Elevated cytokine levels in peritoneal fluid from burned patients with intra-abdominal hypertension and abdominal compartment syndrome

Kowal-Vern, Areta; Ortegel, John W.; Bourdon, Paul S.; Chakrin, Alan; Latenser, B.A.; Kimball, Douglas; Casey, Larry C.

doi:10.1016/j.burns.2005.12.010

Cited by 26 publications

(14 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased concentrations of pro-inflammatory cytokines have been demonstrated in burn patients with intra-abdominal hypertension/ACS, with increasing concentrations correlating with poorer outcome. (1) Increased levels of pro-inflammatory cytokines (TNF-α and IL-6) were associated with death in an animal model of peritonitis. (18) Although the concentration of IL-6 and TNF-α were small (ng) in our model, other investigators have demonstrated alterations in neutrophil biology at similar concentrations.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A novel mechanism for neutrophil priming in trauma: Potential role of peritoneal fluid

Shah¹,

Jiménez²,

Walker³

et al. 2010

Surgery

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…demonstrated peritoneal fluid in burned patients undergoing resuscitation contains increased levels of pro-inflammatory cytokines. (1) Sagara et. al.…”

Section: Introductionmentioning

confidence: 99%

A novel mechanism for neutrophil priming in trauma: Potential role of peritoneal fluid

Shah¹,

Jiménez²,

Walker³

et al. 2010

Surgery

View full text Add to dashboard Cite

show abstract

“…Serum concentrations of interleukin-6 and tumor necrosis factor-α have been found to be elevated in the early stages of burn injury [9]. KowalVern et al [11] reported a significant increase in plasma interleukin-6, tumor necrosis factor-α, and other inflammatory cytokines in burn patients with and without inhalation injury. Furthermore, Stengle et al [12] used a mouse model of 15% TBSA scald burn to demonstrate a significant elevation of pulmonary neutrophil infiltration within 6 hours of thermal injury and at 1 week postburn.…”

Section: Discussionmentioning

confidence: 98%

Respiratory failure after pediatric scald injury

Rocourt

Hall

Kenney

et al. 2011

Journal of Pediatric Surgery

View full text Add to dashboard Cite

“…Under these circumstances, inflammatory fluid is retained in the gut wall, intestinal villi secrete fluid into the gut lumen, and the luminal fluid does not rapidly regress from the gastrointestinal tract, contributing to IAH and even ACS [14,21]. Animal and human studies show that circulation of lymph containing a high concentration of cytokines can cause severe liver, kidney and lung injury and the development of MODS and is therefore associated with poor outcomes [16,18,20-22]. In animal models, abdominal NPT was shown to prevent the development of lung injury and was associated with decreases in leukocytes migrated to the kidney and liver [16,18].…”

Section: Discussionmentioning

confidence: 99%

Abdominal negative-pressure therapy: a new method in countering abdominal compartment and peritonitis - prospective study and critical review of literature

Plaudis

Rudzāts

Melberga

et al. 2012

Annals of Intensive Care

View full text Add to dashboard Cite

BackgroundApplication of abdominal negative-pressure therapy (NPT) is lifesaving when conservative measures fail to reduce sustained increase of the intra-abdominal pressure and it is impossible to achieve source control in a single operation due to severe peritonitis. The aim of this study is to share the initial experience with abdominal NPT in Latvia and provide a review of the relevant literature.MethodsIn total, 22 patients were included. All patients were treated with KCI® ABThera™ NPT systems. Acute Physiology and Chronic Health Evaluation II (APACHE II) score on admission, daily sequential organ failure assessment score and Mannheim peritonitis index (MPI) were calculated for severity definition. The frequency of NPT system changes, daily amount of aspirated fluid effluent and the time of abdominal closure were assessed. The overall hospital and ICU stay, as well as the outcomes and the complication rate, were analysed.ResultsA complicated intra-abdominal infection was treated in 18 patients. Abdominal compartment syndrome due to severe acute pancreatitis (SAP), secondary ileus and damage control in polytrauma were indications for NPT in four patients. The median age of the patients was 59 years (range, 28 to 81), median APACHE II score was 15 points (range, 9 to 32) and median MPI was 28 points (range, 21 to 40), indicating a prognostic mortality risk of 60%. Sepsis developed in all patients, and in 20 of them, it was severe. NPT systems were changed on a median of every 4 days, and abdominal closure was feasible on the seventh postoperative day without needing a repeated laparotomy. Two NPT systems were removed due to bleeding from the retroperitoneal space in patients with SAP. Intestinal fistulae developed in three patients that were successfully treated conservatively. Incisional hernia occurred in three patients. The overall ICU and hospital stay were 14 (range, 5 to 56) and 25 days (range, 10 to 87), respectively. Only one patient died, contributing to the overall mortality of 4.5%.ConclusionsApplication of abdominal NPT could be a very promising technique for the control of sustained intra-abdominal hypertension and management of severe sepsis due to purulent peritonitis. Further trials are justified for a detailed evaluation of abdominal NPT indications.

show abstract

Elevated cytokine levels in peritoneal fluid from burned patients with intra-abdominal hypertension and abdominal compartment syndrome

Cited by 26 publications

References 20 publications

A novel mechanism for neutrophil priming in trauma: Potential role of peritoneal fluid

A novel mechanism for neutrophil priming in trauma: Potential role of peritoneal fluid

Respiratory failure after pediatric scald injury

Abdominal negative-pressure therapy: a new method in countering abdominal compartment and peritonitis - prospective study and critical review of literature

Contact Info

Product

Resources

About