Elevated cardiac troponin T is associated with increased left ventricular mass index and predicts mortality in continuous ambulatory peritoneal dialysis patients

Prognostic Value of Cardiac Troponin T Is Independent of Inflammation, Residual Renal Function, and Cardiac Hypertrophy and Dysfunction in Peritoneal Dialysis Patients

“…This contrasts with the study by deFilippi et al (10 ) that showed no relation between cTnT and LV mass or function, but is similar to other studies in hemodialysis patients (9,25 ). So far, only 2 studies have been done in a PD population (11,26 ). Both reported prognostic value of cTnT but were limited by very small sample size.…”

“…Some studies (8,9 ), including a recent metaanalysis (27 ), suggested that a cTnT concentration Ͼ0.1 g/L identified a subgroup of asymptomatic ESRD patients with poor survival and high risk of cardiac death. There is increasing evidence, however, that an even lower cTnT cutoff of Ͻ0.1 g/L (clinical threshold) was predictive of an increased all-cause and cardiovascular mortality (10,11,14 ). There was some suggestion from our Kaplan-Meier analysis that a cTnT Ͼ0.01 g/L was associated with more adverse cardiovascular outcomes.…”

“…On the other hand, our recent study indicated an incremental value of cTnT to conventional echocardiography in predicting circulatory congestion in peritoneal dialysis (PD) patients (15 ). cTnT correlates with left ventricular (LV) hypertrophy in ESRD patients without acute myocardial ischemia (9,11 ). The important question-whether cTnT remains prognostically significant after adjusting for important potential confounders such as coronary artery disease (CAD), cardiac hypertrophy and dysfunction, inflammation, and residual renal function (RRF)-has remained unanswered.…”

High-Sensitivity Troponin as a Predictor of Cardiac Events and Mortality in the Stable Dialysis Population

“…Previous analyses established this relationship but were limited by the use of earlier assays for troponin T (7,(22)(23)(24)28 ). We note a paucity of evidence from examination of hs-cTnT in the PD population.…”

The Relationship between Cardiac Troponins and Left Ventricular Mass Index in Patients with Chronic Renal Failure

“…[10][11][12] In recent studies, the presence of left ventricular hypertrophy (LVH), which is common in ESRD patients, has been associated with elevated cTnT in patients with ESRD. [12][13][14] However, in previous studies, investigators used generally single measurement of cardiac troponins. Therefore, the change of the cardiac troponins with time and its relationship with LVMI in patients with ESRD is not completely known.…”