Elevated CEA is associated with worse survival in recurrent rectal cancer

Cho, Won Kyung; Choi, Doo Ho; Park, Hee Chul; Park, Won; Yu, Jeong Il; Park, Young Suk; Park, Joon Oh; Lim, Ho Yeong; Kang, Won Ki; Kim, Hee Cheol; Cho, Yong Beom; Yun, Seong Hyeon; Lee, Woo Yong

doi:10.18632/oncotarget.22511

Cited by 18 publications

(11 citation statements)

References 20 publications

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“…In our study, patients with elevated CEA during diagnosis showed a higher rate of death due to CRC in comparison with their counterparts. Consistent findings were reported from similar other studies [35,36,37], indicating the relevance of CEA as a prognostic marker of CRC patients. Jessup et al suggested that the higher tumorigenic potential of CEA-producing tumors might be the possible reason for poor prognosis associated with high baseline CEA level [38].…”

Section: Discussionsupporting

confidence: 90%

Histological characteristics, survival pattern and prognostic determinants among colorectal cancer patients in Ethiopia: A retrospective cohort study

Teka

Yesuf

Hussien

et al. 2021

Heliyon

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Background: The incidence of colorectal cancer (CRC) and associated mortality are rising in low-and middleincome countries. In Ethiopia, colorectal cancer is among the leading causes of cancer morbidity and mortality in both sexes. Although some studies provided estimations on the national burden and regional distribution, the histological characteristics, survival pattern and determinants among colorectal cancer patients are not welldocumented.Aim: This study aimed to describe the histological characteristics, to determine the patterns of survival, and identify factors that determine mortality rate among CRC patients in Ethiopia. Methods: A retrospective cohort study was conducted among CRC patients registered at cancer treatment center of Tikur Anbessa Specialized Hospital, from January 2012 to December 2016. Data were extracted from a total of 161 patient medical records using a pretested abstraction form and supplemented by phone calls with the patients/caregivers. To determine colorectal cancer specific survival overtime, we performed a Kaplan-Meier survival analysis and significance of variation in survival across covariates and treatment categories was tested using log-rank test. A multivariable Cox proportional-hazards model was performed to identify determinants of survival after diagnosis with colorectal cancer. Results: Overall, the median survival time was 21 months [95%CI: 16-35], with two-, three-and five-year CRCspecific survival rates of 46.8%, 39.5% and 28.7% respectively. In the multivariable Cox regression model, the rate of death due to CRC is significantly higher for patients with elevated baseline carcinoembryonic antigen (CEA) level (Adjusted Hazard Ratio (AHR) ¼ 2.31, 95%CI: 1.27-4.19), stage IV at diagnosis (AHR ¼ 2.66, 95%CI: 1.44-4.91), and mucinous or signet-ring cell carcinoma histology type (AHR ¼ 4.92,). Moreover, patients who underwent surgery showed a better survival than those who did not (AHR ¼ 0.35, 95%CI: 0.14-0.88). Conclusion:In Ethiopia, patients diagnosed with CRC showed a low rate of cancer-specific survival. Histology type, stage of cancer and CEA level at diagnosis, and the type of treatment a patient received significantly determine mortality rate. Hence, cancer screening programs could help to detect the disease at an earlier stage and to initiate available treatments timely so as to extend the lifespan of CRC patients.

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Section: Discussionsupporting

confidence: 90%

Histological characteristics, survival pattern and prognostic determinants among colorectal cancer patients in Ethiopia: A retrospective cohort study

Teka

Yesuf

Hussien

et al. 2021

Heliyon

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“…Carcinoembryonic antigen (CEA) is considered as the prominent tumor biomarker for diagnosing various malignancies [192][193][194][195][196][197]. CEA is basically a glycoprotein with the size 180-200 kDa [198] and its expression and over-expression generally occur in mucosal cells and in several oncofetal tumor cells, respectively [199,200].…”

