Elevated adiabatic T1ρ and T2ρ in articular cartilage are associated with cartilage and bone lesions in early osteoarthritis: A preliminary study

Casula, Victor; Nissi, Mikko J.; Podlipská, Jana; Haapea, Marianne; Koski, Juhani M.; Saarakkala, Simo; Guermazi, Ali; Lammentausta, Eveliina; Nieminen, Miika T.

doi:10.1002/jmri.25616

Cited by 26 publications

(31 citation statements)

References 40 publications

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“…Recent studies have shown that AdiabT 1ρ is sensitive to both ex vivo enzymatic cartilage degradation and in vivo articular cartilage degradation in OA patients . More importantly, the AdiabT 1ρ is much less sensitive to the magic angle effect than both conventional CW‐T 1ρ and T 2 as demonstrated in previous bovine cartilage studies .…”

Section: Discussionmentioning

confidence: 82%

3D adiabatic T_1ρ prepared ultrashort echo time cones sequence for whole knee imaging

Carl²,

Searleman

et al. 2018

Magnetic Resonance in Med

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Section: Discussionmentioning

confidence: 82%

3D adiabatic T_1ρ prepared ultrashort echo time cones sequence for whole knee imaging

Carl²,

Searleman

et al. 2018

Magnetic Resonance in Med

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“…For example, fibrillation of the cartilage surface that was not visible by eye could be observed using optical coherence tomography, and alterations in mechanical properties were discovered using atomic force microscopy (AFM) [7][8][9][10]. Additionally, loss of glycosaminoglycan (GAG) content and water retention could be detected by AFM or magnetic resonance imaging and Fourier transformed infrared imaging [11][12][13]. Quantitative polarized light microscopy has been employed to visualize collagen, taking advantage of collagen's birefringence [7,[14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Bioluminescence and second harmonic generation imaging reveal dynamic changes in the inflammatory and collagen landscape in early osteoarthritis

Mingalone¹,

Liu²,

Hollander³

et al. 2018

Laboratory Investigation

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Osteoarthritis (OA) is a leading cause of chronic disability whose mechanism of pathogenesis is largely elusive. Local inflammation is thought to play a key role in OA progression, especially in injury-associated OA. While multiple inflammatory cytokines are detected, the timing and extent of overall inflammatory activities in early OA and the manner by which joint inflammation correlates with cartilage structural damage are still unclear. We induced OA via destabilization of the medial meniscus (DMM) in NFκB luciferase reporter mice, whose bioluminescent signal reflects the activity of NFκB, a central mediator of inflammation. Bioluminescence imaging data showed that DMM and sham control joints had a similar surge of inflammation at 1-week post-surgery, but the DMM joint exhibited a delay in resolution of inflammation in subsequent weeks. A similar trend was observed with synovitis, which we found to be mainly driven by synovial cell density and inflammatory infiltration rather than synovial lining thickness. Interestingly, an association between synovitis and collagen structural damage was observed in early OA. Using Second Harmonic Generation (SHG) imaging, we analyzed collagen fiber organization in articular cartilage. Zonal differences in collagen fiber thickness and organization were observed as soon as OA initiated after DMM surgery, and persisted over time. Even at 1-week post-surgery, the DMM joint showed a decrease in collagen fiber thickness in the deep zone and an increase in collagen fiber disorganization in the superficial zone. Since we were able detect and quantify collagen structural changes very early in OA development by SHG imaging, we concluded that SHG imaging is a highly sensitive tool to evaluate pathological changes in OA. In summary, this study uncovered a dynamic profile of inflammation and joint cartilage damage during OA initiation and development, providing novel insights into OA pathology.

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“…Moreover, since articular cartilage is not innervated, approximately 50% of the patients with radiological changes of OA are symptomatic; therefore, the treatment is based on symptoms rather than radiological changes. Even a successful CPA might have a minimal effect on symptoms, leading to patients being reluctant to adhere to a therapy that does not improve their symptoms [50].…”

Section: Mri Assessmentmentioning

confidence: 99%

Clinical Efficacy of a Single-dose of Platelet Rich Plasma in the Management of Early Knee Osteoarthritis: A Randomized Controlled Study With Mri Assessment and Evaluation of Optimal Dose

