Elevated Antibody Titers to Porphyromonas gingivalis as a Possible Predictor of Ischemic Vascular Disease

Abstract

Aim: Limited epidemiological studies have investigated the relationship between ischemic vascular disease and periodontitis in non-Western populations. We investigated this relationship in a Japanese cohort by measuring serum titers of antibodies to periodontopathic bacteria. Methods: As part of the Tokamachi-Nakasato cohort study, we followed up 7021 participants regarding cardiovascular events over 5 years, and observed 99 ischemic vascular events: 66 cerebral infarctions and 33 cases of ischemic heart disease (IHD). For a nested case-control study, we selected 495 sex-and age-matched control subjects. Conditional logistic regression analysis was used to estimate the odds ratios (OR) and 95% confidence intervals (CI) of ischemic vascular events associated with antibody titers to Porphyromonas gingivalis FDC381 and SU63. Multivariable models were adjusted for traditional cardiovascular risk factors using propensity scores. Results: The highest tertile category of antibody titers to P. gingivalis FDC381 in men was significantly associated with an increased risk of cerebral infarction in only the crude model. The 2nd and 3rd tertile categories of antibody titers to P. gingivalis SU63 were significantly associated with an increased risk of cerebral infarction in men (multivariable ORs (95% CIs) were 7.12 (1.51-33.5) and 9.03 (1.97-41.5), respectively). The association was not appreciably modified when we further adjusted for serum high-sensitivity C-reactive protein levels. Antibody titers to P. gingivalis were not dose-dependently associated with the risk of IHD. Conclusion: High serum antibody titers to P. gingivalis SU63 could be a predictor of cerebral infarction in Japanese men independent of traditional risk factors and inflammation. J Atheroscler Thromb, 2011; 18:808-817.

Association of serum immunoglobulin-G to Porphyromonas gingivalis with acute cerebral infarction in the Chinese population

“…[ 14 ] In Japanese male subjects, IgG antibodies to P. gingivalis SU63 were significantly elevated in cerebral infarction patients. [ 15 ] The lifestyle and ethnicity of the study population were different, but the results were consistent. These findings suggest that P. gingivalis has specific biological effects or may induce specific host responses related to cerebral infarction.…”

Increased serum PCSK9, a potential biomarker to screen for periodontitis, and decreased total bilirubin associated with probing depth in a Japanese community survey

“…The levels of serum biomarkers (interleukin‐6, TNF‐α, sCD14, hs‐CRP, PCSK9, MPO, MMP‐3, ADPN, and TBIL) shared between periodontitis and atherosclerotic disease were compared between periodontally healthy subjects and those with periodontal disease (Figure ). The concentrations of PCSK9 and hs‐CRP were significantly higher in subjects with periodontal disease than in periodontally healthy subjects ( P = .001 and .042, respectively), whereas TBIL was significantly lower in subjects with periodontal disease ( P = .046).…”

“…Over the past few decades, several serum biomarkers and molecules that reflect the host response to periodontitis have been reported, such as high‐sensitivity C‐reactive protein (hs‐CRP), tumor necrosis factor (TNF)‐α, interleukin‐6, soluble (s) CD14, and specific antibodies to periodontal bacteria . These markers are used to monitor inflammation and are also possible mediators linking periodontal inflammation to systemic diseases.…”

Periodontitis and the outcome of atrial fibrillation ablation: Porphyromonas gingivalis is related to atrial fibrillation recurrence

“…32 P. gingivalis type IV is the most frequently detected strain in human cardiovascular specimens 33 and is associated with ischemic cardiac and cerebral disease. 34,35 Nagasaki et al 36…”