Medicinal plants can amass chemical elements in their tissues due to their ability to tolerate potentially toxic ions in the environment. The Hypericum perforatum L. plants were cultivated in three regions of West Siberia (Kemerovo, Novosibirsk, Kam lak Village (Altai Republic)). Elemental analysis was conducted by atomic emission spectrometry. Chemical elements extractable with 10% HCl were assayed by atomic absorption spectrometry. The concentrations of Co, Ni, Cu and Zn have been relatively stable. The coefficients of biogeochemical mobility of Cd, Cu and Zn had high rates, which confirm the possibility of accumulation of these elements in H. perforatum. The concentration of chemical elements in extracts (10 % HCl) was increased as well as their total contents, the degree of extraction was highest for K, Ni, Fe, Cu, Mn, Mg (90 % or more), the minimum for Na (20–40 %) and significantly changed in environmentally different habitats.