Elevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal administration in humans

Striepens, Nadine; Kendrick, Keith M.; Hanking, Vanessa; Landgraf, Rainer; Wüllner, Ullrich; Maier, Wolfgang; Hurlemann, René

doi:10.1038/srep03440

Cited by 421 publications

(398 citation statements)

References 27 publications

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“…Although we were unable to directly assess oxytocin in the CNS, this finding of elevated salivary oxytocin is consistent with studies in adult macaques that reported elevated CSF oxytocin levels 35-120 min after aerosolized oxytocin delivery (4,50). It is also consistent with studies in rodents reporting that intranasal oxytocin increases extracellular concentrations of oxytocin in behaviorally relevant brain regions, peaking 30-60 min after administration (51), and studies of elevated oxytocin in human CSF 75 min following intranasal administration (52). Although the relation between central and peripheral oxytocin levels has not been fully elucidated (e.g., ref.…”

Section: Discussionsupporting

confidence: 77%

Inhaled oxytocin increases positive social behaviors in newborn macaques

Simpson

Sclafani

Paukner

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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Early caregiver-infant interactions are critical for infants' socioemotional and cognitive development. Several hormones and neuromodulators, including oxytocin, affect these interactions. Exogenous oxytocin promotes social behaviors in several species, including human and nonhuman primates. Although exogenous oxytocin increases social function in adults-including expression recognition and affiliation-it is unknown whether oxytocin can increase social interactions in infants. We hypothesized that nebulized oxytocin would increase affiliative social behaviors and such effects would be modulated by infants' social skills, measured earlier in development. We also hypothesized that oxytocin's effects on social behaviors may be due to its anxiolytic effects. We tested these hypotheses in a blind study by nebulizing 7-to 14-d-old macaques (n = 28) with oxytocin or saline. Following oxytocin administration, infants' facial gesturing at a human caregiver increased, and infants' salivary oxytocin was positively correlated with the time spent in close proximity to a caregiver. Infants' imitative skill (measured earlier in development: 1-7 d of age) predicted oxytocin-associated increases in affiliative behaviors-lip smacking, visual attention to a caregiver, and time in close proximity to a caregiver-suggesting that infants with higher propensities for positive social interactions are more sensitive to exogenous oxytocin. Oxytocin also decreased salivary cortisol, but not stressrelated behaviors (e.g., scratching), suggesting the possibility of some anxiolytic effects. To our knowledge, this study provides the first evidence that oxytocin increases positive social behaviors in newborns. This information is of critical importance for potential interventions aimed at ameliorating inadequate social behaviors in infants with higher likelihood of developing neurodevelopmental disorder.imitation recognition | neonatal imitation | individual differences

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Section: Discussionsupporting

confidence: 77%

Inhaled oxytocin increases positive social behaviors in newborn macaques

Simpson

Sclafani

Paukner

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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“…First, two task-based fMRI scans were conducted: an emotional face-matching task (Koch et al, 2015) and a monetary (Nawijn et al, 2016a) and social (Nawijn et al, 2016b) incentive delay reward task. Hereafter, the resting-state scan was conducted, which began on average 72.51 min (±4.03) after intranasal spray administration, when neuropharmacological OT administration effects on cerebral blood flow (Paloyelis et al, 2014) and elevated OT levels in cerebrospinal fluid (Striepens et al, 2013) are still observed. During resting-state scanning, participants were instructed to relax and let their mind wander, with open eyes.…”

Section: Methodsmentioning

confidence: 99%

Intranasal Oxytocin Normalizes Amygdala Functional Connectivity in Posttraumatic Stress Disorder

Koch

Zuiden

Nawijn

et al. 2016

Neuropsychopharmacol

126

106

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The neuropeptide oxytocin (OT) has been suggested as a promising pharmacological agent for medication-enhanced psychotherapy in posttraumatic stress disorder (PTSD) because of its anxiolytic and prosocial properties. We therefore investigated the behavioral and neurobiological effects of a single intranasal OT administration (40 IU) in PTSD patients. We conducted a randomized, placebo-controlled, cross-over resting-state fMRI study in male and female police officers with (n = 37, 21 males) and without PTSD (n = 40, 20 males). We investigated OT administration effects on subjective anxiety and functional connectivity of basolateral (BLA) and centromedial (CeM) amygdala subregions with prefrontal and salience processing areas. In PTSD patients, OT administration resulted in decreased subjective anxiety and nervousness. Under placebo, male PTSD patients showed diminished right CeM to left ventromedial prefrontal cortex (vmPFC) connectivity compared with male trauma-exposed controls, which was reinstated after OT administration. Additionally, female PTSD patients showed enhanced right BLA to bilateral dorsal anterior cingulate cortex (dACC) connectivity compared with female trauma-exposed controls, which was dampened after OT administration. Although caution is warranted, our findings tentatively suggest that OT has the potential to diminish anxiety and fear expression of the amygdala in PTSD, either via increased control of the vmPFC over the CeM (males) or via decreased salience processing of the dACC and BLA (females). Our findings add to accumulating evidence that OT administration could potentially enhance treatment response in PTSD.

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“…Subjects were randomly assigned to either intranasal administration of OXT (24 IU; Syntocinon-Spray, Novartis; three puffs per nostril, each with 4 IU OXT) or PLC (sodium chloride solution) 30 min before the start of the fMRI. The intranasal administration of OXT has been shown to increase OXT concentration in the CSF (Striepens et al, 2013). Details on the tasks, fMRI procedure, and analyses can be found in the Supplementary Information.…”

Section: Experimental Designmentioning

confidence: 99%

An Oxytocin-Induced Facilitation of Neural and Emotional Responses to Social Touch Correlates Inversely with Autism Traits

Scheele

Kendrick

Khouri

et al. 2014

Neuropsychopharmacol

Self Cite

169

151

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Social communication through touch and mutual grooming can convey highly salient socio-emotional signals and has been shown to involve the neuropeptide oxytocin (OXT) in several species. Less is known about the modulatory influence of OXT on the neural and emotional responses to human interpersonal touch. The present randomized placebo (PLC)-controlled within-subject pharmacofunctional magnetic resonance imaging (fMRI) study was designed to test the hypothesis that a single intranasal dose of synthetic OXT (24 IU) would facilitate both neural and emotional responses to interpersonal touch in a context-(female vs male touch) and trait-(autistic trait load) specific manner. Specifically, the experimental rationale was to manipulate the reward value of interpersonal touch independent of the intensity and type of actual cutaneous stimulation administered. Thus, 40 heterosexual males believed that they were touched by either a man or a woman, although in fact an identical pattern of touch was always given by the same female experimenter blind to condition type. Our results show that OXT increased the perceived pleasantness of female, but not male touch, and associated neural responses in insula, precuneus, orbitofrontal, and pregenual anterior cingulate cortex. Moreover, the behavioral and neural effects of OXT were negatively correlated with autistic-like traits. Taken together, this is the first study to show that the perceived hedonic value of human heterosexual interpersonal touch is facilitated by OXT in men, but that its behavioral and neural effects in this context are blunted in individuals with autistic traits.

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Elevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal administration in humans

Cited by 421 publications

References 27 publications

Inhaled oxytocin increases positive social behaviors in newborn macaques

Inhaled oxytocin increases positive social behaviors in newborn macaques

Intranasal Oxytocin Normalizes Amygdala Functional Connectivity in Posttraumatic Stress Disorder

An Oxytocin-Induced Facilitation of Neural and Emotional Responses to Social Touch Correlates Inversely with Autism Traits

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