Elevated blood eosinophils in early infancy are predictive of atopic dermatitis in children with risk for atopy

Roßberg, Siri; Gerhold, Kerstin; Geske, Thomas; Zimmermann, Kurt; Menke, G; Wahn, Ulrich; Hamelmann, Eckard; Lau, Susanne

doi:10.1111/pai.12607

Cited by 10 publications

(9 citation statements)

References 41 publications

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“…On the contrary, BT did not play any diagnostic role in children with drug hypersensitivity . Supporting previous observations that EE had reflected the present atopic status, elevated EE at 4 weeks of age had a predictive value for the onset of AD at 7 months, 1, 2, and 3 years of age in a birth cohort with high risk for atopy . The chemokine CCL17 has been reported to correlate with the disease severity in infants suffering from AD sensitized against food or airborne allergens .…”

Section: Biomarkers Of Disease Severitysupporting

confidence: 77%

“…49 Supporting previous observations that EE had reflected the present atopic status, 50 elevated EE at 4 weeks of age had a predictive value for the onset of AD at 7 months, 1, 2, and 3 years of age in a birth cohort with high risk for atopy. 51 The chemokine CCL17 has been reported to correlate with the disease severity in infants suffering from AD sensitized against food or airborne allergens. 52 Interestingly, this correlation was higher for patients sensitized to food allergens and CCL17 was found mainly in the (inflamed) skin but not in the gut.…”

Section: Biomarkers Of Disease Severitymentioning

confidence: 99%

See 1 more Smart Citation

Food allergy and atopic dermatitis: Prediction, progression, and prevention

Mastrorilli

Caffarelli

Hoffmann‐Sommergruber

2017

Pediatric Allergy Immunology

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The rising burden of allergic diseases in childhood requires a compelling need to identify individuals at risk for atopy very early in life or even predict the onset of food allergy and atopic dermatitis since pregnancy. The development and clinical phenotypes of atopic diseases in childhood depend on a complex interaction between genetic and environmental factors, such as allergen exposure, air pollution, and infections. Preventive strategies may include avoidance measures, diet supplements, and early complementary food introduction. Overall, the management of allergic diseases has been improving to date toward a patient's tailored approach. This review will cover the current understanding of risk factors, prediction, and management of food allergy and atopic dermatitis in childhood and discuss how these may contribute to the modification of the natural history of food allergy and atopic dermatitis.

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Section: Biomarkers Of Disease Severitysupporting

confidence: 77%

Section: Biomarkers Of Disease Severitymentioning

confidence: 99%

Food allergy and atopic dermatitis: Prediction, progression, and prevention

Mastrorilli

Caffarelli

Hoffmann‐Sommergruber

2017

Pediatric Allergy Immunology

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“…Allergic diseases may share common mechanisms in the pathogenesis [25, 26]. In this regard, eosinophil plays a key role in the pathogenesis and development of atopic disease including asthma and eczema [14, 27]. Eosinophil secretes cytotoxic granules including major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil peroxidase (EPO), and eosinophil-derived neurotoxin (EDN) [14].…”

Section: Discussionmentioning

confidence: 99%

“…Eosinophil secretes cytotoxic granules including major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil peroxidase (EPO), and eosinophil-derived neurotoxin (EDN) [14]. Eosinophil granules contain a crystalloid core composed of MBP-1 and a matrix composed of ECP, EDN, and EPO [27]. MBP, EPO and ECP are toxic to a variety of cells and tissues, including heart, brain, and bronchial epithelium [28, 29].…”

