Elevated fecal M2‐pyruvate kinase in children with cystic fibrosis: A clue to the increased risk of intestinal malignancy in adulthood?

Abstract

Increased intestinal cell turnover is present in children with PI CF. The lack of relationship between fecal M2-PK and calprotectin suggests that contributing factor(s) other than inflammation may be present.

High ambient temperature and risk of intestinal obstruction in cystic fibrosis

“…This may be, in part, due to previous studies not subcategorising DIOS into complete and incomplete types. Furthermore, the other study to date using the consensus definition did not report their subjects according to gender . The reason(s) for this gender difference is unclear but may be related to greater levels of physical activity including vigorous exercise in men than in women, which in the presence of hot ambient temperatures may result in greater degrees of dehydration.…”

“…Furthermore, the other study to date using the consensus definition did not report their subjects according to gender. 8 The reason(s) for this gender difference is unclear but may be related to greater levels of physical activity including vigorous exercise in men than in women, 21 which in the presence of hot ambient temperatures may result in greater degrees of dehydration. Alternatively, poorer adherence to advice and treatment among men compared with women may be a contributing factor.…”

“…Intestinal obstruction in the newborn from meconium ileus (MI), which occurs in 15% of patients, is the earliest clinical manifestation of CF . Gastrointestinal complications are common and diverse and include distal intestinal obstruction syndrome (DIOS), constipation, intussusception, intestinal atresia, small bowel bacterial overgrowth, intestinal inflammation, malignancy and pancreatitis …”

“…1,2 Gastrointestinal complications are common and diverse and include distal intestinal obstruction syndrome (DIOS), constipation, intussusception, intestinal atresia, small bowel bacterial overgrowth, intestinal inflammation, malignancy and pancreatitis. [2][3][4][5][6][7][8] There are similarities and differences between DIOS and constipation in CF. Both conditions are associated with abnormally dehydrated and viscid mucofaecal material because of dysfunction of the CF transmembrane conductance regular (CFTR) protein in the intestinal mucosa.…”

Age-related levels of fecal M2-pyruvate kinase in children with cystic fibrosis and healthy children 0 to 10 years old

“…As a result, M2-PK can be raised in the setting of malignancy [15] and inflammatory states such as inflammatory bowel disease (IBD) [14]. A cross-sectional study previously reported significantly higher fecal M2-pyruvate kinase (M2-PK) levels in children with CF (aged 0 to 18 years) compared to healthy subjects [16]. However in this study there was no correlation between fecal M2-PK and calprotectin levels in the same CF cohort, suggesting other factor(s) may contribute to increased gut cell turnover apart from intestinal inflammation [16].…”