Elevated circulating levels of beta 2-microglobulin in patients with idiopathic dilated cardiomyopathy

Klappacher, G; Mundigler, Gerald; Papousek, Angelika; Pacher, Richard; Woloszczuk, W.; Ullrich, Robert C.; P, Buxbaum; Glogar, Dietmar

doi:10.1016/0002-9149(93)90723-p

Cited by 16 publications

(7 citation statements)

References 11 publications

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“…Similar observations of elevated NPT and/or β -2 M concentrations in dilated cardiomyopathy were noticed earlier [29–31]. In our DCM group like in previous data higher serum NPT and β -2 M concentrations correlated with lower left ventricular ejection fraction [30, 31]. The participation of inflammation and immune reactions in pathogenesis of heart failure was confirmed in clinical and experimental investigations.…”

Section: Discussionsupporting

confidence: 92%

“…In keeping with our results Klappacher et al found elevated β -2 M plasma level correlating with parameters of stimulated renin-angiotensin system and with T cellular hyperresponsiveness in DCM patients [31]. Caforio et al observed the higher mean level and the proportion of abnormal results of β -2 M in ischaemic but not in idiopathic cardiomyopathy [30].…”

Section: Discussionsupporting

confidence: 91%

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Neopterin and Beta-2 Microglobulin Relations to Immunity and Inflammatory Status in Nonischemic Dilated Cardiomyopathy Patients

Wojciechowska

Wodniecki

Wojnicz

et al. 2014

Mediators of Inflammation

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Background. The aim of the study was to assess the relationships among serum neopterin (NPT), β2-microglobulin (β2-M) levels, clinical status, and endomyocardial biopsy results of dilated cardiomyopathy patients (DCM). Methods. Serum NPT and β-2 M were determined in 172 nonischaemic DCM patients who underwent right ventricular endomyocardial biopsy and 30 healthy subjects (ELISA test). The cryostat biopsy specimens were assessed using histology, immunohistology, and immunochemistry methods (HLA ABC, HLA DR expression, CD3 + lymphocytes, and macrophages counts). Results. The strong increase of HLA ABC or HLA DR expression was detected in 27.2% patients—group A—being low in 72.8% patients—group B. Neopterin level was increased in patients in group A compared to healthy controls 8.11 (4.50–12.57) versus 4.99 (2.66–8.28) nmol/L (P < 0.05). β-2 microglobulin level was higher in DCM groups A (2.60 (1.71–3.58)) and B (2.52 (1.51–3.72)) than in the control group 1.75 (1.28–1.96) mg/L, P < 0.001. Neopterin correlated positively with the number of macrophages in biopsy specimens (P < 0.05) acute phase proteins: C-reactive proteins (P < 0.05); fibrinogen (P < 0.01); and NYHA functional class (P < 0.05) and negatively with left ventricular ejection fraction (P < 0.05). Conclusions. Neopterin but not β-2 microglobulin concentration reflected immune response in biopsy specimens. Neopterin correlated with acute phase proteins and stage of heart failure and may indicate a general immune and inflammatory activation in heart failure.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Neopterin and Beta-2 Microglobulin Relations to Immunity and Inflammatory Status in Nonischemic Dilated Cardiomyopathy Patients

Wojciechowska

Wodniecki

Wojnicz

et al. 2014

Mediators of Inflammation

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“…Using those estimates, it was found that eGFR B2M and eGFR cys were both associated with prevalent frailty. In the general elderly population, cystatin C has been correlated with various inflammatory markers, so the relationship between B2M level and frailty in older persons may be closely linked with inflammatory markers beyond those indicative of kidney dysfunction . Therefore, a high serum B2M level reflects a physiological decline in multiple body systems, and affected individuals may appear physically frail.…”

Section: Discussionmentioning

confidence: 99%

“…In the general elderly population, cystatin C has been correlated with various inflammatory markers, 18,19 so the relationship between B2M level and frailty in older persons may be closely linked with inflammatory markers beyond those indicative of kidney dysfunction. 20,21 Therefore, a high serum B2M level reflects a physiological decline in multiple body systems, and affected individuals may appear physically frail. The current study results are in accord with emerging evidence of the association between B2M and frailty.…”

Section: Discussionmentioning

confidence: 99%

Association Between Serum β₂‐Microglobulin Levels and Prevalent and Incident Physical Frailty in Community‐Dwelling Older Women

