Elevated FABP1 serum levels are associated with poorer survival in acetaminophen‐induced acute liver failure

Karvellas, Constantine J.; Speiser, Jaime L.; Tremblay, Mélanie; Lee, William M.; Rose, Christopher F.

doi:10.1002/hep.28945

Cited by 58 publications

(46 citation statements)

References 42 publications

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“…In addition, FABP1 is a promising indicator of ongoing liver injury as its levels were found to increase before those of ALT, and decreased after treatment stopped, while ALT levels remained unchanged (Mikus et al, 2017). Further, APAPinduced ALF survivors had significantly lower serum FABP1 levels than did non-survivors in early stage and late stage, indicating the elevated FABP1 levels in patients with APAPinduced ALF were associated with a poor outcome (Karvellas et al, 2017). Furthermore, a higher FABP1 concentration (> 350 ng/ml) was associated with increased mortality (Karvellas et al, 2017).…”

Section: Fatty Acid Binding Protein 1 (Fabp1)mentioning

confidence: 99%

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Molecular Biomarkers in Drug-Induced Liver Injury: Challenges and Future Perspectives

Jiang

et al. 2020

Front. Pharmacol.

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Drug-induced liver injury (DILI) is one among the common adverse drug reactions and the leading causes of drug development attritions, black box warnings, and post-marketing withdrawals. Despite having relatively low clinical incidence, its potentially severe adverse events should be considered in the individual patients due to the high risk of acute liver failure. Although traditional liver parameters have been applied to the diagnosis of DILI, the lack of specific and sensitive biomarkers poses a major limitation, and thus accurate prediction of the subsequent clinical course remains a significant challenge. These drawbacks prompt the investigation and discovery of more effective biomarkers, which could lead to early detection of DILI, and improve its diagnosis and prognosis. Novel promising biomarkers include glutamate dehydrogenase, keratin 18, sorbitol dehydrogenase, glutathione S-transferase, bile acids, cytochrome P450, osteopontin, high mobility group box-1 protein, fatty acid binding protein 1, cadherin 5, miR-122, genetic testing, and omics technologies, among others. Furthermore, several clinical scoring systems have gradually emerged for the diagnosis of DILI including the Roussel Uclaf Causality Assessment Method (RUCAM), Clinical Diagnostic Scale (CDS), and Digestive Disease Week Japan (DDW-J) systems. However, currently their predictive value is limited with certain inherent deficiencies. Thus, perhaps the greatest benefit would be achieved by simultaneously combining the scoring systems and those biomarkers. Herein, we summarized the recent research progress on molecular biomarkers for DILI to improved approaches for its diagnosis and clinical management.

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Section: Fatty Acid Binding Protein 1 (Fabp1)mentioning

confidence: 99%

“…• FABP1 has superior characteristics regarding tissue distribution and kinetics compared to ALT. Wu et al, 2016b;Karvellas et al, 2017;Mikus et al, 2017;Wu et al, 2017 CDH5…”

Section: High Mobility Group Box-1 Protein (Hmgb1)mentioning

confidence: 99%

Molecular Biomarkers in Drug-Induced Liver Injury: Challenges and Future Perspectives

Jiang

et al. 2020

Front. Pharmacol.

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“…We thank Fan et al for their recent interest in our publication on liver-type fatty acid binding protein (FABP1) in acetaminophen-induced acute liver failure (APAP-ALF). (1) In this study, we demonstrated that FABP1 may have good potential to discriminate survivors from nonsurvivors and improve models currently used in clinical practice in APAP-ALF.…”

Section: Replymentioning

confidence: 71%

“…In a recent issue of HEPATOLOGY, Karvellas et al (1) reported a study in which they investigated whether early (day 1) or late (day 3-5) elevations in levels of serum liver-type fatty acid binding protein (FABP1) are associated with 21-day mortality in the absence of liver transplantation. The authors concluded that in patients with acetaminophen (APAP)-induced acute liver failure (ALF), FABP1 may have good potential to discriminate survivors from nonsurvivors and may improve models currently used in clinical practice.…”

Section: To the Editormentioning

confidence: 99%

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et al. 2017

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Selective Twin NIR‐IIb Ratiometric Luminescence Nanoprobes Enable the Accurate Visualization of MPO‐Mediated Oxidative Stress in Acute Liver Injury

Liu,

Li,

Shen

et al. 2024

Adv Funct Materials

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Oxidative stress, orchestrated by myeloperoxidase (MPO), plays crucial roles in the progression of many diseases. Nonetheless, the role of MPO‐mediated oxidative stress in distinct factor‐induced acute liver injuries (ALI) is still up for dispute, mainly due to the lack of probes for in vivo monitoring of MPO releases. Here, a highly selective MPO probe (CSQ) based on the epoxidation biochemical reaction within the MPO‐H2O2‐Cl− system is screened to construct dual near infrared‐IIb (NIR‐IIb) ratiometric (F1550Em, 808Ex/F1550Em, 980Ex) luminescence nanoprobes by integrating CSQ onto down conversion nanoparticles (DCNPs) with and without liver‐targeting moiety (twin NIR‐IIb nanoprobes). Liver‐targeting probes are employed to monitor MPO release, whereas non‐liver‐targeting probes are utilized to assess MPO activity across all cell types. Using twin NIR‐IIb nanoprobes, the MPO‐mediated oxidative stress progressively increased are observed in carbon tetrachloride (CCl4)‐induced ALI over 12 h. In contrast, the MPO‐mediated oxidative stress in acetaminophen (APAP)‐induced ALI initially increased, peaked within 3 h, and then rapidly weakened to normal levels within 12 h. Importantly, the differential release of MPO from neutrophils/Kupfer cells to extracellular fluids in the two types of ALI is revealed. This work reveals significant differences in MPO distribution and the role of MPO‐mediated oxidative stress in CCl4 and APAP‐induced ALI.

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Elevated FABP1 serum levels are associated with poorer survival in acetaminophen‐induced acute liver failure

Cited by 58 publications

References 42 publications

Molecular Biomarkers in Drug-Induced Liver Injury: Challenges and Future Perspectives

Molecular Biomarkers in Drug-Induced Liver Injury: Challenges and Future Perspectives

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Selective Twin NIR‐IIb Ratiometric Luminescence Nanoprobes Enable the Accurate Visualization of MPO‐Mediated Oxidative Stress in Acute Liver Injury

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