Elevated Cerebrospinal Fluid Vaccinia Antibodies in Multiple Sclerosis

Ch, Kempe; Takabayashi, Katsuhiko; Miyamoto, Hiroko; Mcintosh, Kenneth; Ww, Tourtellotte; Jm, Adams

doi:10.1001/archneur.1973.00490220086016

Cited by 36 publications

(7 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The frequency of occurrence of measles virus antibodies in cerebrospinal fluid (CSF) from patients with MS also is much higher than that in control patients (6). A similar observation has also been made for vaccinia antibodies (10), but a separate report could neither confirm this finding nor detect any antibodies to parainfluenza virus type 1 in CSF (5).…”

mentioning

confidence: 91%

Comparison of Antibodies Against Different Viruses in Cerebrospinal Fluid and Serum Samples from Patients with Multiple Sclerosis

et al. 1974

View full text Add to dashboard Cite

The occurrence of a local production in the central nervous system (CNS) of antibodies against different selected viruses was analyzed by comparison of titers in serum and cerebrospinal fluid samples from groups of 50 patients with multiple sclerosis from Finland, Norway, and Sweden. Measles antibodies were determined in hemagglutination inhibition, hemolysis inhibition, and nucleocapsid complement fixation tests; mumps, parainfluenza virus type 1, and rubella virus antibodies were determined in hemagglutination inhibition tests; and herpes simplex virus type 1 antibodies were determined in passive hemagglutination tests. For reference purposes tests were also made for adenovirus antibodies in penton hemagglutination enhancement tests and poliovirus antibodies in neutralization enhancement tests. Among the 150 multiple sclerosis patients, a local production of antibodies against measles virus was found in the CNS in 57%, against rubella virus in 19%, mumps virus in 15%, herpes simplex virus type 1 in 11%, and parainfluenza virus type 1 (Sendai) in 3T. A local production in the CNS of antibodies against any of the viruses studied was found in 71% of multiple sclerosis patients. These included 48, 16, and 7% that produced antibodies to one, two, and three or more viruses, respectively.

show abstract

mentioning

confidence: 91%

Comparison of Antibodies Against Different Viruses in Cerebrospinal Fluid and Serum Samples from Patients with Multiple Sclerosis

et al. 1974

View full text Add to dashboard Cite

show abstract

“…Elevation of CSF antibody levels to other viruses including mumps, rubella, vaccinia, and herpes has also been reported in MS [7,111. These findings support the supposition that MS may be due directly to a persistent infection.…”

mentioning

confidence: 92%

Cellular immune response to measles, mumps, and vaccinia viruses in multiple sclerosis

McFarland

McFarlin

1979

Annals of Neurology

View full text Add to dashboard Cite

The cell-mediated immune response to measles, mumps, and vaccinia viruses was studied in MS patients, normal controls, and neurological disease controls using a lymphocyte proliferation assay. A small but significant difference was found in the response to measles between the MS and normal control groups but not between the MS and neurological disease control groups. In each of the groups, the response of both peripheral blood leukocytes and purified T-cells to measles was significantly less than the response to mumps or vaccinia. The lower response to measles was not due to the presence of blocking factors or to lack of antigenicity of the measles virus preparation used in the assay. These findings suggest that differences exist in the normal immune response between these viruses. Precise quantitation of the immunological response to viruses in MS and other disease states will depend on identification of the various functionally reactive cell populations.

show abstract

“…Bereits 1962 fanden Adams und lmagawa, daß ein Teil dieser lokal produzierten Antikörper mit Masernantigenen reagiert. Diese Ergebnisse konnten bestätigt und dahingehend erweitert werden, daß bei der MS auch gegen andere neurotrope Viren wie Röteln, Zoster, Herpes und Mumps eine intrathekale Produktion auftreten kann (3,8,19,28,32,37,44,45,56,63,66,68), wobei diese Antikörper nicht mehr als 5-I0% der gesamten im ZNS synthetisierten IgG-Menge ausmachen. Die Bedeutung dieser Befunde wurde dadurch relativiert, daß von anderen Untersuchern eine intrathekale Synthese von Virusantikörpern auch bei anderen Erkrankungen als der MS -teilweise sogar bei nichtentzündlichen Prozessen -beschrieben wurde (19,20,54,55).…”

Section: Das Pathologisch Anatomische Substrat Derunclassified

Die diagnostische Wertigkeit der Liquoruntersuchung bei multipler Sklerose

1990

Fortschr Neurol Psychiatr

View full text Add to dashboard Cite

Multiple sclerosis ist a very frequent chronic inflammatory disease of the central nervous system. Since clinical and neuro-imaging findings often may be ambiguous, cerebrospinal fluid examination has received great importance for diagnosis. By that method it becomes possible to differentiate inflammatory from noninflammatory diseases. Furthermore, cerebrospinal fluid findings are discussed which seem to be characteristic for multiple sclerosis.

show abstract

Elevated Cerebrospinal Fluid Vaccinia Antibodies in Multiple Sclerosis

Cited by 36 publications

References 2 publications

Comparison of Antibodies Against Different Viruses in Cerebrospinal Fluid and Serum Samples from Patients with Multiple Sclerosis

Comparison of Antibodies Against Different Viruses in Cerebrospinal Fluid and Serum Samples from Patients with Multiple Sclerosis

Cellular immune response to measles, mumps, and vaccinia viruses in multiple sclerosis

Die diagnostische Wertigkeit der Liquoruntersuchung bei multipler Sklerose

Contact Info

Product

Resources

About