Kim

Suzuki

Kojima

et al. 2017

J American Geriatrics Society

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“…8 Increased levels of B2M are seen in patients with hematologic and autoimmune disorders 9,10 but also seem to be elevated under conditions of high cell turnover, ischemia, or cardiomyopathy. 11,12 In 1 study in uremic patients on hemodialysis, B2M was related to carotid intima-media thickness. 13 Shinkai et al have demonstrated that serum B2M is an independent predictor of mortality in older adults, possibly better than other inflammatory markers like C-reactive protein or cystatin C. 14 Furthermore, it has been shown that B2M is associated with coronary artery disease and more strongly with peripheral artery disease 11,15,16 (PAD).…”

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confidence: 99%

Beta 2 Microglobulin and the Risk for Cardiovascular Events in Patients With Asymptomatic Carotid Atherosclerosis

Amighi

Hoke²,

Mlekusch³

et al. 2011

Stroke

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Background and Purpose-Atherosclerosis is a chronic inflammatory disease. Ongoing inflammation is associated with elevated levels of beta 2 microglobulin (B2M). We investigated B2M levels in a large cohort of patients with carotid atherosclerosis for the occurrence of major adverse cardiovascular events. Methods-One thousand five of 1286 consecutive, neurologically asymptomatic patients with carotid atherosclerosis were followed for a median of 3 years (interquartile range, 2.5 to 3.5) for the occurrence of major adverse cardiovascular events, a composite of myocardial infarction, percutaneous coronary intervention, coronary bypass graft, stroke, and death. Results-We recorded 359 major cardiovascular events in 271 (27%) patients. B2M was significantly associated with the occurrence of major adverse cardiovascular events. With increasing quartiles of B2M, the adjusted hazard ratios were 1.19 (95% CI, 0.81 to 1.73), 1.51 (95% CI, 1.05 to 2.18), and 1.88 (95% CI, 1.26 to 2.79) compared with the lowest quartile, respectively (PϽ0.001). Adjusted hazard ratios for the occurrence of death, myocardial infarction, and stroke for increasing quartiles of B2M were 1.25 (95% CI, 0.92 to 1.70), 1.52 (95% CI, 1.12 to 2.06), and 1.62 (95% CI, 1.16 to 2.67) compared with the lowest quartile, respectively (PϽ0.001). Through statistical estimation of improvement in risk stratification, addition of B2M to baseline risk factors improved the risk stratification for major cardiovascular events, at least as much as high-sensitivity C-reactive protein or even better. Conclusions-B2M was independently and significantly associated with adverse cardiovascular outcome in patients with prevalent asymptomatic carotid atherosclerosis. (Stroke. 2011;42:1826-1833.)

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Elevated circulating levels of beta 2-microglobulin in patients with idiopathic dilated cardiomyopathy

Cited by 16 publications

References 11 publications

Neopterin and Beta-2 Microglobulin Relations to Immunity and Inflammatory Status in Nonischemic Dilated Cardiomyopathy Patients

Neopterin and Beta-2 Microglobulin Relations to Immunity and Inflammatory Status in Nonischemic Dilated Cardiomyopathy Patients

Association Between Serum β₂‐Microglobulin Levels and Prevalent and Incident Physical Frailty in Community‐Dwelling Older Women

Beta 2 Microglobulin and the Risk for Cardiovascular Events in Patients With Asymptomatic Carotid Atherosclerosis

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Elevated circulating levels of beta 2-microglobulin in patients with idiopathic dilated cardiomyopathy

Cited by 16 publications

References 11 publications

Neopterin and Beta-2 Microglobulin Relations to Immunity and Inflammatory Status in Nonischemic Dilated Cardiomyopathy Patients

Neopterin and Beta-2 Microglobulin Relations to Immunity and Inflammatory Status in Nonischemic Dilated Cardiomyopathy Patients

Association Between Serum β2‐Microglobulin Levels and Prevalent and Incident Physical Frailty in Community‐Dwelling Older Women

Beta 2 Microglobulin and the Risk for Cardiovascular Events in Patients With Asymptomatic Carotid Atherosclerosis

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Association Between Serum β₂‐Microglobulin Levels and Prevalent and Incident Physical Frailty in Community‐Dwelling Older Women