Eleutheroside <scp>E</scp> reduces intestinal fat accumulation in <i>Caenorhabditis elegans</i> through neuroendocrine signals

Liu, Mengyao; Gao, Xin; Shan, Shan; Li, Yongzhi; Wang, Jiaping; Lu, Weihong

doi:10.1002/jsfa.11875

Cited by 4 publications

(2 citation statements)

References 42 publications

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“…Thereafter, endocrine signals induce the hydrolysis of ATGL-1 and fatty acid β-oxidation in the intestine. By using neuroendocrine-related mutants and tissue-specific rescue methods, Eleutheroside E can reduce the intestinal lipid accumulation through serotonin and neuropeptide flp-7-npr-22 pathways in C. elegans [ 82 ].…”

Section: Conserved Fat Metabolism Signaling Pathways In C E...mentioning

confidence: 99%

Application of Caenorhabditis elegans in Lipid Metabolism Research

Chen

et al. 2023

IJMS

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Over the last decade, the development and prevalence of obesity have posed a serious public health risk, which has prompted studies on the regulation of adiposity. With the ease of genetic manipulation, the diversity of the methods for characterizing body fat levels, and the observability of feeding behavior, Caenorhabditis elegans (C. elegans) is considered an excellent model for exploring energy homeostasis and the regulation of the cellular fat storage. In addition, the homology with mammals in the genes related to the lipid metabolism allows many aspects of lipid modulation by the regulators of the central nervous system to be conserved in this ideal model organism. In recent years, as the complex network of genes that maintain an energy balance has been gradually expanded and refined, the regulatory mechanisms of lipid storage have become clearer. Furthermore, the development of methods and devices to assess the lipid levels has become a powerful tool for studies in lipid droplet biology and the regulation of the nematode lipid metabolism. Herein, based on the rapid progress of C. elegans lipid metabolism-related studies, this review outlined the lipid metabolic processes, the major signaling pathways of fat storage regulation, and the primary experimental methods to assess the lipid content in nematodes. Therefore, this model system holds great promise for facilitating the understanding, management, and therapies of human obesity and other metabolism-related diseases.

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Section: Conserved Fat Metabolism Signaling Pathways In C E...mentioning

confidence: 99%

Application of Caenorhabditis elegans in Lipid Metabolism Research

Chen

et al. 2023

IJMS

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“…Liu et al have used C. elegans to estimate the ability of eleutheroside E to reduce intestinal fat accumulation in the intestine . However, the structure of C.…”

Section: Introductionmentioning

confidence: 99%

Intestinal Barrier Protective Study of Jujube Peel Polyphenols/Zein Complexes by a Combined Caco-2 Cell and Caenorhabditis elegans Model: A Perspective of Proteomics

Zhu

Dou

et al. 2023

J. Agric. Food Chem.

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Jujube peels have been recognized as a promising resource of several bioactive ingredients. The main composition of jujube peel polyphenols (JPP) has been identified as rutin, kaempferol-3-O-rutinosid, and salicylic acid. The JPP/zein complexes, whose bioavailability reached 69.73% ± 5.06% in vitro, have been formed successfully. The Caco-2 cell and Caenorhabditis elegans (C. elegans) models have been combined to detect the intestinal barrier protective effect of JPP and its complexes. Results showed that JPP/zein complexes contain better protection capability than JPP in both models. In the Caco-2 cell model, the complex relieved intestinal barrier damage by regulating the tight junction proteins. Moreover, the lysosome pathway has been activated, further regulating immune responses and lipid transportation, improving the barrier function of C. elegans after incubation with JPP/zein complexes according to the proteomics study. This work provides new insights into intestinal barrier protection with bioactive compounds.

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Optimization of the Extraction Process of Effective Components of Eleutherococcus senticosus Using Mathematical Models

Zhang,

Wang,

Liu

et al. 2024

Journal of Food Quality

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Eleutheroside B, eleutheroside E, and isofraxidin are all important active ingredients for medicinal purposes of Eleutherococcus senticosus (Rupr. and Maxim).To improve the efficacy and quality of Chinese medicinal materials, optimizing the extraction process is necessary. By improving and innovating the process, the utilization efficiency of medicinal materials can be enhanced, promoting the effective utilization of Chinese medicinal materials. This experiment focused on three traditional components of Eleutherococcus senticosus, a medicinal plant known for its various bioactive properties. High‐performance liquid chromatography and response surface methodology were employed to investigate the effects of extraction parameters on the yield of these components. Mathematical model analysis was used to optimise the response surface experimental design and to determine the exact extraction conditions for each ingredient. In the extraction method prediction model, the method described in the best group extracted more of the three active ingredients. The extraction rate of the components was increased by 1.33 percent compared to the conventional extraction method. Meanwhile, the R‐square of this prediction model was as high as 0.938. A validated method was used to quantify the three components in 21 samples of Eleutherococcus senticosus from different origins. The results revealed significant variations in the component content among the samples. The recall F1 of cross‐validation sets in the GA‐decision tree of the classifier reaches 0.833. K‐means cluster analysis was performed to classify the samples based on their component profile, providing a basis for quality assessment. The novel content evaluation model developed in this study enabled a reliable and visual comparison of the component differences among the samples and extraction conditions, determining the optimal extraction parameters for each component of Eleutherococcus senticosus. This study offers new techniques and insights for the development and utilization of natural active ingredients from Chinese herbs, with important scientific and practical implications.

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Eleutheroside E reduces intestinal fat accumulation in Caenorhabditis elegans through neuroendocrine signals

Cited by 4 publications

References 42 publications

Application of Caenorhabditis elegans in Lipid Metabolism Research

Application of Caenorhabditis elegans in Lipid Metabolism Research

Intestinal Barrier Protective Study of Jujube Peel Polyphenols/Zein Complexes by a Combined Caco-2 Cell and Caenorhabditis elegans Model: A Perspective of Proteomics

Optimization of the Extraction Process of Effective Components of Eleutherococcus senticosus Using Mathematical Models

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