Elevated expression of FGF7 protein is common in human gastric diseases

Shaoul, Ron; Eliahu, Liat; Sher, Ifat; Hamlet, Yaheli; Miselevich, Ines; Goldshmidt, Orit; Ron, Dina

doi:10.1016/j.bbrc.2006.08.198

Cited by 28 publications

(20 citation statements)

References 33 publications

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“…Increased FGF7 protein levels were reported in gastric cancer 25 . Numerous growth hormones, such as insulin-like growth factor, epidermal growth factor, fibroblast growth factor, and vascular endothelial growth factor, influence the growth of leiomyoma 26 .…”

Section: Discussionmentioning

confidence: 99%

Gene expression analysis of uterine smooth muscle cells exposed to bisphenol A

Kang

Song

Cho

2014

Toxicol. Environ. Health Sci.

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To evaluate the effect of bisphenol A (BPA) on gene expression changes in uterine myometrium, uterine smooth muscle cells were incubated with 2.28 ng/mL BPA for 48 h. Total RNA was extracted and quantified spectrophotometrically. Gene expression changes were analyzed using oligonucleotide microarray hybridization comparing the treated and control groups (1.5-fold change, p⁄ ⁄0.05). Data indicated that 560 genes were upregulated and 231 were downregulated in response to BPA exposure. The biological processes positively associated with gene upregulation included the regulation of cell differentiation, cellular metabolic processes, cell proliferation and smooth muscle contraction. In contrast, genes involved in mitosis, lipid metabolism, regulation of muscle cell differentiation and cell adhesion were significantly downregulated. In the KEGG pathway analysis, MAPK signaling pathway, insulin signaling pathway and extracellular matrix (ECM)-mediated interactions were positively associated with gene upregulation. Results Gene Expression Profiles Induced by BPA in Uterine Smooth Muscle CellGene expression changes were analyzed by comparing the treated and control groups using statistical criteria (1.5-fold change, p⁄0.05). Three independent samples were analyzed. Results indicated that 560 genes were upregulated in response to BPA exposure and 231 were downregulated.The 560 upregulated and 231 downregulated genes were classified according to the GO terms of biological processes and KEGG pathway analysis, to investigate the molecular mechanisms related to BPA exposure. EASE analysis (http://david.abcc.ncifcrf.gov/) was also performed. The key biological processes that were significantly affected (Fisher's exact test, p⁄

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Section: Discussionmentioning

confidence: 99%

Gene expression analysis of uterine smooth muscle cells exposed to bisphenol A

Kang

Song

Cho

2014

Toxicol. Environ. Health Sci.

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“…FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including tumor growth and invasion. FGF7 is a potent epithelial cellspecific growth factor, and is involved in tumorigenesis through stimulating proliferation and invasion (Ropiquet et al, 1999;Shaoul et al, 2006). These findings raised the possibility that IRX1 overexpression downregulated expression of BDKRB2, FGF7 and HIST2H2BE, consequently inhibiting angiogenesis, cell proliferation and invasion in gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

Homeobox gene IRX1 is a tumor suppressor gene in gastric carcinoma

et al. 2010

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The IRX1 tumor suppressor gene is located on 5p15.33, a cancer susceptibility locus. Loss of heterozygosity of 5p15.33 in gastric cancer was identified in our previous work. In this study, we analyzed the molecular features and function of IRX1. We found that IRX1 expression was lost or reduced in gastric cancer. However, no mutations were identified in IRX1-encoding regions. IRX1 transcription was suppressed by hypermethylation, and the expression of IRX1 mRNA was partially restored in gastric cancer cells after 5-Aza-dC treatment. Restoring IRX1 expression in SGC-7901 and NCI-N87 gastric cancer cells inhibited growth, invasion and tumorigenesis in vitro and in vivo. We identified a number of target genes by global microarray analysis after IRX1 transfection combined with real-time PCR and chromatin immunoprecipitation assay. BDKRB2, an angiogenesis-related gene, HIST2H2BE and FGF7, cell proliferation and invasionrelated genes, were identified as direct IRX1 target genes. The hypermethylation of IRX1 was not only detected in primary gastric cancer tissues but also in the peripheral blood of gastric cancer patients, suggesting IRX1 could potentially serve as a biomarker for gastric cancer.

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“…Among the various growth factors which are produced from fibroblasts, one of growth-stimulating factors from gastric fibroblasts that affected scirrhous gastric cancer cells is fibroblast growth factor-7 (FGF-7) [9,10]. FGF-7, a member of the FGF family [11] also known as keratinocyte growth factor (KGF), originally was isolated from human embryonic lung fibroblasts and is produced by mesenchymal cells in various tissues.…”

Section: Fgf-7 Produced From Gastric Fibroblasts Stimulates Proliferamentioning

confidence: 99%

“…FGF-7, a member of the FGF family [11] also known as keratinocyte growth factor (KGF), originally was isolated from human embryonic lung fibroblasts and is produced by mesenchymal cells in various tissues. FGF-7 exerts its effect in a paracrine manner limited to epithelial cells [10], while other FGF family members also stimulate the growth of cultured endothelial cells and fibroblasts. Four members of the FGF receptor (FGFR) family, FGFR-1 (Flg), FGFR-2 (K-sam), FGFR-3, and FGFR-4, have been identified [12].…”

Section: Fgf-7 Produced From Gastric Fibroblasts Stimulates Proliferamentioning

confidence: 99%

Cancer–Stromal Interactions in Scirrhous Gastric Carcinoma

Yashiro

Hirakawa

2010

Cancer Microenvironment

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Fibroblasts play an important role in the progression, growth and spread of gastric cancers. Cancer-stroma interactions have been especially evident in the scirrhous type of gastric carcinoma. Fibroblasts are associated with the cancer progression at the primary and metastatic site. The proliferative and invasive ability of scirrhous gastric cancer cells are closely associated with the growth factors produced by organ-specific fibroblasts. Fibroblasts are therefore a key determinant in the malignant progression of gastric cancer and represent an important target for cancer therapies.

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Elevated expression of FGF7 protein is common in human gastric diseases

Cited by 28 publications

References 33 publications

Gene expression analysis of uterine smooth muscle cells exposed to bisphenol A

Gene expression analysis of uterine smooth muscle cells exposed to bisphenol A

Homeobox gene IRX1 is a tumor suppressor gene in gastric carcinoma

Cancer–Stromal Interactions in Scirrhous Gastric Carcinoma

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