Section: Electrochemiluminescence-based Gqd-sensorsmentioning

confidence: 99%

Applications of Graphene Quantum Dots in Biomedical Sensors

Mansuriya

Altıntaş

2020

Sensors

190

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Due to the proliferative cancer rates, cardiovascular diseases, neurodegenerative disorders, autoimmune diseases and a plethora of infections across the globe, it is essential to introduce strategies that can rapidly and specifically detect the ultralow concentrations of relevant biomarkers, pathogens, toxins and pharmaceuticals in biological matrices. Considering these pathophysiologies, various research works have become necessary to fabricate biosensors for their early diagnosis and treatment, using nanomaterials like quantum dots (QDs). These nanomaterials effectively ameliorate the sensor performance with respect to their reproducibility, selectivity as well as sensitivity. In particular, graphene quantum dots (GQDs), which are ideally graphene fragments of nanometer size, constitute discrete features such as acting as attractive fluorophores and excellent electro-catalysts owing to their photo-stability, water-solubility, biocompatibility, non-toxicity and lucrativeness that make them favorable candidates for a wide range of novel biomedical applications. Herein, we reviewed about 300 biomedical studies reported over the last five years which entail the state of art as well as some pioneering ideas with respect to the prominent role of GQDs, especially in the development of optical, electrochemical and photoelectrochemical biosensors. Additionally, we outline the ideal properties of GQDs, their eclectic methods of synthesis, and the general principle behind several biosensing techniques.

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“…Carcinoembryonic antigen (CEA) is one of the major tumor markers associated with the diagnosis and controlling of malignant tumors, such as pancreatic, colorectal, lung, liver, breast, and gastric cancers [113][114][115][116][117][118]. It is an oncofetal glycoprotein with a molecular weight of 180-200 kDa [119], which is generally expressed by mucosal cells and overexpressed by various malignancies [120,121].…”

Section: Gqd-based Electrochemical Immunosensors For Cancer Diagnosismentioning

confidence: 99%

Graphene Quantum Dot-Based Electrochemical Immunosensors for Biomedical Applications

Mansuriya

Altıntaş

2019

Materials

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In the area of biomedicine, research for designing electrochemical sensors has evolved over the past decade, since it is crucial to selectively quantify biomarkers or pathogens in clinical samples for the efficacious diagnosis and/or treatment of various diseases. To fulfil the demand of rapid, specific, economic, and easy detection of such biomolecules in ultralow amounts, numerous nanomaterials have been explored to effectively enhance the sensitivity, selectivity, and reproducibility of immunosensors. Graphene quantum dots (GQDs) have garnered tremendous attention in immunosensor development, owing to their special attributes such as large surface area, excellent biocompatibility, quantum confinement, edge effects, and abundant sites for chemical modification. Besides these distinct features, GQDs acquire peroxidase (POD)-mimicking electro-catalytic activity, and hence, they can replace horseradish peroxidase (HRP)-based systems to conduct facile, quick, and inexpensive label-free immunoassays. The chief motive of this review article is to summarize and focus on the recent advances in GQD-based electrochemical immunosensors for the early and rapid detection of cancer, cardiovascular disorders, and pathogenic diseases. Moreover, the underlying principles of electrochemical immunosensing techniques are also highlighted. These GQD immunosensors are ubiquitous in biomedical diagnosis and conducive for miniaturization, encouraging low-cost disease diagnostics in developing nations using point-of-care testing (POCT) and similar allusive techniques.

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Elevated CEA is associated with worse survival in recurrent rectal cancer

Cited by 18 publications

References 20 publications

Histological characteristics, survival pattern and prognostic determinants among colorectal cancer patients in Ethiopia: A retrospective cohort study

Histological characteristics, survival pattern and prognostic determinants among colorectal cancer patients in Ethiopia: A retrospective cohort study

Applications of Graphene Quantum Dots in Biomedical Sensors

Graphene Quantum Dot-Based Electrochemical Immunosensors for Biomedical Applications

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