Elemental fragmentation cross sections for a 16O beam of 400 MeV/u kinetic energy interacting with a graphite target using the FOOT ΔE-TOF detectors

Toppi, M.; Sarti, A.; Alexandrov, A.; Alpat, B.; Ambrosi, G.; Argirò, S.; Díaz, Raúl Arteche; Barbanera, M.; Bartosik, Nazar; Battistoni, G.; Belcari, Nicola; Biondi, S.; Bisogni, Maria Giuseppina; Bon, M.; Bruni, G.; Carra, P.; Cavanna, F.; Cerello, P.; Ciarrocchi, Esther; Clozza, A.; Colombi, S.; Lellis, G. De; Gregorio, Angelica De; Guerra, Alberto Del; Simoni, Micol De; Crescenzo, A. Di; Ruzza, B. Di; Donetti, M.; Dong, Yunsheng; Durante, Marco; Ferrero, Veronica; Fiandrini, E.; Finck, C.; Fiorina, Elisa; Fischetti, M.; Francesconi, M.; Franchini, M.; Franciosini, G.; Galati, G.; Galli, L.; Giraudo, G.; Hetzel, R.; Iarocci, E.; Ionica, M.; Iuliano, A.; Kanxheri, K.; Kraan, A.; Tessa, Chiara La; Martina, L.; Lauria, A.; Torres, E. López; Marafini, M.; Massa, M.; Massimi, C.; Mattei, I.; Meneghetti, A.; Mengarelli, A.; Mirabelli, R.; Moggi, A.; Montesi, M.C.; Morone, M. C.; Morrocchi, M.; Muraro, S.; Murtas, F.; Muscato, Annalisa; Pastore, A.; Pastrone, N.; Patera, V.; Pennazio, Francesco; Peverini, Francesca; Placidi, P.; Pullia, M.; Ramello, L.; Reidel, Claire-Anne; Ridolfi, R.; Rosso, V.; Sanelli, C.; Sartorelli, G.; Sato, Osamu; Savazzi, S.; Scavarda, L.; Schiavi, A.; Schuy, Christoph; Scifoni, E.; Sciubba, A.; Sécher, Alexandre; Selvi, M.; Servoli, L.; Silvestre, G.; Sitta, M.; Spighi, R.; Spiriti, E.; Sportelli, Giancarlo; Stahl, A.; Tomassini, S.; Tommasino, Francesco; Tioukov, V.; Traini, G.; Trigilio, Antonio; Valle, S.M.; Vanstalle, M.; Weber, Ulrich; Zarrella, R.; Zoccoli, À.; Villa, M.

doi:10.3389/fphy.2022.979229

Cited by 5 publications

(3 citation statements)

References 37 publications

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“…All of the above contributes also to the observed differences between primary and secondary fluence, which were obtained by applying similar cuts in experiment and in simulation. Nevertheless, considering the uncertain modelling of nuclear fragmentation in Monte Carlo for carbon ions [30,31], the agreement between simulation and experiment was deemed satisfactory for the presented analysis.…”

Section: Discussionmentioning

confidence: 84%

Investigating Slit-Collimator-Produced Carbon Ion Minibeams with High-Resolution CMOS Sensors

et al. 2023

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Particle minibeam therapy has demonstrated the potential for better healthy tissue sparing due to spatial fractionation of the delivered dose. Especially for heavy ions, the spatial fractionation could enhance the already favorable differential biological effectiveness at the target and the entrance region. Moreover, spatial fractionation could even be a viable option for bringing ions heavier than carbon back into patient application. To understand the effect of minibeam therapy, however, requires careful conduction of pre-clinical experiments, for which precise knowledge of the minibeam characteristics is crucial. This work introduces the use of high-spatial-resolution CMOS sensors to characterize collimator-produced carbon ion minibeams in terms of lateral fluence distribution, secondary fragments, track-averaged linear energy transfer distribution, and collimator alignment. Additional simulations were performed to further analyze the parameter space of the carbon ion minibeams in terms of beam characteristics, collimator positioning, and collimator manufacturing accuracy. Finally, a new concept for reducing the neutron dose to the patient by means of an additional neutron shield added to the collimator setup is proposed and validated in simulation. The carbon ion minibeam collimator characterized in this work is used in ongoing pre-clinical experiments on heavy ion minibeam therapy at the GSI.

