Elevated Apolipoprotein B/A-1 Ratio is Associated With an Increased Risk of Aortic Stenosis: Experience From the AMORIS Cohort

Ivert, Torbjörn; Hammar, Niklas; Talbäck, Mats; Malmström, Håkan; Leander, Karin; Walldius, Göran

doi:10.1016/j.hlc.2020.12.005

Cited by 6 publications

(7 citation statements)

References 27 publications

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“…Many clinical studies have demonstrated that ApoB/ApoA-I is a quite good predictive indicator for disease severity and prognosis. It is independently associated with acute coronary syndrome, diabetes, aortic stenosis, cancer, insulin resistance, and carotid intima media thickness (12)(13)(14)(15)(16)(17) ApoA-I, and ApoB/ApoA-I ratios are also associated with many neurological diseases and immune-inflammatory diseases.…”

Section: Introductionmentioning

confidence: 99%

Elevated ApoB/ApoA-I ratio is associated with acute anti-N-Methyl-D-aspartate receptor encephalitis, but not disease outcomes

Liu

et al. 2022

Front. Neurol.

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ObjectiveThe purpose of the present study is to clarify the relationship between the apolipoprotein B100/apolipoprotein A-I (ApoB/ApoA-I) ratio and anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis.MethodsA total of 71 patients with anti-NMDAR encephalitis were included in this study, and their ApoB/ApoA-I ratios in baseline and follow-up were retrospectively analyzed.ResultsThe ApoB/ApoA-I ratio was closely correlated with the baseline-modified Rankin scale (mRS) score of >3 in patients with anti-NMDAR encephalitis. A subgroup analysis showed obvious differences between the high and low ApoB/ApoA-I ratio groups. The ApoB/ApoA-I ratio was positively correlated with intensive care unit (ICU) treatment, length of hospital stay, baseline mRS score, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR). The ratios of the high and low ApoB/ApoA-I groups both improved in the follow-up.ConclusionThe increased ApoB/ApoA-I ratio is associated with acute anti-NMDAR encephalitis, but not disease outcomes. Serum ApoB/ApoA-I ratio was related to inflammation and immunity in peripheral blood. The findings might provide a new idea for further exploration of the pathogenesis and treatment of anti-NMDAR encephalitis.

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Section: Introductionmentioning

confidence: 99%

Elevated ApoB/ApoA-I ratio is associated with acute anti-N-Methyl-D-aspartate receptor encephalitis, but not disease outcomes

Liu

et al. 2022

Front. Neurol.

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“…Although ApoA1/HDL should not impact the ALK1-mediated transcytosis, the data implies that ApoA1/HDL can effectively compete with LDL for the SR-BI-mediated transcytosis pathway. The ratio of the serum levels of ApoB: ApoA1 is associated with the severity of CVD, including the risk of aortic stenosis, and is predictive for mortality in patients with heart failure ( 65 , 66 , 67 ). Serum levels of ApoA1 in healthy patients are ∼1.5 g/L in healthy volunteers and slightly lower in those at risk for myocardial infarction, ∼1.25 g/L ( 68 ), and in the same groups, the ApoB levels were 1.08 g/L and 1.18 g/L, respectively.…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein A1 and high-density lipoprotein limit low-density lipoprotein transcytosis by binding SR-B1

Fung,

Ho,

et al. 2024

Journal of Lipid Research

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“…Fourth, several potential confounding factors may also have been ignored, such as the markers of inflammation and oxidative stress. Finally, previous researchers have stated that patients should be evaluated for stenosis, prognosis, and ischemic heart disease; we did not evaluate these variables [ 61 , 62 ]. Nevertheless, this study did provide a new perspective on the pathology of AF.…”

Section: Discussionmentioning

confidence: 99%

Case-Control Study to Investigate the Association Between Serum Apolipoprotein B/A1 Ratio and Atrial Fibrillation by Sex in 920 Patients from China

et al. 2022

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Background The serum apolipoprotein B/A1 ratio (APOB/APOA1) has been shown to predict cardiovascular events, whereas the effect of the APOB/APOA1 ratio on atrial fibrillation (AF) is less known. We investigated the association between the APOB/APOA1 ratio and AF by sex in 920 patients from China. Material/Methods We reviewed clinical data on 1840 hospitalized patients, including 920 patients with AF (male/female: 460/460, age: 68.62±10.36 years) and 920 age- and sex-matched patients without AF with sinus rhythm in China between January 2019 and September 2021. Pearson correlation analysis was performed to investigate the correlation between APOB/APOA1 ratio and AF-related metabolic factors. Logistic regression analysis was used to determine the odds ratios (ORs) and 95% confidence intervals (CIs). Results Low serum APOB/APOA1 ratios in male and female patients were significantly associated with AF after adjusting for confounding factors (OR 0.159, 95% CI 0.058–0.432, P <0.05). Serum APOB/APOA1 ratio was positively correlated with triglyceride (TG) (r=0.146, P <0.05) and total cholesterol (TC) (r=0.227, P <0.05) and was negatively correlated with albumin (ALB) (r=−0.128, P <0.05) and prealbumin (PAB) (r=−0.107, P <0.05). There was no significant difference of APOB/APOA1 ratio in different subtypes, complications, and statin use in patients with AF ( P >0.05). Conclusions A low serum APOB/APOA1 ratio in male and female patients from China was significantly related to AF. This finding implies that a low serum APOB/APOA1 ratio may be associated with the causes of AF. Further studies are needed to determine causalities.

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Elevated Apolipoprotein B/A-1 Ratio is Associated With an Increased Risk of Aortic Stenosis: Experience From the AMORIS Cohort

Cited by 6 publications

References 27 publications

Elevated ApoB/ApoA-I ratio is associated with acute anti-N-Methyl-D-aspartate receptor encephalitis, but not disease outcomes

Elevated ApoB/ApoA-I ratio is associated with acute anti-N-Methyl-D-aspartate receptor encephalitis, but not disease outcomes

Apolipoprotein A1 and high-density lipoprotein limit low-density lipoprotein transcytosis by binding SR-B1

Case-Control Study to Investigate the Association Between Serum Apolipoprotein B/A1 Ratio and Atrial Fibrillation by Sex in 920 Patients from China

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