Elevated Cervical White Blood Cell Infiltrate Is Associated with Genital HIV Detection in a Longitudinal Cohort of Antiretroviral Therapy–Adherent Women

Henning, Tara; Kissinger, Patricia; Lacour, Nedra; Meyaski-Schluter, Mary; Clark, Rebecca A.; Amedee, Angela M.

doi:10.1086/656720

Cited by 26 publications

(31 citation statements)

References 45 publications

(58 reference statements)

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“…We found that 39.5% of women with undetectable PVL had detectable HIV-DNA in the genital tract, a rate very similar to those previously reported (median 34%, IQR = 30–40) [8]–[10], [15]–[17]. Overall, there was a positive correlation between HIV-DNA shedding in the genital tract and the level of HIV-DNA in PBMCs, although this correlation was less pronounced than the one we previously found between gut-associated lymphoïd tissue and blood [18].…”

Section: Discussionsupporting

confidence: 90%

HIV-DNA in the Genital Tract of Women on Long-Term Effective Therapy Is Associated to Residual Viremia and Previous AIDS-Defining Illnesses

et al. 2013

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ObjectivesTo assess the impact of long-term combined antiretroviral therapy (cART) on HIV-RNA and HIV-DNA levels in cervicovaginal secretions of HIV-1-infected women with sustained undetectable plasma RNA viral load (PVL); to explore factors predictive of residual viral shedding; and to evaluate the risk of heterosexual transmission.MethodsWomen with undetectable PVL (<50 copies/mL) for >6 months were included in this cross-sectional study. HIV-RNA and HIV-DNA were measured in blood and cervicovaginal lavage fluid (CVL). Women were systematically tested for genital infections. The risk of transmission to male partners during unprotected intercourse was estimated.ResultsEighty-one women composed the study population: all had HIV-RNA <40 copies/mL in CVL. HIV-DNA was detectable in CVL of 29/78 patients (37%). There was a weak positive correlation between HIV-DNA levels in PBMCs and CVL (r = 0.20; p = 0.08). In multivariate analysis, two factors were associated with HIV-DNA detection in CVL: previous AIDS-defining illnesses (OR = 11; 95%CI = 2–61) and current residual viremia (20

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Section: Discussionsupporting

confidence: 90%

HIV-DNA in the Genital Tract of Women on Long-Term Effective Therapy Is Associated to Residual Viremia and Previous AIDS-Defining Illnesses

et al. 2013

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“…2,31 Genital infections associated with significant inflammation, including gonorrhea, chlamydia, yeast, and herpes, have been associated with increased rates of genital HIV-1 RNA 32,33 and DNA 34 shedding while treatment of these infections has been associated with a decrease in the detection of HIV-1 in genital secretions. 35,36 In this study, the only infection significantly associated with increased HIV-1 RNA shedding was yeast vaginitis.…”

Section: Discussionmentioning

confidence: 99%

Interaction Between Lactobacilli, Bacterial Vaginosis-Associated Bacteria, and HIV Type 1 RNA and DNA Genital Shedding in U.S. and Kenyan Women

Mitchell

Balkus

Fredricks

et al. 2013

AIDS Research and Human Retroviruses

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Bacterial vaginosis has been associated with genital HIV-1 shedding; however, the effect of specific vaginal bacterial species has not been assessed. We tested cervicovaginal lavage from HIV-1-seropositive women for common Lactobacillus species: L. crispatus, L. jensenii, and seven BV-associated species: BVAB1, BVAB2, BVAB3, Leptotrichia, Sneathia, Megasphaera, and Atopobium spp. using quantitative PCR. We

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“…In general, although PVL directly correlates with vaginal viral load (VVL), increases in vaginal shedding may occur independent of PVL. 29 One serodiscordant couples study found no transmission where the infected person had a PVL of 1500 copies/mL or less. 30 Other studies, however, have found that any shedding of HIV-1 RNA in the vaginal compartment has the potential to increase the risk of sexual 30,31 and perinatal transmission.…”

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Co-occurrence of Trichomonas vaginalis and Bacterial Vaginosis and Vaginal Shedding of HIV-1 RNA

Fastring¹,

Amedee²,

Gatski³

et al. 2014

Sexually Transmitted Diseases

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Elevated Cervical White Blood Cell Infiltrate Is Associated with Genital HIV Detection in a Longitudinal Cohort of Antiretroviral Therapy–Adherent Women

Abstract: Despite antiretroviral therapy adherence and clinically suppressed plasma viremia, HIV was intermittently detected in genital secretions and was associated with subclinical inflammation and cells trafficking to the cervical mucosa.

Cited by 26 publications

References 45 publications

HIV-DNA in the Genital Tract of Women on Long-Term Effective Therapy Is Associated to Residual Viremia and Previous AIDS-Defining Illnesses

HIV-DNA in the Genital Tract of Women on Long-Term Effective Therapy Is Associated to Residual Viremia and Previous AIDS-Defining Illnesses

Interaction Between Lactobacilli, Bacterial Vaginosis-Associated Bacteria, and HIV Type 1 RNA and DNA Genital Shedding in U.S. and Kenyan Women

Co-occurrence of Trichomonas vaginalis and Bacterial Vaginosis and Vaginal Shedding of HIV-1 RNA

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