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Section: Discussionmentioning

confidence: 84%

Investigating Slit-Collimator-Produced Carbon Ion Minibeams with High-Resolution CMOS Sensors

et al. 2023

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“…Figure 4 shows the preliminary total and angular cross-section measurements [5] of 400 MeV/u 16 O beam impinging on a 5 mm C target. Since the contributions due to uncertainties and systematic are under investigation, the distributions are normalized in order to emphasize their shape, leaving the final cross-section values for a dedicated paper.…”

Section: Preliminary Resultsmentioning

confidence: 99%

Nuclear Fragmentation Cross-Section Measurements with the FOOT Experiment

Ubaldi

2024

Acta Phys. Pol. A

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The main goals of the FragmentatiOn Of Target experiment are the measurements of double-differential fragmentation cross-sections of light particles (Z < 10) in the energy range between 100-800 MeV/u, which is of interest for hadron therapy and space radioprotection applications. The results will fill the gap in experimental data in this range, which is important for improving the treatment planning systems in particle therapy and for enhancing the reliability of risk-assessment models for space radioprotection. Two different setups were designed for this scope, and data have already been taken in several campaigns. In this paper, an overview of the apparatus is described, focusing on the preliminary results of crosssection measurements obtained with a 16 O beam at the GSI facility. topics: FOOT (FragmentatiOn Of Target), nuclear fragmentations, cross sections measurements

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“…Finally, it is worth noting that current evaluations of fragmentation cross sections exhibit uncertainties exceeding 10%, which must be tightened in order to accurately model positron fragmentation, particularly in the case of complex fragmentation reactions such as the production of 10 C (Bolst et al 2017, Toppi et al 2022. These uncertainties are especially due to the effective cross-sections that are double-differential in angle and energy.…”

Section: Overall Recommendationmentioning

confidence: 99%

A quantitative assessment of Geant4 for predicting the yield and distribution of positron-emitting fragments in ion beam therapy

Chacon,

Rutherford,

Hamato

et al. 2024

Phys. Med. Biol.

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Purpose: To compare the accuracy with which different hadronic inelastic physics models across ten Geant4 Monte Carlo simulation toolkit versions can predict positron-emitting fragments produced along the beam path during carbon and oxygen ion therapy.Materials and Methods: Phantoms of polyethylene, gelatin or poly(methyl methacrylate) were irradiated with monoenergetic carbon and oxygen ion beams. Post-irradiation, 4D PET images were acquired and parent 11C, 10C and 15O radionuclides contributions in each voxel were determined from the extracted time activity curves. Next, the experimental configurations were simulated in Geant4 Monte Carlo versions 10.0 to 11.1, with three different fragmentation models - binary ion cascade (BIC), quantum molecular dynamics (QMD) and the Liege intranuclear cascade (INCL++) - 30 model-version combinations. Total positron annihilation and parent isotope production yields predicted by each simulation were compared between simulations and experiments using normalised mean squared error and Pearson cross-correlation coefficient. Finally, we compared the depth of maximum positron annihilation yield and the distal point at which positron yield decreases to 50% of peak between each model and the experimental results.Results: Performance varied considerably across versions and models, with no one version/model combination providing the best prediction of all positron-emitting fragments in all evaluated target materials and irradiation conidiations. BIC in Geant4 10.2 provided the best overall agreement with experimental results in the largest number of test cases. QMD consistently provided the best estimates of both the depth of peak positron yield (10.4 and 10.6) and the distal 50%-of-peak point (10.2), while BIC also performed well and INCL generally performed the worst across most Geant4 versions.Conclusions: Best spatial prediction of annihilation yield and positron-emitting fragment production during carbon and oxygen ion therapy was found to be 10.2.p03 with BIC or QMD. These version/model combinations are recommended for future heavy ion therapy research.

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Elemental fragmentation cross sections for a 16O beam of 400 MeV/u kinetic energy interacting with a graphite target using the FOOT ΔE-TOF detectors

Cited by 5 publications

References 37 publications

Investigating Slit-Collimator-Produced Carbon Ion Minibeams with High-Resolution CMOS Sensors

Investigating Slit-Collimator-Produced Carbon Ion Minibeams with High-Resolution CMOS Sensors

Nuclear Fragmentation Cross-Section Measurements with the FOOT Experiment

A quantitative assessment of Geant4 for predicting the yield and distribution of positron-emitting fragments in ion beam therapy

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