Elemental imaging of rat epididymis by micro-PIXE analysis

Homma-Takeda, Shino; Nishimura, Y.; Watanabe, Yoshito; Imaseki, Hitoshi; Yukawa, Masae

doi:10.1016/s0168-583x(03)01064-4

Cited by 15 publications

(3 citation statements)

References 15 publications

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“…Microbeam-based elemental analyses, such as particle-induced X-ray emission (PIXE) and synchrotron radiation X-ray fluorescence (SR-XRF), are valuable for obtaining elemental profiles of small areas and the precise distributions of elements in tissues [6][7][8]. High-energy incident X-rays in SR-XRF are suitable for detecting small amounts of uranium in tissues because they excite uranium L-lines that do not interfere with major elements such as calcium and potassium, unlike uranium M-lines.…”

Section: Introductionmentioning

confidence: 99%

Elemental imaging of kidneys of adult rats exposed to uranium acetate

Homma-Takeda¹,

Terada

Nakata³

et al. 2009

Nuclear Instruments and Methods in Physics Research Section B:

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Section: Introductionmentioning

confidence: 99%

Elemental imaging of kidneys of adult rats exposed to uranium acetate

Homma-Takeda¹,

Terada

Nakata³

et al. 2009

Nuclear Instruments and Methods in Physics Research Section B:

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“…Ion PIXE provides multi-elemental capability, which allows the simultaneous comparison of distribution of several elements inside the same specimen [401][402][403][404][405][406][407][408][409][410].…”

Section: Ion Beam Analysis Techniquesmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville³

2016

Nano Online

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The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in synthesis protocol and characterization of these materials whereas toxicological issues are sometimes incomplete. Nanoparticle-based contrast agents tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of 2 imaging modalities. Multimodal nanoparticles (NPs) are much more efficient than conventional molecular-scale contrast agents. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides specific applications for classical imaging, (MRI, PET, CT, US, PAI) are also mentioned less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA).Perspectives on multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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“…Micro PIXE analysis allows determination of such a precise distribution of elements in microorganisms 6 and insects 7 as well as in animal tissues. [8][9][10] In the present study, we examined the distributions of elements in cross sections of S. marmorata exposed to mercuric chloride.…”

Section: Introductionmentioning

confidence: 99%

MERCURY DISTRIBUTION BY MICRO PIXE ANALYSIS IN STENOPSYCHE MARMORATA EXPOSED TO MERCURIC CHLORIDE

Yoshitomi

Yaginuma

Iso³

et al. 2008

Int. J. PIXE

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Aquatic insects, such as caddisflies, are used as reference organisms for water pollution. The precise distribution of contaminated metals in the insect, however, remains unknown. In this study, we used micro PIXE analysis to examine mercury distribution in Stenopsyche marmorata, a typical caddisfly, exposed to mercuric chloride. The mercury level in the caddisflies after exposure to mercuric chloride at 1 mg/L for 5 days was 93.3 ± 25.0 µg/g wet weight. Micro PIXE analysis also revealed a site-specific distribution of mercury in the insects. Mercury was high in the digestive tract, where it was localized in the basement membrane and the peritrophic membrane. Mercury was also detected in the tissue surrounding the digestive tract. Further examination of the tissue identified mercury in the fat body but not in the silk gland.

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Elemental imaging of rat epididymis by micro-PIXE analysis

Cited by 15 publications

References 15 publications

Elemental imaging of kidneys of adult rats exposed to uranium acetate

Elemental imaging of kidneys of adult rats exposed to uranium acetate

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

MERCURY DISTRIBUTION BY MICRO PIXE ANALYSIS IN STENOPSYCHE MARMORATA EXPOSED TO MERCURIC CHLORIDE

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