“…7, we describe the algebra of second-order differential operators associated with the weight matrix W (α,β,v) given in (2.4) and (2.5). Indeed, for a given weight matrix W , the analysis of the algebra D(W ) of all differential operators that have a sequence of matrix-valued orthogonal polynomials with respect to W as eigenfunctions has received much attention in the literature in the last fifteen years [6,8,9,33,42,45,47]. While for classical orthogonal polynomials, the structure of this algebra is very well-known (see [39]), in the matrix setting, where this algebra is non-commutative, the situation is highly non-trivial.…”