, generally delivered in w/w percentages (e.g., water content by Karl Fischer method), instead of mole numbers (as this is the case for NMR determination), must be taken into account. The situation is manageable with only one of this type of additional assay; however, this exercise becomes more complicated when the scientists must integrate two or more assay values. Mat-CHN software was developed specifically to resolve these difficulties, by delivering the individual mole numberof each constituent assayed in the compound analyzed, leading to an accurate comparison of the theoretical and experimental results of centesimal compositions. Results: Apart its large capabilities for simulations, Mat-CHN increases the interest of the Elemental Analysis technique for scientists working in discovery fields or when new molecular entities are promoted to predevelopment and development stages, either for absolute titration of their reference standards or for direct titrations of the drug substance itself. The software conducts to simple titration determinations, based on Nitrogen "Kjeldhal" assays and/or molecular weight reports, compared to data of the pure substance.

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Elemental analysis of organic compounds with the use of automated CHNS analyzers

Cited by 173 publications

References 18 publications

Organoclay-modified electrodes: preparation, characterization and recent electroanalytical applications

Organoclay-modified electrodes: preparation, characterization and recent electroanalytical applications

Carbon nitrides: synthesis and characterization of a new class of functional materials

Mat-CHN software for drug substance titrations in discovery and development

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