Elevated Depression Symptoms, Antidepressant Medicine Use, and Risk of Developing Diabetes During the Diabetes Prevention Program

Rubin, Richard R.; Ma, Yong; Marrero, David G.; Peyrot, Mark; Barrett‐Connor, Elizabeth; Kahn, Steven E.; Haffner, Steven M.; Price, David; Knowler, William C.

doi:10.2337/dc07-1827

Cited by 207 publications

(195 citation statements)

References 31 publications

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“…Concomitant to reduction in the frequency of BED, depression was reduced, which may be contributing to the improvement of QoL of the individuals under intensive intervention on lifestyle. At baseline, the high frequency of depression (47%) among our participants was similar to that found in other intervention studies [43]. Interestingly, depression symptoms decreased also in our traditional intervention, suggesting that a simple 30-min medical care may be effective to improve depression symptoms even not directed to this psychological disorder.…”

Section: Discussionsupporting

confidence: 88%

Benefits on quality of life concomitant to metabolic improvement in intervention program for prevention of diabetes mellitus

et al. 2011

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Objective To evaluate whether an interdisciplinary intervention program on lifestyle results in better quality of life (QoL) and lower frequencies of depression and binge eating disorder (BED) in individuals at risk for type 2 diabetes mellitus. Methods A total of 177 individuals (32.2% men, age 55.4 ± 12.5 years) at risk for diabetes were allocated to a 9-month traditional (TI) or intensive interdisciplinary intervention (II) on dietary habits and physical activity including psychoeducative groups. They were submitted to questionnaires and clinical and laboratory examinations. Predictors of non-adherence were analyzed by logistic regression. Results Only individuals submitted to II had blood pressure and plasma glucose levels reduced. Frequencies of depression reduced in both interventions but of BED only in II (28.0-4.0%, P \ 0.001). Increments in the scores of SF-36 domains (physical functioning: 11.1 ± 14.0 vs. 5.3 ± 13.0, role-emotional: 20.4 ± 40.2 vs. 6.2 ± 43.8, P = 0.05) were greater in the II than in TI, respectively. Changes in SF-36 correlated with decreases in anthropometry, blood pressure and glucose levels, depression and BED scores. Male gender was independently associated with non-adherence to the II. Conclusions In addition to metabolic benefits, an interdisciplinary approach may induce desirable extrametabolic effects, favoring the control of psychiatric disorders and improving the QoL of individuals at risk for diabetes.

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Section: Discussionsupporting

confidence: 88%

Benefits on quality of life concomitant to metabolic improvement in intervention program for prevention of diabetes mellitus

et al. 2011

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“…An association between depression and diabetes has been well recognized as the prevalence of depression is doubled in type 2 diabetics compared with the general population (1)(2)(3). However, treatment with currently available antidepressant drugs can increase the risk of developing type 2 diabetes among those at high risk for the disease (4)(5)(6). Thus, characterization of the biological factors for comorbidity of depression and diabetes and identification of innovative therapeutic targets for the treatment of depression, especially for those with comorbid diabetes, are urgently needed.…”

mentioning

confidence: 99%

Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity

Liu¹,

Guo²,

Zhang³

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

154

162

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Depression is a debilitating mental illness and is often comorbid with metabolic disorders such as type 2 diabetes. Adiponectin is an adipocyte-derived hormone with antidiabetic and insulin-sensitizing properties. Here we show that adiponectin levels in plasma are reduced in a chronic social-defeat stress model of depression, which correlates with decreased social interaction time. A reduction in adiponectin levels caused by haploinsufficiency results in increased susceptibility to social aversion, "anhedonia," and learned helplessness and causes impaired glucocorticoid-mediated negative feedback on the hypothalamic-pituitary-adrenal (HPA) axis. Intracerebroventricular (i.c.v.) injection of an adiponectin neutralizing antibody precipitates stress-induced depressive-like behavior. Conversely, i.c.v. administration of exogenous adiponectin produces antidepressantlike behavioral effects in normal-weight mice and in diet-induced obese diabetic mice. Taken together, these results suggest a critical role of adiponectin in depressive-like behaviors and point to a potential innovative therapeutic approach for depressive disorders.

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“…A significância manteve-se após controle dos fatores de confusão. Já no grupo MET não houve associação significativa 10 .…”

Section: Depressão Como Fator De Risco Para O Diabetesunclassified

Depressão e diabetes mellitus

Fráguas

Soares

Bronstein³

2009

Rev. psiquiatr. clín.

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ResumoO diabetes mellitus possui elevada prevalência, acometendo cerca de 7% da população brasileira. Em torno de 20% a 30% dos pacientes com diabetes apresentam depressão. A depressão pode atuar como um fator de risco para o desenvolvimento do diabetes, piorar seus sintomas e interferir com o autocuidado dos pacientes. Quando não tratada adequadamente, a depressão nesses pacientes tende a evoluir com elevada taxa de recorrência. Entre os tratamentos disponíveis, encontramos na literatura um benefício da psicoterapia, cognitiva ou cognitivo-comportamental, para melhora dos sintomas depressivos, mas sem evidência de um benefício no controle glicêmico. Os antidepressivos tricíclicos, em especial os com maior ação noradrenérgica, e os inibidores da monoaminoxidase (IMAOs) tendem a aumentar os níveis glicêmicos. A bupropiona não interfere na glicemia e há evidências de que os inibidores seletivos de recaptura de serotonina (ISRS) melhoram os níveis glicêmicos e podem reduzir a taxa de recaídas, mostrando-se boas opções de tratamento farmacológico. A eletroconvulsoterapia também é uma estratégia interessante para esses pacientes, recomendando-se, no entanto, monitorização da glicemia. Não foram encontrados estudos significativos sobre os demais antidepressivos disponíveis para comercialização. Fráguas R, et al. / Rev Psiq Clín. 2009;36(3):93-9Palavras-chave: Diabetes mellitus, depressão, tratamento, antidepressivo, prevalência, prognóstico. AbstractDiabetes mellitus has an estimated prevalence of 7% among Brazilian population. Around 20% to 30% of these patients have a depressive disorder. Depression can work as risk factor to the development of diabetes, can worse its symptoms and interfere with self-care. When not adequately treated, depressive disorder in these patients tends to have high rates of recurrence. Among the available treatments literature shows a benefit of psychotherapy, mainly cognitive or cognitive-behavioral, in ameliorating depressive symptoms, but without impact on glycaemic control. Tryciclic antidepressants, especially those with more noradrenergic profile, and monoamino oxidase inhibitors are associated with worsening of glycaemic control. Bupropion shows no action on glucose blood levels and there are evidences that serotonin selective reuptake inhibitors may improve the glycaemic levels and reduce the recurrence, being good choices to treat these patients. Electroconvulsive therapy is an interesting treatment to these patients, but monitoring of blood glucose is recommended. We did not find data about other antidepressants. R, et al. / Rev Psiq Clín. 2009;36(3):93-9 Fráguas

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Elevated Depression Symptoms, Antidepressant Medicine Use, and Risk of Developing Diabetes During the Diabetes Prevention Program

Cited by 207 publications

References 31 publications

Benefits on quality of life concomitant to metabolic improvement in intervention program for prevention of diabetes mellitus

Benefits on quality of life concomitant to metabolic improvement in intervention program for prevention of diabetes mellitus

Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity

Depressão e diabetes mellitus

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