2020
DOI: 10.1007/s43188-020-00060-3
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Elevated anxiety, hypoactivity, memory deficits, decreases of brain serotonin and 5-HT-1A receptors expression in rats treated with omeprazole

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Cited by 20 publications
(9 citation statements)
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“…Indeed, it can be speculated that treatment options available for any one of the aforesaid disease conditions can be reciprocally beneficial to other. Nevertheless, in recent years, there has been a rising concern about the adverse effects of PPIs as some reports indicated that PPIs treatment has been associated with the alteration of the neuroplasticity and development of anxiety [ 9 , 10 , 11 , 12 ].…”
Section: Discussionmentioning
confidence: 99%
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“…Indeed, it can be speculated that treatment options available for any one of the aforesaid disease conditions can be reciprocally beneficial to other. Nevertheless, in recent years, there has been a rising concern about the adverse effects of PPIs as some reports indicated that PPIs treatment has been associated with the alteration of the neuroplasticity and development of anxiety [ 9 , 10 , 11 , 12 ].…”
Section: Discussionmentioning
confidence: 99%
“…Earlier, a case study indicated that a young girl who received omeprazole treatment along with some anticholinergic and serotonergic medications displayed alteration of the mental state [ 28 ]. Recently, Ali SB and his co-workers reported that the intraperitoneal administration of omeprazole in experimental rats induces anxiety, sedentary behavior, and neurocognitive impairments due to lowered levels of serotonin and decreased expression of the serotonin 1A receptor in the brain [ 9 ]. Interference of omeprazole with the biochemical pathways of serotonin and acetylcholine has been linked to the development of neurological defects and behavioral abnormalities [ 9 , 29 ].…”
Section: Discussionmentioning
confidence: 99%
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“…Furthermore, hypergastrinemia caused by PPI may strengthen cytokine expression in the brain to induce depressive and anxiety‐like conditions 17 . Similarly, in a recent experimental rat model, anxiety‐like behavior and a decline in neurotransmission of serotonin and dopamine in the brain was detected shortly after short‐term PPI administration (15 days) 18 . Further studies are needed to understand potential mechanisms linking PPI to depression and anxiety.…”
Section: Discussionmentioning
confidence: 99%
“…For amplification and quantification of 5-HT1A gene, the method defined by Ali et al 15 was adopted. Expression of β-actin, a constitutively expressed gene was used as control in RNA expression studies.…”
Section: Methodsmentioning
confidence: 99%