2020
DOI: 10.1016/j.clinthera.2020.05.001
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Elevated Circulating Th2 Cells in Women With Asthma and Psychological Morbidity: A New Asthma Endotype?

Abstract: Purpose: Psychological stress shifts the immune system toward the production of T-helper (Th)-2emediated cytokines and eosinophilia, increases the risks for both asthma and depression, and can precipitate asthma exacerbations. Th2mediated inflammation is a characteristic of allergic asthma. We have shown that the levels of CD4 + Th2 cells in the peripheral blood of patients with asthma are associated with severity and/or control of the disease. To improve our understanding of the interactions between stress an… Show more

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