Elevated Factor VIII Levels and the Risk of Thrombosis

Kamphuisen, Pieter Willem; Eikenboom, Jeroen; Bertina, Rogier M.

doi:10.1161/01.atv.21.5.731

Cited by 277 publications

(248 citation statements)

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“…The degree of atherogenesis among PWH has been shown to be similar to that in unaffected males [22,23]. In a recent review of the role of elevated FVIII levels and the risk of thrombosis, Kamphuisen et al [24] concluded that high levels of FVIII are indeed a risk factor for thrombosis, levels of FVIII 150% accounted for 16% of all venous thrombosis and levels of 123% explained 4% of arterial thrombosis. While the role that high levels of FVIII might play in thrombosis among persons with hemophilia cannot be defined at this point, such levels can potentially be achieved during factor concentrate infusions.…”

Section: Discussionmentioning

confidence: 99%

“…Von Willebrand factor levels may also play an important modifying role [26]. It is well known that individuals with blood group O have lower levels of von Willebrand factor than those with other blood types and, in patients with hemophilia A, a shorter half-life of infused FVIII has been observed in patients with type-O blood [24]. Future studies are needed to define the role of prothrombotic risk factors, particularly in mild hemophilia with IHD.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and risk factors for heart disease among males with hemophilia

2005

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence and risk factors for heart disease among males with hemophilia

2005

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“…The basis of high levels of FVIII is unclear: it is partly associated with ABO blood group (lower levels in type O) and APC resistance, but additional variation in FVIII levels has been shown to cluster in families too [22]. When a cut-off point for high levels of 150 IU/dl is used the prevalence of elevated FVIII:C is high: 11% of healthy control subjects and 25% of patients with a first episode of deep-vein thrombosis were found to have FVIII:C levels N150 IU/dl [23]. Factor VIII in plasma is bound to von Willebrand factor (VWF) and its levels are to a large degree determined by the levels of VWF, which on its turn are dependent on blood group [24,25].…”

Section: Introductionmentioning

confidence: 99%

Factor VIII levels and the risk of pre-eclampsia, HELLP syndrome, pregnancy related hypertension and severe intrauterine growth retardation

Witsenburg

Rosendaal

Middeldorp

et al. 2005

Thrombosis Research

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Objective: Recently, acquired as well as genetic prothrombotic factors are associated with thrombotic events. These factors have also been related to conditions of uteroplacental insufficiency such as pre-eclampsia, HELLP syndrome and severe intrauterine growth restriction (IUGR). The aim of this study was to determine whether elevated factor VIII levels are associated with uteroplacental insufficiency, in particular pre-eclampsia, HELLP syndrome or pregnancy-induced hypertension and intrauterine growth retardation. Methods: Plasma samples of 75 women with a history of pregnancy complicated by pre-eclampsia, HELLP syndrome, pregnancy induced hypertension or intrauterine growth restriction were tested for factor VIII:C (FVIII:C) levels at a minimum of 10 weeks post-partum. Laboratory results were compared to factor VIII:C levels found in a healthy control group of 272 women. Results: Mean factor VIII:C levels were similar at 123 IU/dl in both the patient group and the controls. In a logistic regression model, after adjusting for age and blood group, no effect of factor VIII:C levels on the risk of pregnancy complications was observed, with the exception of IUGR with (OR 2.9, CI 1.0-8.7) or without hypertension (OR 2.0, CI 0.7-6.4). Conclusion: If the elevated level of factor VIII would be the sole factor responsible for the increased risk observed, one would expect to find an effect of blood group on 0049-3848/$ -see front matter D

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“…Excess antihemophilic factor A or factor VIII is found in 11% of the population. These levels vary with age (increase of 6 IU / dL per decade), sex (women> men), blood group (AB> A = B> O) or ethnic origin (Black> White) (Kamphuisen et al, 2001;Koster et al, 1995). They also increase in some conditions such as inflammation, pregnancy, hyperthyroidism, hepatic or arterial disease.…”

Section: Thrombophilia:-mentioning

confidence: 99%