Section: Discussionmentioning

confidence: 99%

Analysis of the predicting factors of recurrent wheezing in infants

et al. 2019

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BackgroundClinically, asthma in children under 5 years old is under estimated because lack of diagnostic criteria. The current study was, therefore, designed to identify the predicting factors for recurrent wheezing in infants.MethodsOne hundred forty-five infants under 3-year old hospitalized with respiratory diseases were enrolled into this study. Patients were followed up for one-year period after being discharged from the hospital and were, then, divided into recurrent wheezing group and non-recurrent wheezing group based on whether there was recurrent wheezing or not. Wheezing or recurrent wheezing was specifically monitored in addition to blood tests for allergic and respiratory diseases.ResultsThe prevalence of eczema and respiratory syncytial virus (RSV) infection were significantly higher in recurrent wheezing group than in control group (74.2% vs 45.8%; 32.3% vs. 13.3%, respectively, both P < 0.05); the percentage of blood eosinophil and serum eosinophil-derived neurotoxin (EDN) concentration at admission were also higher in recurrent wheezing group than in control group (3.10 ± 2.54% vs. 1.31 ± 1.15%; 68.67 ± 55.05 ng/mL vs. 27. 36 ± 19.51 ng/mL; respectively, both P < 0.001). Multivariate logistic regression analysis on eosinophil count and serum EDN concentration in predicting recurrent wheezing revealed that the eosinophil count showed the lowest sensitivity (51.6%) and highest specificity (90.4%), with the area under the ROC curve (AUC) of 0.752 ± 0.041; and that, in contrast, the serum EDN showed the highest sensitivity (88.7%) and lowest specificity (56.6%), with AUC of 0.795 ± 0.037.ConclusionCombination of eosinophil count and serum EDN measurement may be better to predict the risk of recurrent wheezing in early life of childhood.

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“…Dumas et al [28] analyzed the prospective data of 921 hospitalized children with bronchiolitis in 17 centers in the United States, and found that the risk of recurrent wheezing was signi cantly increased in children with eczema. It has been con rmed that eosinophils play a key role in the pathogenesis and development of atopic diseases including asthma and eczema [29,30] . Accordingly, one study [31] reported that recurrent wheezing at 36 months after bronchiolitis in infants was associated with eosinophilia.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for recurrent wheezing after bronchiolitis in infants: 2-year follow up in China

Chen

et al. 2020

Preprint

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Background: Infants with bronchiolitis have an increased risk of developing recurrent wheezing and asthma. However, the association between bronchiolitis and recurrent wheezing remains controversial.Objective: To investigate the incidence of post-bronchiolitis recurrent wheezing and associated risk factors.Methods: Infants with bronchiolitis were enrolled from November 2016 through March 2017. We also enrolled 24 healthy children with no history of wheezing from the department of children's health prevention as a control group. Nasopharyngeal aspirates were obtained for detection of respiratory viruses which were analyzed by reverse transcriptase polymerase chain reaction (RT-PCR) and direct immunofluorescent assay. Serum cytokines including TSLP, IL2, IL13, TIMP-1, MMP-9, IL33, IL5, IL4, IL25, TNF- α and MIP-1α were measured by flow cytometry. Patients were followed every 3 months for a duration of 2 years by telephone or at outpatient appointments.Results: We enrolled 89 infants, of which 81 patients were successfully followed up. In total, 22.2% of patients experienced recurrent wheezing episodes. The proportion of patients with eczema, systemic glucocorticoid use and patients with moderate-to-severe disease were significantly higher in the recurrent wheezing group than the non-recurrent wheezing group (83.3% vs 52.4%; 66.7% vs 36.5%; 61.1% vs 33.3%, respectively, all P<0.05); The serum level of TNF‑ α was lower in the recurrent wheezing group (P<0.05), and the serum levels of IL-4, IL-5, IL-25, IL-33 were significantly higher among patients without recurrent wheezing (P<0.05). Logistic regression analysis showed that eczema was an independent risk factor for post-bronchiolitis recurrent wheezing (odds ratio [OR]=7.488; 95% confidence interval [CI], 1.447–38.759; P=0.016). Conclusion: The incidence of recurrent wheezing among infants after contracting bronchiolitis was 22.2% during a 2-year follow-up. Eczema was the only independent risk factor identified and no correlation was found between the specific virus and disease severity in children with post-bronchiolitis recurrent wheezing.

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Elevated blood eosinophils in early infancy are predictive of atopic dermatitis in children with risk for atopy

Cited by 10 publications

References 41 publications

Food allergy and atopic dermatitis: Prediction, progression, and prevention

Food allergy and atopic dermatitis: Prediction, progression, and prevention

Analysis of the predicting factors of recurrent wheezing in infants

Risk factors for recurrent wheezing after bronchiolitis in infants: 2-year follow up in China

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