Elemicin exposure induced aberrant lipid metabolism via modulation of gut microbiota in mice

Zhang, Yi; Ji, Mufan; Gu, Zhenyang; Pei, Wenlong; Zhu, Jun; Wu, Qian; Li, Lei; Zhang, Zhan

doi:10.1016/j.tox.2021.153088

Cited by 10 publications

(9 citation statements)

References 35 publications

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“…Previous studies have confirmed that essential oils can improve immunity and reduce morbidity by promoting immune organ development, stimulating immune cell production, increasing the conversion rate of lymphocytes and increasing immunoglobulin levels 21 . Most studies have shown that the addition of essential oils to the feed could improve the immunity of mice 28 . This is consistent with our findings showing that feeding diets containing orange essential oil improved the immune organ index of mice more significantly.…”

Section: Resultssupporting

confidence: 92%

“…21 Most studies have shown that the addition of essential oils to the feed could improve the immunity of mice. 28 This is consistent with our findings showing that feeding diets containing orange essential oil improved the immune organ index of mice more significantly. This indicated that the addition of orange essential oil at low concentrations to the feed could affect the immune organ index of mice and improve their immunity.…”

Section: Effect Of Orange Essential Oil With Respect To Different Ing...supporting

confidence: 93%

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Effect of different ways of ingesting orange essential oil on blood immune index and intestinal microflora in mice

Zhang

Ren

et al. 2022

J Sci Food Agric

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BACKGROUND Studies have found that the addition of plant essential oils to feed had a positive effect on intestinal microflora and immunity in mice. However, the effect of different ways of ingestion of orange essential oil on mice has seldom been reported. In the present study, we investigated the effects of ingestion of orange essential oil by gavage, sniffing and feeding on intestinal microflora and immunity in mice. RESULTS The results obtained showed that a low concentration of essential oil feeding significantly increased the spleen index of mice (P < 0.05). The effect of different ways of ingestion on the thymus index, immunoglobulin G and immunoglobulin M of mice was not significant (P > 0.05). High and medium concentrations of essential oil feeding increased the level of interleukin‐2 in mice (P < 0.05). H+K+‐ATPase activity was significantly increased in mice fed with gavage and different concentrations of essential oil feed compared to the control group (P < 0.05). The analysis of the results of the microflora in the cecum and colon of mice indicated that the medium concentration of essential oil feeding group and the sniffing group significantly changed the structure of the flora and increased the diversity of the intestinal microflora. All three essential oil ingestion methods increased the abundance of Bacteroidetes and Lactobacillus in the intestine of mice. CONCLUSION Compared with gavage and feeding, sniffing had a significant effect on immunoglobulins in mice. All the three ingestion methods could affect the intestinal microflora of mice and increase the abundance of Lactobacillus. © 2022 Society of Chemical Industry.

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Section: Resultssupporting

confidence: 92%

Section: Effect Of Orange Essential Oil With Respect To Different Ing...supporting

confidence: 93%

Effect of different ways of ingesting orange essential oil on blood immune index and intestinal microflora in mice

Zhang

Ren

et al. 2022

J Sci Food Agric

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“…The LEfSe analysis also displayed that GA increased the abundance of Anaerostipes and Butyricicoccus, which can promote butyric acid production, reverse bacterial imbalance caused by a high-fat diet, improve inflammation, and protect the intestinal mucosal barrier . Stevioside increased the abundance of Gordonibacter, which is a potentially harmful bacterium positively correlated with TG and glutamic-pyruvate transaminase and whose level was high in mice with abnormal lipid metabolism and cholestatic liver injury. , Erythritol enriched Eubacterium_xylanophilum_group that can produce SCFAs and reduce liver inflammation, and enriched Anaeroplasma that can be used to treat chronic intestinal inflammation and has been shown to increase in mice with the improvement of T2DM symptoms by polysaccharides . Sucralose increased Parasutterella, whose abundance was high in T2DM patients and patients or mice with irritable bowel syndrome. , Additionally, Streptococcus increased after aspartame exposure, which is also detrimental to the body’s blood glucose and blood lipid regulation. , …”

Section: Discussionmentioning

confidence: 94%

Natural Sweetener Glycyrrhetinic Acid Monoglucuronide Improves Glucose Homeostasis in Healthy Mice

