Elevated factor VIII in a patient with acute coronary syndrome

Costa, Cátia; Alves, Miguel; Durão, David; Leal, Margarida; Monteiro, Isabel

doi:10.1016/j.repce.2013.09.012

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…The role of vWF as a predictor of the development of thrombotic complications in PAD patients, including myocardial infarction, may be explained by its biological function; it functions in the adhesion of platelets to the endothelium and protection of factor VIII from proteolysis by protein C, which determine both platelet and fibrin components of intra-arterial thrombosis. In relation, Costa et al [18] reported an association between factor VIII and acute myocardial infarction.…”

Section: Discussionmentioning

confidence: 97%

Coagulation Factor Activity and Hemostatic Markers of Endothelial Dysfunction in Patients with Peripheral Arterial Disease

Каlinin

Suchkov

Mzhavanadze

et al. 2021

Vasc Specialist Int

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Purpose We aimed to evaluate the impact of intrinsic coagulation factors and hemostatic markers of endothelial dysfunction on complications in patients with atherosclerotic peripheral arterial disease (PAD). Methods Materials and This prospective study enrolled 120 PAD patients at Fontaine stages 2b to 3 who underwent open surgical, endovascular, or conservative treatment. Coagulation factors (FVIII, FIX, and FXI) and endothelial hemostatic markers, including von Willebrand factor (vWF) activity and level, soluble endothelial protein C receptor, and plasminogen activator inhibitor-1 (PAI-1) levels, were assessed. Results At 3 months after open bypass grafting, activity of FVIII significantly increased from a median of 175% to 233% (P<0.001). At 3 months after endovascular treatment, the activities of FVIII, FIX, and FXI significantly increased from medians of 157%, 180%, and 156% to 184%, 218%, and 181%, respectively (P<0.05). Six patients with increased FVIII activity developed bypass graft thrombosis. Four patients in the endovascular group and three patients in the conservative treatment group with increased activity of vWF developed myocardial infarction (P=0.049). The subjects who developed restenosis had increased vWF activity (P=0.023) and decreased nitric oxide metabolite levels (P=0.003). Three subjects who received conservative treatment and developed PAD progression at 12 months had increased PAI-1 activity (P=0.028). Conclusion Patients with advanced PAD had a hypercoagulable status, and performance of open or endovascular revascularization was associated with further hypercoagulability. Increased activity of coagulation factors and altered levels of hemostatic markers of endothelial dysfunction were associated with PAD complications such as graft thrombosis, myocardial infarction, disease progression, and restenosis.

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Section: Discussionmentioning

confidence: 97%

Coagulation Factor Activity and Hemostatic Markers of Endothelial Dysfunction in Patients with Peripheral Arterial Disease

Каlinin

Suchkov

Mzhavanadze

et al. 2021

Vasc Specialist Int

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“…Costa et al recently reported a case of a 36year-old man with a history of ST-elevation myocardial infarction at the age of 26 years, who was found to have elevated levels of factor VIII. 10 The case of a healthy 48-yearold woman who suffered cerebral venous thrombosis with no identifiable risk factors other than an elevated factor VIII level has also been reported. 11 Another study found that in patients who had suffered a stroke, those with elevated factor VIII levels were more likely to show evidence of a carotid or cerebral thrombus and presented with more disability when compared with those patients with normal levels of factor VIII.…”

Section: Discussionmentioning

confidence: 99%

Elevated Factor VIII Levels Associated with Acute Graft Occlusion and Arterial and Venous Thrombosis After Off Pump CABG

Kyaw

Manetta

2015

Int J Angiol

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Factor VIII is a common acute phase reactant and elevated levels confer an increased risk of thrombosis. Such thrombotic events have been documented in the literature, though to a limited extent. We present the case of a 54-year-old man presenting with a non?Q-wave myocardial infarction who was found to have triple vessel disease and subsequently underwent a 4-vessel coronary artery bypass grafting (CABG). Postoperatively, he was found to have multiple occluded vessels, deep vein thromboses, and a cerebrovascular accident (CVA). A hypercoagulability work-up revealed significantly elevated levels of factor VIII at 377% normal, which likely contributed to these thrombotic events. Further exploration is warranted to elucidate causal mechanisms of these thrombotic events, particularly of multiple graft occlusions, and to guide clinical decision making with regards to anticoagulation and stent management.

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Factor VIII: New mechanism of the coagulant regulation of FVIII and activated protein C/protein S

雅博¹

2014

Nihon Kessen Shiketsu Gakkaishi

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Elevated factor VIII in a patient with acute coronary syndrome

Cited by 3 publications

References 13 publications

Coagulation Factor Activity and Hemostatic Markers of Endothelial Dysfunction in Patients with Peripheral Arterial Disease

Coagulation Factor Activity and Hemostatic Markers of Endothelial Dysfunction in Patients with Peripheral Arterial Disease

Elevated Factor VIII Levels Associated with Acute Graft Occlusion and Arterial and Venous Thrombosis After Off Pump CABG

Factor VIII: New mechanism of the coagulant regulation of FVIII and activated protein C/protein S

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