Elevated Bladder Cancer Risk Due to Colorants—A Statewide Case-Control Study in North Rhine-Westphalia, Germany

Golka, Klaus; Heitmann, P; Gieseler, Frank; Hodzic, Jasmin; Masche, N; Bolt, Hermann M.; Geller, Frank

doi:10.1080/15287390801985869

Cited by 26 publications

(11 citation statements)

References 21 publications

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“…† For convenience reasons only the first author is given. Studies 17 18 26 33 35 37 41 42 44–48 51 52 55 56 with no definition or unsuitable definition for job held were excluded form this analysis.…”

Section: Resultsmentioning

confidence: 99%

Bladder cancer among hairdressers: a meta-analysis

et al. 2010

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BackgroundOccupational risks for bladder cancer in hairdressers by using hair products have been examined in many epidemiological studies. But owing to small sample sizes of the studies and the resulting lack of statistical power, the results of these studies have been inconsistent and significant associations have rarely been found.MethodsWe conducted a meta-analysis to determine summary risk ratios (SRRs) for the risk of bladder cancer among hairdressers. Studies were identified by a MEDLINE, EMBASE, CENTRAL search and by the reference lists of articles/relevant reviews. Statistical tests for publication bias and for heterogeneity as well as sensitivity analysis were applied. In addition, the study quality and the risk of bias were assessed using six criteria.Results42 studies were included and statistically significantly increased risks around 1.3–1.7 were found for all but one analysis. The SRR increased with duration of employment from 1.30 (95% CI 1.15 to 1.48) for ‘ever registered as hairdresser’ to 1.70 (95% CI 1.01 to 2.88) for ‘job held ≥10 years’. No difference was found between the risk for smoking-adjusted data (SRR 1.35, 95% CI 1.13 to 1.61) and no adjustment (SRR 1.33, 95% CI 1.18 to 1.50). Studies assessed as being of high quality (n=11) and of moderate quality (n=31) showed similar SRRs. There was no evidence of publication bias or heterogeneity in all analyses.ConclusionIn summary, our results showed an increased and statistically significant risk for bladder cancer among hairdressers, in particular for hairdressers in jobs held ≥10 years. Residual confounding by smoking cannot be totally ruled out. Because of the long latency times of bladder cancer it remains an open question whether hairdressers working prior to 1980 and after 1980, when some aromatic amines were banned as hair dye ingredients, have the same risk for bladder cancer.

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Section: Resultsmentioning

confidence: 99%

Bladder cancer among hairdressers: a meta-analysis

et al. 2010

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“…Thousands of synthetic hazardous chemical substances used in cosmetics industry 1 and potential health hazards in occupational environment of hairdressers, including biological, chemical, physical, and ergonomic factors, have a negative impact on individual’s health. 2 An association between the occupation of hairdressing and musculoskeletal, 3 –5 dermal complications, 6 –9 cancer of breast, 10 liver 11 and bladder, 12 fertility concerns, and gynaecological health 13 –15 were documented. Chronic bronchitis, asthma, asthma-like symptoms, allergy, and other respiratory illnesses were observed in several studies.…”

Section: Introductionmentioning

confidence: 99%

Occupational phthalate exposure and health outcomes among hairdressing apprentices

et al. 2016

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We studied occupational exposure to phthalates from first-morning-void urine sample of hairdressing apprentices by HPLC-MS/MS analyses and association with health status. Metabolites of mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono ethyl phthalate (MEP), mono- n-butyl phthalate (MnBP) and mono-iso-butyl phthalate (MiBP) were detected in all urine samples, followed by metabolites mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) and mono(2-etylhexyl) phthalate (MEHP) occurring in 97.06% and 86.76% of samples, respectively. Positive associations for females were observed between MnBP and fat-free mass index (FFMI) and age; negative associations were found between MEHP, MEOHP, MEHHP, sum of MEHP, MEHHP, MEOHP and vital capacity and also between MEHP and forced vital capacity (FVC of predicted value (PV)). Lengths of exposure were associated to MnBP, MEHHP, and MEP. We also documented positive associations between anthropometry (body mass index, waist-to-height ratio (WHtR), FFMI, fat mass index) and pulmonary function FVC% of PV for females and negative associations between WHtR, waist-to-hip ratio, FFMI and ratio of forced expiratory volume in 1 s (FEV1) to FVC (FEV1/FVC). We assume that factors of occupational environment of hairdressing apprentices are affected by phthalates and resulted in negative outcomes in breathing mechanism and influence of body composition. Adipose tissue could play role as confounding factor in urine excretion of phthalates because of their lipid solubility and accumulation.

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“…The BLadder cancer Epidemiology and Nutritional Determinants (BLEND) consortium currently consists of 19 case-control studies and 14 cohort studies investigating the association between lifestyle behaviours and UBC risk. For this analysis, we included 15 case-control studies providing complete data on smoking behaviour, including; smoking status, intensity and duration, These included 6,824 cases and 17,727 controls originating from Italy (13)(14)(15), Germany (16,17), Belgium (18), Sweden (19), Canada (20), the USA (21)(22)(23)(24)(25)(26) and China (27). All smoking data were either collected through interview-administered questionnaires (n=6) or self-administered questionnaires (n=9).…”

Section: Study Datamentioning

confidence: 99%