Wang,

Guo,

Zheng

et al. 2024

J. Agric. Food Chem.

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Noncaloric or low-caloric sweeteners have become popular worldwide, although debates persist regarding their impact on health. To investigate whether the sweeteners are favorable for glucose homeostasis, our study assessed the effects of glycyrrhetinic acid monoglucuronide (GAMG) and several commonly used sweeteners [glycyrrhetinic acid (GA), stevioside, erythritol, sucralose, and aspartame] on glycometabolism and elucidated the underlying mechanisms. The C57BL/6J male mice were exposed to different sweeteners for 10 weeks, and our results showed that GAMG significantly reduced fasting blood glucose (FBG) levels (FBG-control: 3.81 ± 0.42 mmol/L; FBG-GAMG: 3.37 ± 0.38 mmol/L; p < 0.05) and the blood glucose levels 15 and 30 min after sucrose or maltose loading (p < 0.05). Furthermore, it improved glucose tolerance (p = 0.028) and enhanced insulin sensitivity (p = 0.044), while the other sweeteners had negligible or adverse effects on glucose homeostasis. Subsequent experiments showed that GAMG inhibited α-glucosidases potently (IC 50 = 0.879 mg•mL −1 ), increased three SCFA-producing bacteria and SCFAs levels (p < 0.05), and promoted the gene expression of SCFA receptor GPR43 (p = 0.018). These results suggest that GAMG may regulate blood glucose by inhibiting α-glucosidases and modulating gut microbial SCFAs. Our findings prove that GAMG, beneficial to blood glucose regulation, is a promising natural sweetener for future utilization.

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“…Previous investigations showed that DON triggers microbiota dysbiosis, which is mainly manifested by reducing the abundance of Actinobacteria and Bacteroidetes , and changing the abundance of microbes at the family and genus levels. , In line with these findings, we found that DON alters bacterial community structure in mice, and significantly increased the abundance of Gordonibacter , Ruminiclostridium_6 , and Ruminococcaceae_UCG-010 . Gordonibacter and Ruminococcaceae_UCG-010 have been found to be more abundant in different diseases. , Specifically, Ruminiclostridium_6 is significantly positively correlated with pro-inflammatory cytokines, such as IL-6 and TNF-α . However, these harmful bacteria were not observed in the LGG + DON group.…”

Section: Discussionmentioning

confidence: 97%

“…Gordonibacter and Ruminococcaceae_UCG-010 have been found to be more abundant in different diseases. 60,61 Specifically, Rumini-clostridium_6 is significantly positively correlated with proinflammatory cytokines, such as IL-6 and TNF-α. 62 However, these harmful bacteria were not observed in the LGG + DON group.…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiota Mediates Lactobacillus rhamnosus GG Alleviation of Deoxynivalenol-Induced Anorexia

Bai

Meng

Wang

et al. 2023

J. Agric. Food Chem.

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Deoxynivalenol (DON) is a widespread mycotoxin and causes anorexia and emesis in humans and animals; Lactobacillus rhamnosus GG (LGG), a well-characterized probiotic, can improve intestinal barrier function and modulate immune response. Currently, it is unclear whether LGG has a beneficial effect on DON-induced anorexia. In the present study, mice were treated with DON, LGG, or both by gavage for 28 days to evaluate the effects of LGG on DON-induced anorexia. Antibiotic treatment and fecal microbiota transplant (FMT) experiment were also conducted to investigate the link between DON, LGG, and gut microbiota. LGG significantly increased the villus height and reduced the crypt depth in jejunum and ileum, enhanced the tight junction proteins expression in the intestine, and regulated the TLR4/NF-κB signaling pathway, consequently attenuating the intestinal inflammation caused by DON. In addition, LGG increased the relative abundance of Lactobacillus and butyric acid production of cecal contents; remodeled phenylalanine metabolism and tryptophan metabolism; reduced plasma peptide tyrosine tyrosine (PYY), 5-hydroxytryptamine (5-HT), and glucagon-like peptide-1 (GLP-1) concentrations; and promoted hypothalamic NPY and AgPR gene expression, which will further promote food intake and reduce weight loss, ultimately alleviating DON-induced anorexia in mice. Interestingly, antibiotic treatment diminished the intestinal toxicity of DON. The FMT experiment showed that DON-originated microbiota promotes intestinal inflammation and anorexia, while LGG + DON-originated microbiota has no adverse effects on mice. Both antibiotic treatment and FMT experiment have proved that gut microbiota was the primary vector for DON to exert its toxic effects and an essential mediator of LGG protection. In summary, our findings demonstrate that gut microbiota plays essential roles in DON-induced anorexia, and LGG can reduce the adverse effects caused by DON through its structure and regulate the gut microbiota, which may lay the important scientific foundation for future applications of LGG in food and feed products.

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Elemicin exposure induced aberrant lipid metabolism via modulation of gut microbiota in mice

Cited by 10 publications

References 35 publications

Effect of different ways of ingesting orange essential oil on blood immune index and intestinal microflora in mice

Effect of different ways of ingesting orange essential oil on blood immune index and intestinal microflora in mice

Natural Sweetener Glycyrrhetinic Acid Monoglucuronide Improves Glucose Homeostasis in Healthy Mice

Gut Microbiota Mediates Lactobacillus rhamnosus GG Alleviation of Deoxynivalenol-Induced Anorexia

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