Bansal¹,

Leon

Pont³

et al. 2020

Preprint

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Background: Osteoarthritis (OA) causes substantial physical disability that limits a person's ability to indulge in daily activities. Non-steroidal anti-inflammatory drugs provide only minimal symptomatic benefit and are associated with mild to severe side effects, thus limiting its continuous use. This being the case, new alternate healing strategies with minimal adverse effects are being explored scientifically. In our study we have attempted to evaluate the clinical efficacy of a single dose of Platelet Rich Plasma (PRP) in treating osteoarthritis. Our primary objectives are:i) To optimise the correct dose of PRP preparation to achieve therapeutic relief in knee OAii) To identify the therapeutic efficacy of PRP in selected patients suffering from symptomatic primary knee OA through Randomized Clinical Trials and analyse the possible outcome using MRI analysis.Methods: A randomized, double-blind, 12-month, placebo-controlled study was conducted in 100 outpatients. PRP was prepared from the blood drawn from the subjects and administered intra-articularly guided by ultrasound. The degree of pain was assessed using WOMAC scores, the International Knee Documentation Committee score (IKDC) and six-minute pain free walking distance. The joint space width and articular cartilage thickness was evaluated through x-ray, ultrasonagraphy and MRI.Result: PRP with absolute count of approximately 100 billion platelets brings out significant therapeutic relief. The WOMAC scores showed reduction from 54.7 at baseline to 28.8 at one month, and 29.9 at 3 months showing efficacy of PRP over placebo. Improvement was evident in one month scores of IKDC tests (Baseline- 53.6; 1 month - 76.9) and VAS (Baseline - 5.8; 1 month - 2.46) followed by slight decline at 3, 6-month and one-year scores. Similarly, the pain-free distance covered during a 6-min walk was significantly improved at one month in both the groups (PRP-146 ft.; placebo-122 ft; p value <0.001). No change is seen on MRI and Joint space width.Conclusion: 7 times Concentration and absolute count of 100 billion platelets is crucial in a PRP formulation to be therapeutically effective in alleviating symptoms in moderate knee OA. The results indicate prevention of structural modification in the PRP group and better chondroprotective effects compared to placebo group.Trial Registration: This study has been registered in the US Clinical Trial Registry (U.S. National Library of Medicine) with Trial registration no. 04198467. Date of registration: December 13, 2019. (Retrospectively registered) URL - https://clinicaltrials.gov/ct2/show/NCT04198467?term=04198467&draw=2&rank=1

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Elevated adiabatic T_1ρ and T_2ρ in articular cartilage are associated with cartilage and bone lesions in early osteoarthritis: A preliminary study

Abstract: 2 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;46:678-689.

Cited by 26 publications

References 40 publications

3D adiabatic T_1ρ prepared ultrashort echo time cones sequence for whole knee imaging

3D adiabatic T_1ρ prepared ultrashort echo time cones sequence for whole knee imaging

Bioluminescence and second harmonic generation imaging reveal dynamic changes in the inflammatory and collagen landscape in early osteoarthritis

Clinical Efficacy of a Single-dose of Platelet Rich Plasma in the Management of Early Knee Osteoarthritis: A Randomized Controlled Study With Mri Assessment and Evaluation of Optimal Dose

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Elevated adiabatic T1ρ and T2ρ in articular cartilage are associated with cartilage and bone lesions in early osteoarthritis: A preliminary study

Abstract: 2 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;46:678-689.

Cited by 26 publications

References 40 publications

3D adiabatic T1ρ prepared ultrashort echo time cones sequence for whole knee imaging

3D adiabatic T1ρ prepared ultrashort echo time cones sequence for whole knee imaging

Bioluminescence and second harmonic generation imaging reveal dynamic changes in the inflammatory and collagen landscape in early osteoarthritis

Clinical Efficacy of a Single-dose of Platelet Rich Plasma in the Management of Early Knee Osteoarthritis: A Randomized Controlled Study With Mri Assessment and Evaluation of Optimal Dose

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Elevated adiabatic T_1ρ and T_2ρ in articular cartilage are associated with cartilage and bone lesions in early osteoarthritis: A preliminary study

3D adiabatic T_1ρ prepared ultrashort echo time cones sequence for whole knee imaging

3D adiabatic T_1ρ prepared ultrashort echo time cones sequence for whole knee imaging