Elevated cystatin C: is it a reflection for kidney or liver impairment in hepatic children?

Abstract

Aim of the studyTo assess if elevated serum cystatin C (Cyst-C) is an indicator for renal or hepatic dysfunction in presence of liver fibrosis.Material and methodsData of 50 children with chronic liver diseases (CLDs), out of which 25 were without renal impairment, and 25 with renal impairment were analyzed. Twenty healthy children served as a healthy control group. Routine investigations, creatinine clearance, hepatitis viral markers, abdominal ultrasonography, and liver biopsy were performed for patients with CLDs. Measurement of serum Cyst-C concentration by particle induced immunonephelometry were completed for both patients and control group.ResultsResults showed that serum Cyst-C is not correlated with the degree of hepatic impairment (p > 0.05). Cyst-C levels were significantly higher in patients with renal impairment (3.66 ± 0.85) than those without (0.71 ± 0.12), and healthy control group (0.63 ± 0.85). Cystatin-C showed significant elevation in patients with severe fibrosis with renal impairment (3.66 ± 0.85) than those without (0.76 ± 0.04) (p < 0.0001). Cyst-C at cutoff levels of 1.65 mg/l showed 100% accuracy in discrimination between those with and those without renal impairment. Cyst-C > 2.34 mg/l predicting GFR < 40 ml/min with accuracy of 90%. Cyst-C > 2.73 mg/l predicting GFR < 20 ml/min with accuracy of 81.5%.ConclusionsSerum Cyst-C is a promising marker to estimate renal impairment in children with CLDs. Further studies are needed to estimate the accuracy of serum Cyst-C for early detection of renal impairment and close monitoring of the hepatic children.

Serum Cystatin C Reference Interval and Derived Estimated Glomerular Filtration Rate Values in Healthy Adult Zimbabwean Blood Donors

“…Cystatin C, a serine protease plasma protein has been postulated to be a better marker for renal function than the commonly used serum creatinine [7]. Serum cystatin C is filtered freely at the glomerulus, reabsorbed in the proximal tubular cells and catabolised there [6,[8][9][10][11] and not secreted by renal tubules and is presumed to be not affected by sex, race, muscle mass or age [9][10]. .…”