Affordable, reliable endo-and exoatmospheric transportation, for both the military and commercial sectors, grows in importance as the world grows smaller and space exploration and exploitation increasingly impact our daily lives. However, the impact of disciplinary, operational, and technological uncertainties inhibit the design of the requisite hypersonic vehicles, an inherently multidisciplinary and non-deterministic process. Without investigation, these components of design uncertainty undermine the designers' decision-making confidence.