Elevated expression of CCL5/RANTES in adult T‐cell leukemia cells: Possible transactivation of the <i>CCL5</i> gene by human T‐cell leukemia virus type I tax

Mori, Nozomu; Krensky, Alan M.; Ohshima, Koichi; Tomita, Masaru; Matsuda, Takehiro; Ohta, Takao; Yamada, Yasuaki; Tomonaga, Masao; Ikeda, Shu‐ichi; Yamamoto, Naoki

doi:10.1002/ijc.20266

Cited by 41 publications

(30 citation statements)

References 60 publications

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“…Previously, it has been reported that serum levels of MCP-1 are diminished in infected patients (93). However, enhanced levels of RANTES production and secretion have been documented in adult T-cell leukemia cell lines and PBMCs collected from HAM/TSP patients (94,95). Although it appears that exosomes do not contribute to the increased abundance of RANTES during HTLV-1 infection, it is possible that HTLV-1 infection or Tax expression could influence the production and secretion of other proinflammatory cytokines, including IL-6, via exosomes.…”

Section: C81 Mt2 and Ed(ϫ) Cell Lines Contain Inflammatorymentioning

confidence: 99%

Human T-lymphotropic Virus Type 1-infected Cells Secrete Exosomes That Contain Tax Protein

Jaworski

Narayanan

Duyne

et al. 2014

Journal of Biological Chemistry

149

180

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Background: Extracellular exosomes contain various functional elements. Results: Exosomal Tax protein causes phenotypic changes in uninfected cells. Conclusion: Exosomes may play critical roles in extracellular delivery of oncogenic material derived from HTLV-1-infected cells. Significance: Exosomal delivery of Tax and other putative oncogenic components produced during HTLV-1 infection potentially contributes to pathogenesis of adult T-cell leukemia, myelopathy, or tropical spastic paraparesis.

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Section: C81 Mt2 and Ed(ϫ) Cell Lines Contain Inflammatorymentioning

confidence: 99%

Human T-lymphotropic Virus Type 1-infected Cells Secrete Exosomes That Contain Tax Protein

Jaworski

Narayanan

Duyne

et al. 2014

Journal of Biological Chemistry

149

180

View full text Add to dashboard Cite

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“…A number of other cancer types have been shown to express CCL5, [70][71][72][73][74] induce inflammatory cell migration into the tumor site 71,73,74 and enhance tumor growth. 70 There is evidence that inflammatory chemokines including CCL5 expressed by prostate cells may act directly on the growth and survival of hormone-driven prostate cancer cells.…”

Section: Ccl5 and Other Cancersmentioning

confidence: 99%

CCL5 as a potential immunotherapeutic target in triple-negative breast cancer

Zhang

Kim

et al. 2013

Cell Mol Immunol

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Breast cancer (BC) is a leading cause of mortality among women in the world. To date, a number of molecules have been established as disease status indicators and therapeutic targets. The best known among them are estrogen receptor-a (ER-a), progesterone receptor (PR) and HER-2/neu. About 15%-20% BC patients do not respond effectively to therapies targeting these classes of tumor-promoting factors. Thus, additional targets are strongly and urgently sought after in therapy for human BCs negative for ER, PR and HER-2, the so-called triple-negative BC (TNBC). Recent clinical work has revealed that CC chemokine ligand 5 (CCL5) is strongly associated with the progression of BC, particularly TNBC. How CCL5 contributes to the development of TNBC is not well understood. Experimental animal studies have begun to address the mechanistic issue. In this article, we will review the clinical and laboratory work in this area that has led to our own hypothesis that targeting CCL5 in TNBCs will have favorable therapeutic outcomes with minimal adverse impact on the general physiology.

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“…13 In addition, a recent study demonstrated that the CXCR4 signal pathway may play a role in the metastasis of breast cancer cells by inducing chemotactic and invasive responses. 14 Human ATL cells have been shown to produce several chemokines, including macrophage inflammatory protein 1␣ (MIP-1␣), 3 MIP-3␣, 4 MIP-1␤, 5 I-309, 6 thymus-and activation-regulated chemokine (TARC), and macrophage-derived chemokine (MDC), 7 and express the chemokine receptors CCR4, 15 CCR5, 16 CCR7, 17 and CCR9, 18 and it has been suggested that some of these may be involved in ATL cell migration and infiltration.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of the SDF-1α–CXCR4 axis by the CXCR4 antagonist AMD3100 suppresses the migration of cultured cells from ATL patients and murine lymphoblastoid cells from HTLV-I Tax transgenic mice

Kawaguchi

Orba

Kimura

et al. 2009

Blood

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Elevated expression of CCL5/RANTES in adult T‐cell leukemia cells: Possible transactivation of the CCL5 gene by human T‐cell leukemia virus type I tax

Abstract: HTLV-I is

Cited by 41 publications

References 60 publications

Human T-lymphotropic Virus Type 1-infected Cells Secrete Exosomes That Contain Tax Protein

Human T-lymphotropic Virus Type 1-infected Cells Secrete Exosomes That Contain Tax Protein

CCL5 as a potential immunotherapeutic target in triple-negative breast cancer

Inhibition of the SDF-1α–CXCR4 axis by the CXCR4 antagonist AMD3100 suppresses the migration of cultured cells from ATL patients and murine lymphoblastoid cells from HTLV-I Tax transgenic mice

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