Elevated adenosine deaminase activity in overweightand obese Indian subjects

Jadhav, Ashish Anantrao; Jain, Ashu

doi:10.3109/13813455.2011.603341

Cited by 20 publications

(10 citation statements)

References 48 publications

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“…28 In another study showed that serum adenosine deaminase, an endogenous anti-inflammatory metabolite, is elevated in response to inflammatory status resulted by adipose tissue in obesity. 29 Serum adenosine deaminase levels have been found to be increased in patients with Inflammatory bowel disease, and serum adenosine deaminase is a useful biomarker for assessment of intestinal inflammation. 30 It is well established in the literature that a significantly correlation between serum adenosine deaminase and C-reactive protein has been suggested in patients with chagas disease, 31 supporting the view, our data also showed the link between serum adenosine deaminase and high-sensitivity C-reactive protein in T2DM patients.…”

Section: Discussionmentioning

confidence: 99%

Serum Adenosine Deaminase as a Useful Marker to Estimate Coronary Artery Calcification in Type 2 Diabetes Mellitus Patients

Zhou

et al. 2021

Clin Appl Thromb Hemost

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We investigated the association between serum adenosine deaminase and coronary artery calcification (CAC) in type 2 diabetes mellitus (T2DM) patients. The cross-sectional study included 459 patients with T2DM, the clinical and laboratory tests were performed, and all T2DM patients were separated into the 3 groups based on the tertile of serum adenosine deaminase levels. In the baseline data, the CAC score had statistically significant differences between the 3 groups (p < 0.001). Serum adenosine deaminase levels were positively correlated with CAC score in T2DM patients (r = 0.355, p < 0.001). The results of multiple linear regression analysis showed that serum adenosine deaminase was independent positively correlated with CAC score in T2DM patients (r = 0.255, p < 0.001). Receiver-operating characteristic curve analysis showed that area under curve was 0.750 to identify T2DM patients with CAC. Serum adenosine deaminase levels are correlated with CAC scores in T2DM patients, clinically, serum adenosine deaminase should be considered as an underlying marker to determine the severity of atherosclerosis in T2DM patients.

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Section: Discussionmentioning

confidence: 99%

Serum Adenosine Deaminase as a Useful Marker to Estimate Coronary Artery Calcification in Type 2 Diabetes Mellitus Patients

Zhou

et al. 2021

Clin Appl Thromb Hemost

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“…Synovial ADA fluid measurement, in association with CRP and ESR levels, can distinguish OA from other rheumatic diseases, like RA ( 186 ). There is a study in the Indian population that links increased ADA activity with being overweight and obesity ( 150 ). This link should be studied in obese patients with OA to understand better the role of ADA as an adenosine level regulator.…”

Section: Discussionmentioning

confidence: 99%

Purinergic System Signaling in Metainflammation-Associated Osteoarthritis

et al. 2020

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Inflammation triggered by metabolic imbalance, also called metainflammation, is low-grade inflammation caused by the components involved in metabolic syndrome (MetS), including central obesity and impaired glucose tolerance. This phenomenon is mainly due to excess nutrients and energy, and it contributes to the pathogenesis of osteoarthritis (OA). OA is characterized by the progressive degeneration of articular cartilage, which suffers erosion and progressively becomes thinner. Purinergic signaling is involved in several physiological and pathological processes, such as cell proliferation in development and tissue regeneration, neurotransmission and inflammation. Adenosine and ATP receptors, and other members of the signaling pathway, such as AMP-activated protein kinase (AMPK), are involved in obesity, type 2 diabetes (T2D) and OA progression. In this review, we focus on purinergic regulation in osteoarthritic cartilage and how different components of MetS, such as obesity and T2D, modulate the purinergic system in OA. In that regard, we describe the critical role in this disease of receptors, such as adenosine A2A receptor (A2AR) and ATP P2X7 receptor. Finally, we also assess how nucleotides regulate the inflammasome in OA.

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“…Its vasoactivity with the association of intracellular energetic metabolism and other actions, including inhibition of platelet aggregation, sympathetic neurotransmission, lipolysis and stimulation of glucose transport and oxidation, indicate that physiological role of adenosine is to inhibit energy consumption in some tissues and increase energy supplies in others [ 25 , 27 ]. During inflammatory condition which happens in obesity and type 2 diabetes, adenosine is released in order to decrease the production of cytokines [ 28 , 29 ]. It was reported that sensitivity of several tissues to adenosine, including kidney, may increase as a result of insulin-dependent diabetes.…”

Section: Discussionmentioning

confidence: 99%

Effect of decaffeinated coffee on function and nucleotide metabolism in kidney

et al. 2017

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Little is known about the effects of coffee that are not related to the presence of caffeine. The aim of the study was to analyse changes in kidney function and nucleotide metabolism related to high intake of decaffeinated coffee. Mice consumed decaffeinated coffee extract for two weeks. Activities of AMP deaminase, ecto5′-nucleotidase, adenosine deaminase, purine nucleoside phosphorylase were measured in kidney cortex and medulla by analysis of conversion of substrates into products using HPLC. Concentration of nucleotides in kidney cortex, kidney medulla and serum were estimated by HPLC. Activity of ecto5′-nucleotidase increased from 0.032 ± 0.006 to 0.049 ± 0.014 nmol/mg tissue/min in kidney cortex of mice administered high-dose decaffeinated coffee (HDC) together with increase in cortex adenosine concentration and decrease in plasma creatinine concentration. HDC leads to increased activity of ecto5′-nucleotidase in kidney cortex that translates to increase in concentration of adenosine. Surprisingly this caused improved kidney excretion function.

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Elevated adenosine deaminase activity in overweightand obese Indian subjects

Cited by 20 publications

References 48 publications

Serum Adenosine Deaminase as a Useful Marker to Estimate Coronary Artery Calcification in Type 2 Diabetes Mellitus Patients

Serum Adenosine Deaminase as a Useful Marker to Estimate Coronary Artery Calcification in Type 2 Diabetes Mellitus Patients

Purinergic System Signaling in Metainflammation-Associated Osteoarthritis

Effect of decaffeinated coffee on function and nucleotide metabolism in kidney

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